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American Transplant Congress abstracts

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Articles tagged "Epitopes"

  • 2022 American Transplant Congress

    Adding Epitope Compatibility To Deceased Donor Kidney Allocation Criteria: Recommendations From An Online Public Deliberation

    L. Edwards1, R. Sapir-Pichhadze2, P. Keown3, S. Bryan1

    1School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, 2McGill University, Montreal, QC, Canada, 3Department of Medicine, University of British Columbia, Vancouver, BC, Canada

    *Purpose: With increasing demand for kidneys and a scarce supply, ways to reduce rejection and improve transplant outcomes are needed. One possibility is using epitope…
  • 2022 American Transplant Congress

    Site-Directed Mutagenesis as a Tool to Investigate Immunogenicity of HLA Epitopes for Humoral Alloreactivity

    C. H. Maguire1, P. Crivello2, A. Tambur1

    1Northwestern University, Chicago, IL, 2University Hospital Essen, Essen, Germany

    *Purpose: Molecular mismatch load (MML) analysis has been a proposed approach to assess donor/recipient compatibility in support of organ allocation algorithms. While conceptually appealing, MML…
  • 2022 American Transplant Congress

    HLA DSA May Not Be Detected in Many Solid Organ Recipients

    J. C. Quon1, R. M. Lestz2, J. Menteer2, N. Fotiadis2, L. A. Baxter-Lowe2

    1Keck School of Medicine, Los Angeles, CA, 2Children's Hospital Los Angeles, Los Angeles, CA

    *Purpose: Clinically significant HLA antibodies may not be detected if their unique HLA epitopes are not represented in the single antigen reagents that are routinely…
  • 2022 American Transplant Congress

    Which is More Important for Predicting De Novo DSA Production, B Cell Epitope (EPLET) or T Cell Epitope (PIRCHE) Analysis ?

    T. Kobayashi1, T. Tomosugi2, S. Sakamoto2, S. Ashimine1, K. Iwasaki1, M. Niemann3, E. Spierings4, Y. Miwa1, M. Okumura1, K. Ishiyama1, A. Takeda2, N. Goto2, S. Narumi2, Y. Watarai2

    1Aichi Medical University School of Medicine, Nagakute, Japan, 2Nagoya Daini Red Cross Hospital, Nagoya, Japan, 3PIRCHE AG, Berlin, Germany, 4UMC Utrecht, Utrecht, Netherlands

    *Purpose: De novo donor-specific antibodies (dnDSA) can cause chronic ABMR, resulting in poor prognosis. Recently, mismatch at B cell epitope level, i.e. EPLET mismatch, has…
  • 2022 American Transplant Congress

    Validation of Shared T Cell Epitope Analysis as a Tool to Detect Preformed Donor-Reactive CD4+ Memory T-helper Cells

    T. Tomosugi1, K. Iwasaki2, S. Sakamoto3, K. Ftamura1, M. Okada1, T. Hiramitsu1, N. Goto1, S. Narumi1, Y. Watarai1, T. Kobayashi4

    1Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 2Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagoya, Japan, 3Histocompatibility Laboratory, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 4Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Adaptive immunity creates immunological memory after the first response to a specific foreign antigen including HLA. During this response, adaptive immunity memorizes the molecular…
  • 2022 American Transplant Congress

    High Resolution Typing Can Improve Accuracy and Sensitivity of the Virtual Crossmatch for Sensitized Patients – A Single Center’s Experience

    C. MarElia-Bennett1, V. Rohan2, K. Twombley3, O. Moussa1

    1Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 2Surgery, Medical University of South Carolina, Charleston, SC, 3Medical University of South Carolina, Charleston, SC

    *Purpose: The introduction of solid phase assays has significantly enhanced our ability to execute virtual crossmatches (VXMs). However, this method is not without its shortcomings.…
  • 2022 American Transplant Congress

    Understanding The Modification Of Eplet Mismatch Risk By Immunosuppression Regimen

    A. Johnson1, X. Zhang1, L. Gragert2, C. Larsen1

    1Emory University School of Medicine, Atlanta, GA, 2Tulane University School of Medicine, New Orleans, LA

    *Purpose: Solid organ transplant donor-recipient eplet mismatch has been correlated with subsequent donor specific antibody (DSA) formation, antibody mediated rejection, and overall rejection rates. However,…
  • 2022 American Transplant Congress

    Characterisation of Kidney-Specific Extracellular Vesicles During Isolated Organ Normothermic Machine Perfusion

    J. Ashcroft1, T. L. Williams2, T. R. Elliott1, A. Marton1, S. A. Hosgood1, M. L. Nicholson1, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

    *Purpose: Introduction: Normothermic machine perfusion (NMP) can evaluate and recondition deceased-donor kidneys but accurate biomarkers are needed to assess organ quality and to predict post-transplant…
  • 2021 American Transplant Congress

    The Calculated Panel of Incompatible Epitopes (cPIE) in the Service of Equitable Access to Transplantation

    J. Lamsatfi1, B. Bingfan Liu1, S. Parto2, A. Lewin3, K. Oualkacha1, F. Claas4, P. Keown5, R. Sapir-Pichhadze6

    1McGill University, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada, 3Hema-Quebec, Montreal, QC, Canada, 4Leiden University Medical Centre, Albinusdreef, Netherlands, 5University of British Columbia, Vancouver, BC, Canada, 6Medicine, McGill University Health Centre, Montreal, QC, Canada

    *Purpose: To inform on feasibility of eplet matching, we developed the calculated Panel of Incompatible Epitopes (cPIE), an algorithm informing on the likelihood of identifying…
  • 2021 American Transplant Congress

    Towards National Organ Sharing: Fair Distribution of Eplets in Canada

    S. Parto, B. Liu, W. Klement, S. Oikonomopoulos, I. Ragoussis, R. Sapir-Pichhadze

    McGill University, Montreal, QC, Canada

    *Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…
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