2020 American Transplant Congress
Humoral Sensitization Overrides Pregnancy-Induced T Cell Transplantation Tolerance
*Purpose: There are ample clinical data that a major long-term consequence of pregnancy is humoral allosensitization. Paradoxically, pregnancy is also a state of spontaneous allogeneic…2019 American Transplant Congress
Exogenous Erythropoietin Administration Promotes Murine Cardiac Allograft Survival via a Myeloid Cell-Dependent Mechanism
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: Erythropoietin (EPO) ligation of the EPO receptor (EPO-R) homodimer and EPO-R/CD131 heterodimer has protolerogenic effects on alloreactive T cell responses. While prior work, largely…2019 American Transplant Congress
Inhibition of Autophagy Prolongs Recipients Survival through Accelerating CD8+ T Cell Apoptosis in a Rat Liver Transplantation Model
*Purpose: In liver transplantation (LT), acute rejection (AR) remains a common complication that significantly shortens recipient survival although various immunosuppressors have been used in clinical…2019 American Transplant Congress
Application of Small Molecule Fluorescent Probes in Early Activation Imaging of CD8+ T Lymphocytes
Central South University, The Third Xiangya Hospital, Changsha, China
*Purpose: As a subset of T lymphocytes, CD8+ T lymphocytes play a vital role in the body's immune system.CD8+ T lymphocytes are responsible for the…2019 American Transplant Congress
Global Analysis of Fc-gamma Receptors Binding Capacity of Human Leukocyte Antigen Donor Specific Antibody
University of Cincinnati Academic Health Center, Cincinnati, OH
*Purpose: Functional assessment of anti-HLA antibodies has historically been limited to complement-binding assays. However, antibodies are capable of inducing injury by complement-independent mechanisms, including Fc-gamma…2019 American Transplant Congress
Need of a New Formula to Estimate Creatinine Clearance in Immediate Post Kidney Transplant Period with Functioning Allograft
*Purpose: Introduction: Post kidney transplant (KTx), with functioning renal allograft, serum creatinine continues to decrease at a variable rate until it stabilizes after a few…2019 American Transplant Congress
EBV Latent Proteins Encode for Peptides That Prevent Natural Killer Cell Inhibition
*Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…2019 American Transplant Congress
Obesity Induced IL-18 Production Impairs FOXP3+ Treg Function and Increases Risk of Primary Graft Dysfunction in Lung Transplant Recipients
*Purpose: Lung transplantation is a life-saving treatment for terminal lung diseases but long-term outcomes are poor, beginning with possible development of primary graft disease (PGD)…2019 American Transplant Congress
Rcor1 and Regulation of Foxp3+ T-Regulatory Cells In Vitro and In Vivo
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: While Foxp3+ T-regulatory (Treg) cells are well established as central players in regulation of allograft acceptance and tolerance, the contributions of several types of…2019 American Transplant Congress
Blockade of C3aR1 Signaling Suppresses Alloreactive CD8+ T Cell Immunity and Prolongs Murine Cardiac Allograft Survival
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: Activation, differentiation and expansion of alloreactive CD8+ T cells, the dominant effectors that mediate murine heart allograft rejection, requires allorecognition, costimulation, and cytokine-initiated signals.…
American Transplant Congress abstracts