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Articles tagged "Epstein-Barr virus (EBV)"

  • 2016 American Transplant Congress

    Identification of MicroRNAs in EBV+ B Cell Lymphomas and Secreted Exosomes.

    V. Kaul, A. Harris-Arnold, C. Esquivel, O. Martinez, S. Krams.

    Division of Abdominal Transplantation, Dept. of Surgery, Stanford University, Stanford.

    Introduction Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation commonly associated with Epstein Barr virus (EBV) infection. EBV viral loads are…
  • 2016 American Transplant Congress

    Examining the Risk for Post-Transplant Viral Infections and Lymphoproliferative Disorder (PTLD) in Kidney Transplant Patients (Pts) Receiving Calcineurin Inhibitor-Based Immunosuppression (CNI-IS) Compared to Belatacept (CTLA4Ig).

    B. Shin, J. Choi, J. Kahwaji, S. Ge, D. Thomas, A. Vo, O. Galera, R. Villicana, A. Peng, S. Jordan, M. Toyoda.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: CTLA4Ig is a novel IS agent that acts through costimulatory blockade of T-cells and obviates the need for CNI. Despite benefits in improving renal…
  • 2016 American Transplant Congress

    Integrative, Multi-Cohort Analysis of Epstein-Barr Virus (EBV)-Positive and Negative Tumor Samples to Identify Gene-Signatures Associated with EBV Oncogenesis.

    E. Maloney, E. Bongen, F. Vallania, N. Kotecha, P. Khatri, O. Martinez.

    Stanford School of Medicine, Stanford, CA.

    EBV is linked to a variety of lymphoid and epithelial malignancies. In transplant recipients EBV is associated with the development of B cell lymphomas in…
  • 2016 American Transplant Congress

    Targeting the Constitutively Active PI3K/Akt/mTOR Signaling Pathway in Epstein-Barr Virus B Cell Lymphomas.

    A. Sang, G. Ivison, C. Esquivel, S. Krams, O. Martinez.

    Division of Abdominal Transplantation, Stanford School of Medicine, Stanford, CA.

    Epstein-Barr virus (EBV) B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD) is a major problem in organ transplantation. Reduction of immunosuppression sometimes result in tumor…
  • 2015 American Transplant Congress

    The Role of Antiviral Prophylaxis for the Prevention of Epstein-Barr Virus (EBV) Associated Post-Transplant Lymphoproliferative Disease (PTLD) in Solid Organ Transplant Recipients: A Systematic Review

    M. AlDabbagh,1,2 M. Gitman,3 D. Kumar, A. Humar, C. Rotstein, S. Husain.1,3

    1Medicine, Division of Infectious Diseases, University Health Network, Toronto, On, Canada; 2Pediatrics, Division of Infectious Diseases, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia; 3Multi-Organ Transplant Unit, University Health Network, Toronto, ON, Canada.

    Background The role of antiviral prophylaxis in EBV seronegative solid organ transplant recipients receiving organs from seropositive donors for prevention of PTLD remains controversial. We…
  • 2015 American Transplant Congress

    Clinical and Virologic Outcomes in High-Risk Adult EBV D+/R- Organ Transplant Recipients

    D. Kumar, N. Patil, S. Husain, C. Chaparro, A. Humar.

    UHN, Toronto, Canada.

    Background:EBV D+/R- organ transplant recipients are a high risk group for developing PTLD. This subgroup of patients has been primarily evaluated in pediatric populations with…
  • 2015 American Transplant Congress

    Epstein Barr Virus Modulates Host Cell MicroRNA-194 to Promote IL-10 Production in B Cell Lymphomas

    A. Harris-Arnold, S. Schaffert, O. Hatton, C. Esquivel, S. Krams, O. Martinez.

    Surgery/Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA.

    Epstein Barr virus (EBV) infection is associated with the development of post-transplant lymphoproliferative disorder (PTLD) which can manifest as aggressive B cell lymphomas in transplant…
  • 2015 American Transplant Congress

    Post-Transplant Lymphoproliferative Disorders Following Alemtuzumab Induction in Kidney Transplantation

    H. Sawhney, R. Charif, J. Galliford, A. Mclean, D. Taube.

    Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, England, United Kingdom.

    Post-Transplant Lymphoproliferative Disorder (PLTD) is a well-recognised serious complication in renal transplant recipients. Induction with lymphocyte depleting agents such as thymoglobulin has been associated with…
  • 2015 American Transplant Congress

    B Cell MicroRNA as Biomarkers for Epstein-Barr Virus Associated Post-Transplant Lymphoproliferative Disorder

    A. Harris-Arnold, V. Kaul, S. Shaffert, O. Hatton, C. Esquivel, S. Krams, O. Martinez.

    Surgery/Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA.

    Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation and is commonly associated with Epstein Barr virus (EBV) infection. EBV viral loads…
  • 2015 American Transplant Congress

    Genetic Diversity Epstein-Barr Virus Latent Gene EBNA-1 Among Transplant Patients and Patients With Infectious Mononucleosis

    K. Sullivan,1 S. Isabel,1 E. Maria,1 P. Tara,1 Y. Simon,1 K. Nasser,1 N. Vicky,2 A. Upton.1

    1Department of Infections Diseases, Hospital for Sick Children, Toronto, ON, Canada; 2Transplant Centre, Hospital for Sick Children, Toronto, ON, Canada.

    Introduction:-The distribution of Epstein Barr Virus (EBV)-associated pathologies varies worldwide. It is associated with the majority of cases of post-transplant lymphoproliferative disorder (PTLD). The EBNA-1…
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