Articles tagged "Epstein-Barr virus (EBV)"

2018 American Transplant Congress
Genomic Diversity of Epstein Barr Virus in Post-Transplant Lymphoproliferative Disorder
E. Maloney,¹ V. Busque,² S. Hui,² S. Krams,^1,2 C. Esquivel,^1,2 O. Martinez.^1,2
¹Stanford Immunology, Stanford University School of Medicine, Stanford, CA; ²Department of Surgery/Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA.
Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We utilized next-generation sequencing…
2018 American Transplant Congress
Prospective Analysis of EBV+ PTLD Incidence in Pediatric Transplant Recipients in the Modern Era
O. Martinez,¹ S. Krams,¹ M. Lapasaran,¹ S. Boyd,² D. Bernstein,² C. Twist,³ K. Weinberg,² D. Gratzinger,² B. Tan,² B. Armstrong,⁴ D. Ikle,⁴ M. Brown,⁵ M. Robien,⁵ C. Esquivel,¹ The CTOTC-06 Investigators.
¹Surgery/Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford; ²Stanford University School of Medicine, Stanford; ³Roswell Park, Buffalo; ⁴Rho, Chapel Hill; ⁵NIAID/NIH, Bethesda.
Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOTC)-06 is an NIAID-sponsored…
2018 American Transplant Congress
Detection of Different Gene Expression Profiles in CD8⁺ T Cells from Chronic High EBV Load Carriers after Pediatric Heart and Liver Transplantation
M. Yamada,^1,2 C. Macedo,² X. Gu,² M. Michaels,^1,2 M. Green,^1,2 C. Nguyen,^1,2 U. Chandran,³ B. Feingold,^1,2 G. Mazariegos,^1,2 D. Metes.^1,2
¹Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ²Thomas E. Starzl Transplantation Institute, Pittsburgh, PA; ³Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA.
Background: EBV infection and post-transplant lymphoproliferative disorders (PTLD) are life-threatening complications of pediatric solid organ transplantation (Tx). The risk for PTLD varies by transplanted organ,…
2018 American Transplant Congress
Viral-Specific Cytotoxic T-Cell (Viral-Tc) Responses in Highly-HLA-Sensitized Patients (HS) Maintained on Tacrolimus and Everolimus Post-HLAi Kidney Transplant
S. Ge,¹ M. Chu,¹ A. Karasyov,¹ D. Lovato,¹ J. Kahwaji,² A. Vo,¹ J. Choi,¹ S. Louie,¹ S. Jordan,¹ M. Toyoda.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Kidney Transplantation, Kaiser Permanente Medical Center, Los Angeles, CA.
Introduction: Viral infections represent significant infectious complications post- kidney transplant which may be increased with desensitization. CMV, EBV and BKV infections are the most prevalent.…
2018 American Transplant Congress
Peptides Encoded by EBV Latent Cycle Proteins Affect NK Cell Reactivity
B. Mbiribindi, C. Romero Moreno, C. Esquivel, O. Martinez, S. Krams.
Department of Surgery, Stanford University School of Medicine, Stanford, CA.
Introduction: Epstein–Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…
2018 American Transplant Congress
Do We Need to Worry about EBV DNAemia in the Late Post-Transplant Period?
M. Morton,¹ K. Daga,² P. Klapper,² M. Picton,¹ P. Vallely.²
¹Department of Renal Medicine, Manchester Royal Infirmary, Manchester, United Kingdom; ²University of Manchester, Manchester, United Kingdom.
Background: Despite detectable Epstein-Barr virus (EBV) in blood, kidney transplant patients (KTR) may have no apparent clinical consequence. This study aims to explore the clinical…
2018 American Transplant Congress
Lymphocyte Proportions Post Thymectomy Are Associated with Allergic Disorders in Heart Transplanted Children
T. Kim,¹ L. Ionescu,^1,2,3 N. Avdimiretz,⁴ M. Larsen,^1,2,3 F. Murdoch,^1,2 B. Motyka,^1,2,3 S. Gilmour,^1,2 L. West,^1,2,3 S. Urschel.^1,2,3
¹Pediatrics, University of Alberta, Edmonton, AB, Canada; ²Stollery Children's Hospital, Edmonton, AB, Canada; ³Alberta Transplant Institute, Edmonton, Canada; ⁴The Hospital for Sick Children, Toronto, Canada.
Background: Allergic disorders are more common in pediatric heart transplant (HTx) recipients than non-transplanted children, with young age at HTx and thymectomy being risk factors.…
2018 American Transplant Congress
Decreased Post Heart Transplant Survival with Epstein-Barr Virus Mismatch in the Current Era
M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, S. Mersola, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Epstein-Barr virus (EBV) has been implicated in a multitude of cancers, including B-cell lymphoma, Burkitt's lymphoma, CNS lymphoma, gastric cancer and nasopharyngeal carcinoma. Previous…
2018 American Transplant Congress
Survival, Cancer and PTLD Diagnosis after Late EBV Infection in Adult Kidney Transplantation
M. Morton,¹ G. Scullin,² K. Daga,² P. Klapper,² P. Vallely,² M. Picton.¹
¹Department of Renal Medicine, Manchester Royal Infirmary, Manchester, United Kingdom; ²Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom.
Introduction: While EBV seronegative recipients have a high risk of early PTLD knowledge is lacking regarding the implications of EBV DNAemia in stable patients in…
2018 American Transplant Congress
Follow-Up and Outcomes of Epstein-Barr Virus Negative Recipients after a Kidney Transplant from an Epstein-Barr Virus Positive Donor
C. Dudreuilh, E. Asgari, R. Hilton.
Departments of Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Introduction: Post-transplant lymphoproliferative disorder (PTLD) is one of the most serious complications of chronic immunosuppression after an organ transplant. One of the major risk factors…

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