2018 American Transplant Congress
Klotho Enhances FoxO3-Mediated Manganese Superoxide Dismutase Expression by Negatively Regulating PI3K/AKT Pathway during Tacrolimus-Induced Oxidative Stress
Mammalian members of the forkhead box protein O (FoxO) class of transcription factors are implicated in the regulation of oxidative stress, and FoxO proteins are…2018 American Transplant Congress
The Incidence and Risk Factors for Non – Adherence to Medical Treatment among Patients after Kidney Transplantation
Background: Nonadherence to medical treatment is an important risk factor for acute rejection and graft loss. In this study we sought to determine the prevalence…2018 American Transplant Congress
Impact of Aberrant Post-Transplant Laboratory and Blood Pressure Values on Graft Survival and Racial Disparities in Kidney Transplant
Objective: The aim of this study was to assess the impact of post-transplant lab and blood pressure (BP) clinical data on graft survival and racial…2018 American Transplant Congress
Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model
Plastic and Reconstructive Surgery, Shanghai Ninth Hospital, Shanghai, China.
Background: Induction of tolerance and minimizing the toxicity of immuno- suppression are two fundamental goals in vascularized composite allotrans- plantation. Accumulating data indicate that triptolide…2018 American Transplant Congress
Validation of Genetic Variants Identified in GWAS for Tacrolimus Troughs
Purpose: Tacrolimus (TAC) is a substrate for CYP3A4/5 enzymes. It is well-known that variants in these genes are associated with variability in TAC trough concentrations.…2018 American Transplant Congress
Does One Size Fit All? Implementing a Protocolized Ambulatory Tacrolimus Dosing Strategy in a Predominantly African American Renal Transplant Population
Medical University of South Carolina, Charleston, SC.
Introduction: African American (AA) KTx recipients have significant tacrolimus (FK) inter patient variability making protocolized dosage adjustment challenging. We sought to evaluate the efficacy &…2018 American Transplant Congress
Assessment of Peak Levels and Metabolism Rates in African American (AA) and Non-AA Kidney Transplant Recipients (KTR) on Immediate-Release Tacrolimus (IR-tac)
Trough-to-daily dose (C/D) ratio has been used as a simple method for evaluation of IR-tac metabolism rate. Recent studies have shown that fast metabolizers defined…2018 American Transplant Congress
Long-Term Effects of Ketoconazole in Rapid Tacrolimus Metabolizers Post-Renal Transplantation
Introduction: Genetic polymorphisms in cytochrome P-450 enzymes can cause variations in tacrolimus (tac) metabolism. Ketoconazole (keto), a potent CYP450 and P-glycoprotein inhibitor, can be used…2018 American Transplant Congress
Time within Therapeutic Range: A Comparison of Three Tacrolimus Formulations in Renal Transplant Recipients
University of Illinois Hospital & Health Sciences System, Chicago, IL.
Purpose: To compare three formulations of tacrolimus (TAC) and assess differences in time within therapeutic range (TTR) and variability in levels.Methods: Renal transplant recipients from…2018 American Transplant Congress
Evaluation of Tacrolimus Extended-Release in African American Renal Transplant Recipients
University of Maryland, Baltimore.
Purpose: Limited data exists to guide appropriate dosing strategies for novel tacrolimus formulations, such as tacrolimus XL (Astagraf XL). This is especially true in the…
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