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Articles tagged "Effector mechanisms"

  • 2019 American Transplant Congress

    Rcor1 and Regulation of Foxp3+ T-Regulatory Cells In Vitro and In Vivo

    Y. Xiong, L. Wang, R. Han, W. W. Hancock

    Children's Hospital of Philadelphia, Philadelphia, PA

    *Purpose: While Foxp3+ T-regulatory (Treg) cells are well established as central players in regulation of allograft acceptance and tolerance, the contributions of several types of…
  • 2018 American Transplant Congress

    An In Vitro Model of Human Antibody-Mediated Rejection Depicts Key Role for NK Cells

    L. Hidalgo,1 M. Racape,2 A. Loupy,2 C. Lefaucheur.2

    1Lab. Med. and Pathology, University of Alberta, Edmonton, AB, Canada; 2Paris Cardiovascular Research Center INSERM, Paris, France.

    AIM: Antibody-mediated rejection (ABMR) is the leading cause of kidney allograft loss but its immune mechanisms are incompletely understood. We sought to examine key interactions…
  • 2017 American Transplant Congress

    Glycolytic and Glutaminolytic Metabolism Supports IL-15 Induced Inflammatory Response of Temra CD8 from Kidney Transplant Recipients.

    T.-M. Doan-Ngoc,1 G. Tilly,1 M. Yap,1 A. Caristan,1 L. Jacquemont,1 R. Danger,1 M. Cadoux,1 S. Bruneau,1 M. Giral,1 P. Guerif,1 B. Nicol,1 A. Garcia,1 D. Laplaud,1 S. Brouard,1 C. Pecqueur,2 N. Degauque.1

    1CRTI UMR1064, INSERM, Nantes, France; 2CRCNA UMR892, INSERM, Nantes, France

    Rational. We have recently shown that the accumulation of TEMRA CD8 in kidney transplant recipients (Tx) is associated with a higher risk of kidney dysfunction.…
  • 2017 American Transplant Congress

    Evaluation of Function and TCR signaling Profile of CD57+ T Cells in Allo-Specific Immunity.

    H. Xu,1 T. Brennan,1 Q. Li,2 A. Kirk.1

    1Department of Surgery, Duke University School of Medicine, Durham, NC; 2Department of Immunology, Duke University School of Medicine, Durham, NC

    Our studies have showed that CD57+ cells are resistant to B7 costimulation blockade (CoB). We hypothesize that CD57+ cells are highly sensitive to T cell…
  • 2017 American Transplant Congress

    Cell-Subset Diversity in Adipose Derived Regenerative Cells Used in Renal Ischemic Reperfusion Injury Treatment.

    R. Lathan,1 R. Ghita,1,2 D. Hillyard,1 P. Mark,1,2 M. Clancy.1,2

    1Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; 2School of Medicine, Dentistry and Nursing, Queen Elizabeth University Hospital, Glasgow, United Kingdom

    Studies in our novel hybrid model of transplantion/ischemic reperfusion injury (IRI) in rat has demonstrated significant improvement in kidney function post injection of adipose-derived regenerative…
  • 2017 American Transplant Congress

    High Eomesodermin Expression Correlates with Potent Human Allo-Reactive CD8+ Effector T Cells.

    A. Perez-Gutierrez, D. Metes, Y. Ono, A. Thomson, M. Ezzelarab.

    Surgery, University of Pittsburgh, Pittsburgh, PA

    BackgroundThe transcription factors Eomesodermin (Eomes) and T-bet are thought to play critical roles in CD8+ effector memory T cell development. However, the role of Eomes…
  • 2016 American Transplant Congress

    Natural Killer Cells Display Functional and Receptor Diversity in Response to Alloantigen.

    O. Hatton,1 T. Shawler,1 C. Blish,2 O. Martinez,1 S. Krams.1

    1Division of Abdominal Transplantation, Dept. of Surgery, Stanford University, Stanford; 2Dept of Medicine, Stanford University, Stanford.

    Natural killer (NK) cells play an important role in the first-line defense against tumor and virus-infected cells. Although “missing-self” suggests NK cells would target foreign…
  • 2016 American Transplant Congress

    Rapamycin (RPM) Synergizes with CD154 mAb and DST to Promote Long-Term Vascularized Composite Allograft (VCA) Survival, but Prevents Induction of Donor-Specific Tolerance.

    L. Wang, Z. Wang, R. Han, T. Bhatti, L. Levin, M. Levine, W. Hancock.

    CHOP & UPenn, Philadelphia.

    Even though CD154 mAb (MR-1) plus donor splenocyte transfusion (DST) is very effective at inducing tolerance of various allografts, such as those of hearts, kidneys…
  • 2016 American Transplant Congress

    Cytokine Networks in Kidney Transplant Patients.

    R. Sabat,1 E. Witte,1 P. Reinke,2 K. Wolk,1 N. Babel.3,4

    1Interdisciplinary Group Molecular Immunopathology, and Psoriasis Research and Treatment Center, Dermatology/Medical Immunology, Charite University Medicine Berlin, Berlin, Germany; 2Department of Nephrology and Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany; 3Medical Clinic I, Marien Hospital Herne, University Clinic Ruhr-University Bochum, Herne, Germany; 4Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany.

    As key mediators of the intercellular communication, cytokines play a crucial role in many processes following transplantation, including inflammation, tissue regeneration, and anti-microbial defense. Locally…
  • 2016 American Transplant Congress

    Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.

    A. Perez-Gutierrez, L. Lu, A. Zahorchak, Y. Ono, A. Thomson, M. Ezzelarab.

    Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.

    Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…
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