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Articles tagged "FK506"

  • 2015 American Transplant Congress

    Conversion from Immediate to Prolonged Release Tacrolimus Did Not Change Intra-Patient Variability in Renal Transplant Patients

    T. El-Nahhas,1,2 M. Moreton,2 J. Popoola,3 S. Abat,3 A. Johnston,1,2 I. MacPhee.3

    1Clinical Pharmacology Department, William Harvey Research Institute, Barts and The London, Queen Mary University of London, London, United Kingdom; 2Analytical Services International, St. George's University of London, London, United Kingdom; 3Institute of Medical and Biomedical Education-Renal Medicine, St. George's University of London, London, United Kingdom.

    Background. Tacrolimus has a narrow therapeutic index and is characterized by a large inter- and intra-patient variability (IPV). Variable blood tacrolimus concentrations have been shown…
  • 2015 American Transplant Congress

    Tacrolimus for the Treatment of Refractory Biopsy-Proven Acute Cellular Rejection in Patients on Belatacept-Based, CNI- and Steroid-Free Immunosuppression Regimens

    K. Trobaugh,1 A. Shields,1,2 S. Tremblay,1 R. Alloway,1 M. Cardi,2 D. Witte,1 F. Paterno,1 M. Cuffy,1 E. Woodle.1

    1Univ of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati.

    Background: Tacrolimus (TAC) is effective as rescue treatment (tx) in renal transplant patients (pts) on cyclosporine-based immunosuppression (IS) who have recurrent or resistant acute rejection…
  • 2015 American Transplant Congress

    Alemtuzumab Induction Is Protective Against Acute Rejection in Kidney Recipients With Subtherapeutic Tacrolimus Concentrations

    K. Szempruch, R.-A. Lee, R. Dupuis, J. Deyo, T. Kozlowski.

    Transplant Surgery, University of North Carolina Hospitals, Chapel Hill, NC.

    Purpose: To determine the effect of attaining early therapeutic tacrolimus (TAC) trough concentrations on biopsy-proven acute rejection (BPAR) within 12 months post-transplantation in adult kidney…
  • 2015 American Transplant Congress

    Long-Term Follow-Up After Conversion from Twice-Daily Tacrolimus Formulation to Once-Daily Tacrolimus Formulation in Pediatric Kidney Transplantation

    C. Choi, A. Han, S. Min, S.-K. Min, T. Lee, I.-M. Jung, S. Kim, J. Ha.

    Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.

    PurposeTacrolimus is one of the most frequently used immunosuppressants in pediatric kidney transplantation (KT) as in adult. In Pediatric kidney recipients, it is more important…
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