ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Epstein-Barr virus (EBV)"

  • 2020 American Transplant Congress

    Impact of Immunosuppression Protocol on the Incidence of EBV Viremia and PTLD in Pediatric Kidney Transplant Recipients: A Single Center Experience

    K. Bowers1, V. M. Panzarino1, A. Campos1, J. Buggs2, V. D. Bowers2

    1Pediatrics, USF, Tampa, FL, 2Transplant Surgery, TGH, Tampa, FL

    *Purpose: The purpose of this study was to evaluate the efficacy of an immunosuppression protocol change, which included avoidance of anti-thymocyte globulin for induction and…
  • 2020 American Transplant Congress

    Belatacept Conversion is Safe and Effective in Adolescent and Young Adult Kidney Transplant Recipients

    A. Moudgil, C. Petyak, K. Sgambat

    Nephrology, Children's National Med. Ctr., Washington, DC

    *Purpose: Though tacrolimus (TAC) is a cornerstone of maintenance immunosuppression in kidney transplant recipients, some patients have significant side effects related to TAC. Conversion from…
  • 2020 American Transplant Congress

    Sequence Variations of the LMP1 Protein are Detected in Pediatric Transplant Recipients and May Increase the Risk of EBV Disease

    B. Mbiribindi1, M. Arvedson1, J. Pena1, O. Hatton2, C. Esquivel1, O. Martinez1, S. Krams1

    1Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, 2Molecular Biology, Colorado College, Colorado Springs, CO

    *Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). PTLD is a…
  • 2020 American Transplant Congress

    Epstein-Barr Virus (EBV)+ Post-Transplant Lymphoproliferative Disorder (PTLD) is Associated with Tumor CCL3/CCL4 Expression and an Increase in Tumor-Infiltrating Monocytes

    J. Toh1, F. Vallania1, W. A. Haynes1, G. Bhagat2, F. E. Craig3, S. H. Swerdlow4, T. Tousseyn5, S. M. Krams1, P. Khatri1, O. M. Martinez1

    1Stanford University School of Medicine, Stanford, CA, 2Columbia University Medical Center, New York City, NY, 3Mayo Clinic College of Medicine, Phoenix, AZ, 4University of Pittsburgh School of Medicine, Pittsburgh, PA, 5Katholieke Universiteit Leuven, Leuven, Belgium

    *Purpose: PTLD is a serious post-transplant complication that encompasses a spectrum of abnormal lymphoproliferations, including B cell lymphoma-type PTLDs. Although many are EBV-driven, a significant…
  • 2020 American Transplant Congress

    Long-Term Safety in Epstein-Barr Virus (EBV)-Seropositive Kidney-Only Transplant Recipients Treated with Belatacept (BELA) in Clinical Practice: Final Study Results from the ENLiST Registry

    C. Larsen1, F. Vincenti2, T. Kou3, C. Shadur4, B. Bresnahan5, S. Jordan6, E. S. Woodle7, N. Goes8, J. Vella9, D. Wojciechowski10, M. Polinsky3, A. Gomez-Caminero3

    1Emory University Transplant Center, Atlanta, GA, 2UCSF Transplant Center, San Francisco, CA, 3Bristol-Myers Squibb, Princeton, NJ, 4Iowa Kidney Physicians, Des Moines, IA, 5Medical College of Wisconsin, Milwaukee, WI, 6Cedars-Sinai Medical Center, Los Angeles, CA, 7University of Cincinnati, Cincinnati, OH, 8Kaiser Permanente, San Francisco, CA, 9Maine Nephrology Associates, PA, Portland, ME, 10University Hospital Kidney and Liver Transplant Clinic, Dallas, TX

    *Purpose: BELA, a selective T-cell costimulation blocker, is approved for the prophylaxis of organ rejection in EBV-seropositive adult kidney transplant recipients. In phase 3 BENEFIT…
  • 2020 American Transplant Congress

    Lifetime Survival Estimates Following Solid Organ Transplantation in the United States

    C. Graham1, M. Skeans2, Y. Ahn2, C. Watson3, A. Barlev4

    1RTI Health Solutions, Research Triangle Park, NC, 2Chronic Disease Research Group, Minneapolis, MN, 3Atara Biotherapeutics, South San Francisco, CA, 4Atara Biotherapeutics, Thousand Oaks, CA

    *Purpose: The Scientific Registry of Transplant Recipients (SRTR) contains detailed patient and graft survival data for all solid organ transplants (SOT) in the United States…
  • 2020 American Transplant Congress

    CMV, EBV and BKV Viremia Rate Varied Depending on the Timing of Conversion to Belatacept (BLT)- from Calcineurin Inhibitor (CNI)-Based Immunosuppression and HLA-Sensitization (HS) Status in Kidney Transplant Patients (KTx Pts)

    B. Shin, N. Ammerman, A. Vo, S. C. Jordan, M. Toyoda, S. Sethi

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Viral infections (VI) represent significant morbidity and mortality factors for KTx Pts. We previously showed more VI in BLT-treated Pts compared with CNI Pts…
  • 2020 American Transplant Congress

    Epstein-Barr Virus-Specific Cytotoxic T Lymphocyte Precursors (EBV-CTLp) after Tab-cel Correlates with Response & Survival in Rituximab Relapsing or Refractory Ebv+ Posttransplant Lymphoproliferative Disease (PTLD)

    R. Shen1, N. Guzman-Becerra1, Y. Sun1, F. Forozan1, S. Prockop2, E. Doubrovina2, R. O'Reilly2, X. Li1, M. Hiremath3, L. Gamelin1, W. Navarro1, B. Aftab1

    1Atara Biotherapeutics, Thousand Oaks, CA, 2Memorial Sloan Kettering Cancer Center, New York, NY, 3Atara Biotherapeutics, South San Francisco, CA

    *Purpose: EBV+ PTLD is often a fatal disease. Tab-cel is an investigational off-the-shelf, allogeneic T-cell immunotherapy specific for EBV antigens. Functional in vivo expansion approximated…
  • 2019 American Transplant Congress

    EBV+ PTLD in the Modern Immunosuppression Era: Role of EBV Serology and DNAemia-Preliminary Data from CTOT-C06

    O. M. Martinez1, S. M. Krams1, M. A. Robien2, M. Lapasaran1, S. D. Boyd1, B. Armstrong3, C. Twist4, K. Weinberg1, D. Gratzinger1, B. Tan1, M. Sever3, D. Ikle3, M. Brown2, D. Bernstein1, C. O. Esquivel1

    1Stanford University Sch of Med, Stanford, CA, 2NIAID/NIH, Rockville, MD, 3Rho, Chapel Hill, NC, 4Roswell Park, Buffalo, NY

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is an…
  • 2019 American Transplant Congress

    Lower Rates of Epstein-Barr Virus Viremia and Post-Transplant Lymphoproliferative Disease in Pediatric Solid Organ Transplant Recipients Who Received Valganciclovir Prophylaxis

    E. A. Moulton1, M. Karandikar2, S. Bond3, S. Burchett2, T. Sharma2, F. M. Marty3

    1Baylor College of Medicine, Houston, TX, 2Boston Children's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    *Purpose: Antiviral prophylaxis to prevent post-transplant lymphoproliferative disease (PTLD) remains controversial, but some data suggest that valganciclovir or ganciclovir use in Epstein-Barr virus (EBV) high-risk…
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