ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Epstein-Barr virus (EBV)"

  • 2019 American Transplant Congress

    Post-Transplant Lymphoproliferative Disorders after Living-Donor Liver Transplantation: A Retrospective Cohort Study in 1,900 Cases of Single Center Experience

    T. Tajima1, K. Hata1, H. Haga2, M. Nishikori3, J. Kusakabe1, I. Tamaki1, T. Ito1, T. Kaido1, A. Takaori-Kondo3, S. Uemoto1

    1Div. of HBP Surgery and Transplantation, Dept. of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Dept. of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan, 3Dept. of Hematology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    *Purpose: Post-transplant lymphoproliferative disorders (PTLD) is relatively rare but the most common, life-threatening neoplasms after organ transplantation. Because of their heterogeneity from benign to malignant…
  • 2019 American Transplant Congress

    Post-transplant Lymphoproliferative Disorder Following Intestine Transplantation: Contemporary Single Center Experience

    A. Zimmerman, J. Hawksworth, A. Kroemer, P. Radkani, K. Khan, S. Kaufman, N. Yazigi, S. Subramanian, T. Fishbein, C. Matsumoto

    Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC

    *Purpose: The purpose of this study was to examine the characteristics and risk factors for PTLD after intestinal transplant.*Methods: Retrospective review of intestinal transplant recipients…
  • 2019 American Transplant Congress

    EBV+ PTLD in the Modern Immunosuppression Era: Role of EBV Serology and DNAemia-Preliminary Data from CTOT-C06

    O. M. Martinez1, S. M. Krams1, M. A. Robien2, M. Lapasaran1, S. D. Boyd1, B. Armstrong3, C. Twist4, K. Weinberg1, D. Gratzinger1, B. Tan1, M. Sever3, D. Ikle3, M. Brown2, D. Bernstein1, C. O. Esquivel1

    1Stanford University Sch of Med, Stanford, CA, 2NIAID/NIH, Rockville, MD, 3Rho, Chapel Hill, NC, 4Roswell Park, Buffalo, NY

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is an…
  • 2019 American Transplant Congress

    Lower Rates of Epstein-Barr Virus Viremia and Post-Transplant Lymphoproliferative Disease in Pediatric Solid Organ Transplant Recipients Who Received Valganciclovir Prophylaxis

    E. A. Moulton1, M. Karandikar2, S. Bond3, S. Burchett2, T. Sharma2, F. M. Marty3

    1Baylor College of Medicine, Houston, TX, 2Boston Children's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    *Purpose: Antiviral prophylaxis to prevent post-transplant lymphoproliferative disease (PTLD) remains controversial, but some data suggest that valganciclovir or ganciclovir use in Epstein-Barr virus (EBV) high-risk…
  • 2019 American Transplant Congress

    Regulation of Host microRNA Expression by Natural Variants of Epstein Barr Virus (EBV) Latent Membrane Protein 1 (LMP1)

    O. Hatton1, A. Harris-Arnold2, A. Hui2, E. Maloney2, S. M. Krams2, O. M. Martinez2

    1Molecular Biology, Colorado College, Colorado Springs, CO, 2Program in Immunology and Department of Surgery, Stanford University, Stanford, CA

    *Purpose: Malignancies attributable to EBV, such as post-transplant lymphoproliferative disorder (PTLD), represent 1.8% of global cancer deaths. PTLD occurs in 1-20% of transplant recipients and…
  • 2019 American Transplant Congress

    Mass Cytometry-Based Characterization of Adaptive Immunity in Transplant Recipients with Self-Limiting or Chronic EBV Viremia

    V. H. Ferreira1, C. J. Guidos2, A. Humar1, D. Kumar1

    1UHN, Toronto, ON, Canada, 2SickKids Research Inst, Toronto, ON, Canada

    *Purpose: SOT recipients are at high risk for EBV-associated PTLD. EBV viremia is a risk factor for PTLD. In some patients viremia is self-limited while…
  • 2019 American Transplant Congress

    Ex-Vivo Perfusion Mediated Delivery of Rituximab to Clear Latent Epstein-Barr Virus

    T. Ku, M. Cypel, R. V. Ribeiro, V. H. Ferreira, D. Kumar, A. Humar

    UHN, Toronto, ON, Canada

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) can manifest as a B-cell malignancy associated with Epstein-Barr virus (EBV) infection. Risk of PTLD is greatest in EBV D+/R-…
  • 2019 American Transplant Congress

    Impact of Cytomegalovirus on the Immune System of Healthy Humans

    W. Zhang, J. Robertson, G. Karadkhele, B. Johnson, C. Larsen

    Emory Transplant Center, Emory University, Atlanta, GA

    *Purpose: CMV is a frequent pathogen after transplantation. 2/3 of recipients harbor latent CMV and are at moderate risk. CMV- recipients divide into high or…
  • 2019 American Transplant Congress

    Antithymocyte Globulin is Associated with Mature T Cell Phenotypes and Decreased Risk of Non-EBV Infections in Transplanted Children

    B. I. Shaw1, L. Stempora1, C. Chan1, R. B. Ettenger2, P. C. Grimm3, H. Lee1, E. F. Reed2, M. M. Sarwal4, B. L. Warshaw5, C. Zhao1, O. M. Martinez3, A. D. Kirk1, E. T. Chambers1

    1Pediatrics/Surgery, Duke University, Durham, NC, 2Pediatrics, University of California, Los Angeles, Los Angeles, CA, 3Pediatrics/Surgery, Stanford University, Palo Alto, CA, 4Pediatrics/Surgery, University of California, San Francisco, San Francisco, CA, 5Pediatrics, Emory University, Atlanta, GA

    *Purpose: Depletional induction therapies are known to reduce the rate of acute rejection; yet data from the US Renal Data System have shown that use…
  • 2019 American Transplant Congress

    Phylogenetic Analysis of the Epstein Barr Virus Nuclear Antigen-1 and Associated Correlates among Canadian Transplant Patients

    M. Abdulnoor1, S. Isabel1, T. Paton1, N. Khodai-Booran1, T. Schechter1, P. Birk2, T. Blydt-Hansen3, B. Foster4, S. Mital1, V. Phan5, S. Urschel6, G. Casallo1, T. Papaz1, L. Hamiwka7, S. Min1, U. Allen1

    1University of Toronto, Toronto, ON, Canada, 2University of Manitoba, Winnipeg, MB, Canada, 3University of British Columbia, Vancouver, BC, Canada, 4McGill University, Montreal, QC, Canada, 5University of Montreal, Montreal, QC, Canada, 6University of Alberta, Edmonton, AB, Canada, 7University of Calgary, Calgary, AB, Canada

    *Purpose: The effect of the genetic diversity of the Epstein-Barr virus (EBV) on clinical outcomes in the transplant setting is important to study. We examined…
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