2020 American Transplant Congress
Humoral Sensitization Overrides Pregnancy-Induced T Cell Transplantation Tolerance
*Purpose: There are ample clinical data that a major long-term consequence of pregnancy is humoral allosensitization. Paradoxically, pregnancy is also a state of spontaneous allogeneic…2019 American Transplant Congress
Blockade of C3aR1 Signaling Suppresses Alloreactive CD8+ T Cell Immunity and Prolongs Murine Cardiac Allograft Survival
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: Activation, differentiation and expansion of alloreactive CD8+ T cells, the dominant effectors that mediate murine heart allograft rejection, requires allorecognition, costimulation, and cytokine-initiated signals.…2019 American Transplant Congress
The mIR17-92 Cluster Promotes Costimulation Resistant Effector Memory T Cell-Mediated Alloresponses
1Surgery, Duke University, Durham, NC, 2Immunology, Duke University, Durham, NC
*Purpose: CD57 expression has been shown to identify a subset of memory T cells that are resistant to CD28/B7 costimulation blockade (B7CoB). This study was…2019 American Transplant Congress
Exogenous Erythropoietin Administration Promotes Murine Cardiac Allograft Survival via a Myeloid Cell-Dependent Mechanism
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: Erythropoietin (EPO) ligation of the EPO receptor (EPO-R) homodimer and EPO-R/CD131 heterodimer has protolerogenic effects on alloreactive T cell responses. While prior work, largely…2019 American Transplant Congress
Inhibition of Autophagy Prolongs Recipients Survival through Accelerating CD8+ T Cell Apoptosis in a Rat Liver Transplantation Model
*Purpose: In liver transplantation (LT), acute rejection (AR) remains a common complication that significantly shortens recipient survival although various immunosuppressors have been used in clinical…2019 American Transplant Congress
Application of Small Molecule Fluorescent Probes in Early Activation Imaging of CD8+ T Lymphocytes
Central South University, The Third Xiangya Hospital, Changsha, China
*Purpose: As a subset of T lymphocytes, CD8+ T lymphocytes play a vital role in the body's immune system.CD8+ T lymphocytes are responsible for the…2019 American Transplant Congress
Global Analysis of Fc-gamma Receptors Binding Capacity of Human Leukocyte Antigen Donor Specific Antibody
University of Cincinnati Academic Health Center, Cincinnati, OH
*Purpose: Functional assessment of anti-HLA antibodies has historically been limited to complement-binding assays. However, antibodies are capable of inducing injury by complement-independent mechanisms, including Fc-gamma…2019 American Transplant Congress
Need of a New Formula to Estimate Creatinine Clearance in Immediate Post Kidney Transplant Period with Functioning Allograft
*Purpose: Introduction: Post kidney transplant (KTx), with functioning renal allograft, serum creatinine continues to decrease at a variable rate until it stabilizes after a few…2019 American Transplant Congress
EBV Latent Proteins Encode for Peptides That Prevent Natural Killer Cell Inhibition
*Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…2019 American Transplant Congress
Obesity Induced IL-18 Production Impairs FOXP3+ Treg Function and Increases Risk of Primary Graft Dysfunction in Lung Transplant Recipients
*Purpose: Lung transplantation is a life-saving treatment for terminal lung diseases but long-term outcomes are poor, beginning with possible development of primary graft disease (PGD)…
American Transplant Congress abstracts