2019 American Transplant Congress
Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Neutrophils are key mediators of ischemia/reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Once activated, they release nuclear DNA web-like structures called neutrophil extracellular…2018 American Transplant Congress
HO-1 Regulates SIRT1– Autophagy Pathway in Liver Transplantation: From Mouse-to-Human
Liver ischemia-reperfusion injury (IRI) represents a major risk factor for early graft dysfunction and a key obstacle to expanding the donor pool in orthotopic liver…2017 American Transplant Congress
Liver Targeted Expression of a Single Allogeneic MHC I Molecule Promotes Tolerance to Pancreatic Islet Allograft by Inducing Specific CD8+ Regulatory T Cells in Mice.
A. Induction of donor-specific immune tolerance is a good alternative to chronic life-long immunosuppression for transplant patients. Donor major histocompatibility complex (MHC) molecules represent the…2017 American Transplant Congress
Human IL-10 Transfection of Porcine Lungs Significantly Increases IL-10 Levels in Vascular Perfusate During Human Blood Perfusion.
PurposePorcine organs are a potential source for clinical xenotransplantation. Pig lungs perfused with human blood exhibit inflammation and loss of vascular barrier function within hours.…2016 American Transplant Congress
Anti-Inflammatory Effects of AAV-Mediated TIMP-1 Gene Transfer in Hepatic Ischemia-Reperfusion Injury.
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase1 (TIMP-1) is the…2015 American Transplant Congress
Targeted Silencing of TLR Adaptor Genes Using Mannose Liposome to Prolong Cardiac Allograft Survival
Background: MyD88 and TRIF, the common adaptors of Toll-like receptors (TLRs) signaling, evoke dendritic cells (DCs)-mediated antigen-specific immune rejection. Abolish TLR-induced adaptive immune response in…2015 American Transplant Congress
AAV-Mediated TIMP-1 Gene Therapy Ameliorates Hepatic Ischemia/Reperfusion Injury
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…2015 American Transplant Congress
HO-1 Modified Macrophages Promote Autophagy by Activating Sirt1/TGF-β/Smad4 Signaling in Ischemia-Stressed Mouse Liver Transplants
Background: Although heme oxygenase-1 (HO-1) is known to induce alternative macrophage activation towards an anti-inflammatory M2 phenotype, the underlying mechanisms remain elusive. Autophagy may play…2015 American Transplant Congress
MiR-26a Regulates Mouse Hepatocyte Proliferation By Directly Targeting Their 3′ Untranslated Region of CCNE2/CCND2
Objectives: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…
American Transplant Congress abstracts