2015 American Transplant Congress
Defining the Role of CD57+CD4 T Cells in Belatacept-Resistant Rejection
1Duke University, Durham, NC; 2Emory University, Atlanta, GA; 3Bristol-Myers Squibb, Princeton, NJ.
Purpose: We have shown that CD57+PD1- CD4 T cells are present in higher numbers in the peripheral blood and allograft biopsies of patients who experienced…2015 American Transplant Congress
Peritransplant Costimulation Blockade and Rapamycin Therapy Induces Permanent Limb Allograft Survival
Aim: Using murine models, we sought to identify the mechanisms of responsible for vascularized composite allotransplant (VCA) rejection, and to thereafter, using clinically relevant peri-transplant…2015 American Transplant Congress
Clinically Relevant Anti-TCR mAb Induction Plus Brief Rapamycin Therapy Can Achieve Long-Term Vascularized Composite Allograft (VCA) Survival
Aim: Current strategies for management of VCA recipients are adapted from solid organ transplant protocols, and almost universally employ induction therapy followed by maintenance triple…2015 American Transplant Congress
Interactions Between Platelets and Liver Sinusoidal Endothelial Cells Initiate Liver Regeneration
ObjectivesPlatelets and liver sinusoidal endothelial cells (LSEC) were shown to be important contributors to liver regeneration. Several recent studies suggested that their interactions might be…2015 American Transplant Congress
Overexpression of 2B4 Inhibits the Expansion and Function of Donor-Reactive CD8+ T Cells in Selective Lymphoid Compartments
Department of Surgery, Emory University, Atlanta, GA.
2B4 is an immunoglobulin superfamily member expressed constitutively on NK cells, and inducibly on some CD8+ T cells. We recently showed in a murine skin…
American Transplant Congress abstracts