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American Transplant Congress abstracts

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Articles tagged "Epstein-Barr virus (EBV)"

  • 2020 American Transplant Congress

    Genome-Wide Analysis of Epstein Barr Virus Identifies Variations in the Latency Gene EBNA3C That Are Associated with Post Transplant Lymphoproliferative Disorder

    E. Maloney, J. Toh, S. M. Krams, C. O. Esquivel, O. M. Martinez

    Stanford University Sch of Med, Stanford, CA

    *Purpose: Epstein Barr virus (EBV) is a gamma herpes virus that is associated with a variety of human malignancies including EBV+ B cell lymphomas in…
  • 2020 American Transplant Congress

    Role of CAR-T Cell Therapy in Post Transplant Lymphoproliferative Disorder

    S. Krishnamoorthy, A. Malone, R. Delos Santos, H. Murad, T. Alhamad

    Transplant, Washington University in St. Louis, Saint Louis, MO

    *Purpose: Chimeric Antigen Receptor (CAR) T cells are a genetically modified autologous immunotherapy that uses a patient’s own T cells modified with a chimeric antigen…
  • 2020 American Transplant Congress

    Valganciclovir for Epstein-Barr Virus Prevention after Pediatric Kidney Transplant

    R. Jackson1, S. Mehra2, E. Smith1, C. Peterson2, E. Benefield1, R. Ensign1, J. Sherbotie2, C. Heyrend1

    1Intermountain Healthcare, Salt Lake City, UT, 2University of Utah, Salt Lake City, UT

    *Purpose: Epstein-Barr virus (EBV) infection after pediatric kidney transplant (pKTx) is common and can lead to post transplant lymphoproliferative disorder (PTLD). Valganciclovir (VGN) is used…
  • 2020 American Transplant Congress

    Vira-ome: A Tool for an Unbiased Plasma Virome Analysis of SOT Recipients from Cell-Free DNA Sequences

    R. Sinha, E. Bixler, J. Grantham, M. Altrich, S. Kleiboeker

    R&D, Viracor-Eurofins, Lee's Summit, MO

    *Purpose: Blood virome of healthy individuals is frequently predominated by member of families such as Herpesvirus, Anellovirus and Polyomaviridae. The viral load of commensal species…
  • 2020 American Transplant Congress

    Impact of Immunosuppression Protocol on the Incidence of EBV Viremia and PTLD in Pediatric Kidney Transplant Recipients: A Single Center Experience

    K. Bowers1, V. M. Panzarino1, A. Campos1, J. Buggs2, V. D. Bowers2

    1Pediatrics, USF, Tampa, FL, 2Transplant Surgery, TGH, Tampa, FL

    *Purpose: The purpose of this study was to evaluate the efficacy of an immunosuppression protocol change, which included avoidance of anti-thymocyte globulin for induction and…
  • 2020 American Transplant Congress

    Belatacept Conversion is Safe and Effective in Adolescent and Young Adult Kidney Transplant Recipients

    A. Moudgil, C. Petyak, K. Sgambat

    Nephrology, Children's National Med. Ctr., Washington, DC

    *Purpose: Though tacrolimus (TAC) is a cornerstone of maintenance immunosuppression in kidney transplant recipients, some patients have significant side effects related to TAC. Conversion from…
  • 2020 American Transplant Congress

    Sequence Variations of the LMP1 Protein are Detected in Pediatric Transplant Recipients and May Increase the Risk of EBV Disease

    B. Mbiribindi1, M. Arvedson1, J. Pena1, O. Hatton2, C. Esquivel1, O. Martinez1, S. Krams1

    1Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, 2Molecular Biology, Colorado College, Colorado Springs, CO

    *Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). PTLD is a…
  • 2020 American Transplant Congress

    Epstein-Barr Virus (EBV)+ Post-Transplant Lymphoproliferative Disorder (PTLD) is Associated with Tumor CCL3/CCL4 Expression and an Increase in Tumor-Infiltrating Monocytes

    J. Toh1, F. Vallania1, W. A. Haynes1, G. Bhagat2, F. E. Craig3, S. H. Swerdlow4, T. Tousseyn5, S. M. Krams1, P. Khatri1, O. M. Martinez1

    1Stanford University School of Medicine, Stanford, CA, 2Columbia University Medical Center, New York City, NY, 3Mayo Clinic College of Medicine, Phoenix, AZ, 4University of Pittsburgh School of Medicine, Pittsburgh, PA, 5Katholieke Universiteit Leuven, Leuven, Belgium

    *Purpose: PTLD is a serious post-transplant complication that encompasses a spectrum of abnormal lymphoproliferations, including B cell lymphoma-type PTLDs. Although many are EBV-driven, a significant…
  • 2019 American Transplant Congress

    Epstein Barr Virus DNA Integration in B Cell Lymphomas of Post-Transplant Lymphoproliferative Disorder

    M. C. McPherson, O. M. Martinez

    Surgery, Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA

    *Purpose: Epstein Barr virus-positive (EBV+) B cell lymphomas can arise in immunosuppressed individuals, such as organ transplant recipients in the context of post-transplant lymphoproliferative disorder…
  • 2019 American Transplant Congress

    Genomic Variations in Epstein Barr Virus are Associated with Post-Transplant Lymphoproliferative Disorder

    M. Arvedson, E. Maloney, C. Esquivel, O. Martinez, S. Krams

    Stanford Univ School of Med, Stanford, CA

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression.…
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