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Articles tagged "Epitopes"

  • 2021 American Transplant Congress

    Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation

    K. Ono, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, N. Tanimine, S. Akimoto, Y. Imaoka, K. Sato, H. Yamane, N. Tsukiyama, R. Ide, T. Mochizuki, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan

    *Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…
  • 2021 American Transplant Congress

    Is Equitable Access to Transplantation Possible in the Era of HLA Epitope Compatibility?

    S. Parto1, J. Lamsatfi2, B. Liu2, A. Bourdiec2, B. Foster2, K. Oualkacha2, F. Claas3, P. Keown4, R. Sapir-Pichhadze5

    1Medicine, McGill University, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada, 3Leiden University Medical Centre, Albinusdreef, Netherlands, 4University of British Columbia, Vancouver, BC, Canada, 5Medicine, McGill University Health Centre, Montreal, QC, Canada

    *Purpose: We applied the calculated Panel of Incompatible Epitopes (cPIE), an algorithm informing on the likelihood of identifying blood group and eplet-compatible donors, to study…
  • 2021 American Transplant Congress

    Non-HLA Antibodies and Eplet Mismatches in Cases with Histological Picture of Antibody-Mediated Rejection with and without HLA Donor-Specific Antibodies

    M. Crespo1, L. Llinás2, D. Redondo2, C. Butler3, J. Gimeno4, M. Pérez-Sáez2, A. Buxeda2, C. Arias2, M. Folgueiras2, S. Sanz2, N. Valenzuela3, E. E. Reed3, J. Pascual2

    1Nephrology and Kidney Transplantation, Hospital del Mar, Barcelona, Spain, 2Nephrology, Hospital del Mar, Barcelona, Spain, 3UCLA Immunogenetics Center, UCLA, Los Angeles, CA, 4Pathology, Hospital del Mar, Barcelona, Spain

    *Purpose: Correlation between antibody-mediated rejection (ABMR) and HLA donor-specific antibodies (DSA) is strong but imperfect in kidney transplant (KT) recipients, raising the possibility of other…
  • 2021 American Transplant Congress

    hlaR,” a Simplified Interface for the HLA Matchmaker Tool

    A. Johnson1, J. Zhang1, H. Gebel2, C. Larsen1

    1Surgery, Emory University, Atlanta, GA, 2Pathology, Emory University, Atlanta, GA

    *Purpose: Functional epitopes, or eplets, represent a set of amino acids within three angstroms of one another that may not be sequentially contiguous but are…
  • 2021 American Transplant Congress

    The Calculated Panel of Incompatible Epitopes (cPIE) in the Service of Equitable Access to Transplantation

    J. Lamsatfi1, B. Bingfan Liu1, S. Parto2, A. Lewin3, K. Oualkacha1, F. Claas4, P. Keown5, R. Sapir-Pichhadze6

    1McGill University, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada, 3Hema-Quebec, Montreal, QC, Canada, 4Leiden University Medical Centre, Albinusdreef, Netherlands, 5University of British Columbia, Vancouver, BC, Canada, 6Medicine, McGill University Health Centre, Montreal, QC, Canada

    *Purpose: To inform on feasibility of eplet matching, we developed the calculated Panel of Incompatible Epitopes (cPIE), an algorithm informing on the likelihood of identifying…
  • 2020 American Transplant Congress

    Extended HLA Typing of Kidney Transplant Pairs is Necessary to Assign Presence of Donor-Specific Anti-HLA Antibodies

    A. Senev1, V. Van Sandt2, M. Naesens1, M. Emonds1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2HILA, Rode Kruis Vlaanderen, Leuven, Belgium

    *Purpose: The need for extended high-resolution (HR) HLA genotyping in solid organ transplantation is currently widely debated due to higher costs and questioned clinical importance.…
  • 2020 American Transplant Congress

    The Eplet-Mismatch Landscape in Kidney Patients and Deceased Donors in British Columbia

    J. Tran1, O. Gunther2, J. Lan1, M. Kadatz1, R. Sapir-Pichhadze3, P. A. Keown1

    1University of British Columbia, Vancouver, BC, Canada, 2Gunther Analytics, Vancouver, BC, Canada, 3McGill University, Montreal, QC, Canada

    *Purpose: Minimizing quantitative donor/recipient mismatch at the HLA epitope level may optimize graft outcomes in renal transplantation, but the degree to which optimal matching can…
  • 2020 American Transplant Congress

    Identification of Eplet Mismatches Associated with De Novo Donor Specific HLA Antibody in a Pediatric Kidney Transplant Cohort

    O. Charnaya, J. Jones, P. Chiang, M. C. Philogene, J. Garonzik-Wang

    Johns Hopkins University, Baltimore, MD

    *Purpose: While optimizing immunological matching will decrease the risk of de novo donor specific HLA antibody (dnDSA) formation and improve long-term graft function in pediatric…
  • 2020 American Transplant Congress

    Can HLA-DQ Molecular Mismatch Analysis Be Used to Predict Generation of De Novo Donor-Specific Antibody at an Individual Patient Level?

    D. Pinelli1, M. Casillas Abundis1, R. Hod Dvorai2, H. McDowell1, A. R. Tambur1

    1Northwestern University, Chicago, IL, 2SUNY Upstate Medical University, Syracuse, NY

    *Purpose: De novo donor-specific antibodies (dnDSA), especially to HLA-DQ, are one of the leading causes of late kidney graft failure. Many investigators have attempted to…
  • 2020 American Transplant Congress

    The Impact of Epitope Mismatch Load and Shared Targeting Epitopes between De Novo Donor Specific Antibody (DSA) and Non-DSA Third Party HLA Antibody on Lung Transplantation Outcomes

    A. Zhang1, D. Good1, D. Thomas1, J. Allen1, K. McCurry2, M. Budev2

    1Allogen Laboratories, Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH

    *Purpose: Rapid advancements in HLA typing and antibody identification technologies allow for enhanced HLA compatibility assessment at the epitope level to aid in the reduction…
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