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Articles tagged "Endomyocardial biopsy"

  • 2020 American Transplant Congress

    Foxp3+ Innate and TGF-ß+ Adaptive Regulatory Immune Cells in Quilty Lesions are Associated with Acceptance of Heart Allograft

    S. A. Moore, C. K. Metter, Q. Cai, J. R. Torrealba

    University of Texas Southwestern Medical Center, Dallas, TX

    *Purpose: To evaluate the cellular composition of Quilty lesions in heart transplant biopsies and their association with acceptance or rejection of cardiac allografts.*Methods: This study…
  • 2019 American Transplant Congress

    Reference Ranges Donor-Derived Cell-Free DNA in a Heart Transplant Population

    A. Kao1, S. Dholakia2, M. Deng3

    1Saint Luke's, Kansas City, MO, 2CareDx, Brisbane, CA, 3University of Los Angeles, Los Angeles, CA

    *Purpose: Elevations in donor-derived cell-free DNA (dd-cfDNA) ≥0.20 % in heart transplant recipients (HTR) has been shown to be associated with a probability of acute…
  • 2017 American Transplant Congress

    Antibody Mediated Rejection and Donor Specific Antibodies in Heart Transplant Patients: Single Center Experience.

    P. McMullen II,1 J. Xin,1 N. Brown,1 R. Upchurch,1 J. Weidner,1 S. Fedson,2 A. Husain,1 S. Marino.1

    1Pathology, University of Chicago Medicine, Chicago, IL; 2Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX

    BACKGROUND AND AIMS: Preexisting donor specific antibodies (DSA) cause acute antibody mediated rejection (AMR), which can be avoided during pre-transplant work up. Diagnosis and management…
  • 2016 American Transplant Congress

    Development and Validation of a Molecular Microscope Diagnostic System (MMDx) for Heart Transplant Biopsies.

    P. Halloran,1 D. Kim,1 A. Loupy,2 J.-P. Duong Van-Huyen,2 P. Bruneval,3 L. Potena,4 O. Leone,4 J. Reeve.1

    1University of Alberta, Edmonton, Canada; 2Necker Hospital, Paris, France; 3Hopitaux de Paris, Paris, France; 4Bologna University, Bologna, Italy.

    The diagnosis of heart transplant rejection by histology in endomyocardial biopsies (EMB) is challenging. A molecular system (MMDx) has been developed to assess both T…
  • 2016 American Transplant Congress

    Assessment of Molecular Mechanisms of Non-Transplant Cardiac Hypertrophy in Cardiac Allograft Hypertrophy – An Exploratory Gene Array Study of Myocardial Biopsy Samples.

    R. Araujo-Gutiérrez,1,2 S. Ibarra-Cortez,1,2 M. Park,1 J. Estep,1 G. Ashrith,1 B. Trachtenberg,1 G. Torre-Amione,1 K. Youker,1,2 A. Bhimaraj.1

    1Houston Methodist DeBakey Heart & Vascular Center, Houston, TX; 2Houston Methodist Research Institute, Houston, TX.

    Cardiac Allograft Hypertrophy (CAH) develops in up to 80% of patients as early as six months post-transplant, and is associated with decreased quality of life…
  • 2015 American Transplant Congress

    Inverse Monocytic Subset Profile in Blood and Tissue During Heart Transplant Rejection

    T. van den Bosch,1 M. Kraaij,1 K. Caliskan,2 A. Constantinescu,2 O. Manintveld,2 P. Leenen,3 C. Baan,1 M. van Groningen,4 A. Rowshani.1

    1Department of Internal Medicine, Section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; 2Department of Cardiology, Erasmus Medical Center, Rotterdam, Netherlands; 3Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands; 4Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.

    Introduction: Increased monocytic infiltration of heart transplant tissue is documented during acute rejection. It is still unclear how changes in circulating monocyte pool relate to…

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