Articles tagged "Glomerular filtration rate (GFR)"

2015 American Transplant Congress
Transplantation of Neonatal En-Bloc Kidneys: Do They Grow and Are They Subject to Hyperfiltration Injury?
J. Woloszyn, C. Santhanakrishnan, C. Troppmann, A. DeMattos, B. Gallay, J. McVicar, J. Sageshima, R. Perez.
UC Davis Transplant Center, Sacramento, CA.
Importance:Neonatal Intensive Care Unit (NICU) kidney donation is rare but a potentially significant kidney source. Concerns with using these small kidneys include the risk for…
2015 American Transplant Congress
A 52-Week, Multicenter, Prospective, Observational, Non-Interventional, Open-Label Study to Assess the Effectiveness, Safety and Tolerability of Everolimus in Kidney Transplant Patients in Taiwan
S.-M. Wang,¹ P.-C. Lee,² J.-D. Lian,³ K.-H. Shu,⁴ S.-T. Wu,⁵ H.-C. Chen,⁶ C.-C. Huang,⁷ M.-S. Wu,⁸ Y.-C. Tian,⁹ Y.-J. Chiang,¹⁰ Y.-T. Chen,¹¹ H.-P. Wang.¹²
¹National Taiwan University Hospital, Taipei, Taiwan; ²National Cheng Kung University Hospital, Tainan, Taiwan; ³Chung Shan Medical University Hospital, Taichung, Taiwan; ⁴Taichung Veteran's General Hospital, Taichung, Taiwan; ⁵TriService General Hospital, Taipei, Taiwan; ⁶Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; ⁷China Medical University Hospital, Taichung, Taiwan; ⁸Taipei Medical University Hospital, Taipei, Taiwan; ⁹ChangGung Memorial Hospital–Taipei, Taipei, Taiwan; ¹⁰ChangGung Memorial Hospital–LinKou, Taoyuan, Taiwan; ¹¹ChangGung Memorial Hospital-Kaohsiung, Kaohsiung, Taiwan; ¹²E-Da Hospital, Kaohsiung, Taiwan.
The study aimed to assess the clinical safety and tolerability of everolimus (EVR) in Taiwan kidney transplant patients.This study enrolled 203 kidney transplant recipients, between…
2015 American Transplant Congress
Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease
S. Gonzalez,¹ J. Trotter,¹ H. Szerlip,² M. Levy,³ A. Chandrakantan,⁴ A. Yango,⁴ A. Rajagopal,⁴ Y. Barri,⁴ K. Rice,⁴ M. Saim,² L. Melton,⁴ M. Emmett,² G. Klintmalm,³ B. Fischbach.⁴
¹Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; ²Nephrology, Baylor University Medical Center, Dallas, TX; ³Transplant Surgery, Baylor Simmons Transplant Institute, Fort Worth, TX; ⁴Nephrology, Baylor Simmons Transplant Institute, Fort Worth, TX.
Background: Renal insufficiency is common in end-stage liver disease (ESLD) and is linked to survival in patients awaiting liver transplantation. Serum creatinine correlates poorly with…
2015 American Transplant Congress
Living Donor Characteristics Associated With Changes in Post-Donation GFR
E. Poggio,¹ D. Mandelbrot,⁴ P. Reese,⁵ D. Goldfarb,³ S. Flechner,³ J. Schold.²
¹Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH; ²Qualitative Health Sciences, Cleveland Clinic, Cleveland, OH; ³Urology, Cleveland Clinic, Cleveland, OH; ⁴Division of Medicine, University of Wisconsin, Madison, WI; ⁵Nephrology, University of Pennsylvania, Philadelphia, PA.
Living donor transplantation is the preferred modality for treatment of ESRD because it confers excellent outcomes for recipients and poses reasonable risks to most donors.…
2015 American Transplant Congress
1-Year Safety and Efficacy of Eculizumab in Adult aHUS Patients, With or Without a History of Renal Transplant
C. Legendre,¹ J. Kincaid,² C. Bedrosian,² C. Loirat.³
¹University Paris Descartes & Hôpital Necker, Paris, France; ²Alexion, Cheshire, CT; ³Assistance Publique–Hôpitaux Paris, Hôpital Robert-Debré, Paris, France.
Background: Atypical hemolytic-uremic syndrome (aHUS) is a life-threatening, chronic disease of complement-mediated TMA. In aHUS, renal transplantation is associated with post-transplant (TP) TMA and ∼50–70%…
2015 American Transplant Congress
Hypothermic Machine Perfusion Improves Kidney Viability through Amelioration of Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells
Z. Zhong,¹ Z. Liu,¹ Z. Fu,² Y. Zhang,² D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Hypothermic machine perfusion (MP) may improve outcome after transplantation from donors after cardiac death (DCD) kidneys, but protective mechanisms of MP remain largely unknown. To…
2015 American Transplant Congress
Acute Kidney Injury in the Early Post Kidney Transplant Period: Frequency, Etiology and Significance
B. Kiberd,¹ S. Cimen,¹ K. Tennankore.²
¹Surgery, Dalhousie University, Halifax, NS, Canada; ²Medicine, Dalhousie University, Halifax, NS, Canada.
Acute kidney injury (AKI) post kidney transplant has not been well described using current diagnostic criteria. The frequency and etiology of AKI in the first…
2015 American Transplant Congress
Age-Dependent Decline in Glomerular Filtration Rate: A US Population-Based Study
P. Udompap, N.-Y. Heo, A. Mannalithara, W. Kim.
Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA.
Background and aim: Reduced renal function is nearly a universal complication experienced by organ transplant recipients, in part related to nephrotoxicity of calcineurin inhibitors. With…
2015 American Transplant Congress
NK-Cell Subset Distribution, Renal Function and Biopsy Findings in Kidney Transplant Recipients With HLA Donor-Specific Antibodies
M. Crespo,¹ D. Redondo,¹ J. Gimeno,² J. Yelamos,³ A. Muntasell,³ A. Faura,¹ M. Pérez-Sáez,¹ M. López-Montañes,⁴ A. Torío,⁵ C. García,⁶ M. Mir,¹ J. Hernandez,⁶ M. López-Botet,^3,4 J. Pascual.¹
¹Nephrology Unit, Hospital del Mar, Barcelona, Spain; ²Servicio de Anatomía Patológica, Hospital del Mar, Barcelona, Spain; ³Servicio de Inmunología, Institut Mar d'Investigacions Mediques, Barcelona, Spain; ⁴Universitat Pompeu Fabra, Barcelona, Spain; ⁵Laboratori de Referencia de Catalunya, Barcelona, Spain; ⁶Immunology Department, Hospital de Alicante, Alicante, Spain.
Background: Detection of post-transplant donor-specific anti-HLA antibodies(DSA) constitutes a risk factor for kidney transplant (KT) loss. NK-cell antibody-dependent cell mediated cytotoxicity(ADCC) has been proposed to…
2015 American Transplant Congress
Longitudinal eGFR Modelling to Understand Rates of eGFR Decline in Renal Transplantation in the United Kingdom
R. Pruthi,¹ A. Casula,¹ R. Hilton,² R. Ravanan,³ P. Roderick,⁴ I. Macphee.⁵
¹UK Renal Registry, Bristol, United Kingdom; ²Guys Hospital, London, United Kingdom; ³Southmead Hospital, Bristol, United Kingdom; ⁴Southampton University, Southampton, United Kingdom; ⁵St Georges Hospital, London, United Kingdom.
Background: The rate of decline in eGFR (slope) has been independently associated with a higher risk of cardiovascular events and all cause mortality in kidney…