ATC Abstracts

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Articles tagged "Drug interaction"

  • 2016 American Transplant Congress

    Schisandra Sphenanthera Extract Facilitates Anti-Tuberculosis Treatment Post Renal Transplantation Through Increasing Bioavailability of Tacrolimus.

    R. Deng,1 L. Zhang,1 L. Liu,1 H. Fu,2 J. Li,1 Q. Fu,1 C. Wang.1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; 2Infectious Medicine Department, Guangzhou Infectious Disease Hospital, Guangzhou, China.

    Background: Hepatoprotective agent Schisandra sphenanthera extract (SchE) facilitates rifampicin-containing anti-tuberculosis (TB) chemotherapy by stabilizing the Tacrolimus (FK506) blood concentration through increasing the oral bioavailability, which…
  • 2016 American Transplant Congress

    Tacrolimus Precision Medicine: Antibiotics Increase Intra-Patient Variability in Tacrolimus Trough Concentrations in Kidney Transplant Recipients.

    Y. Zheng, J. Lee, A. Masand, D. Dadhania, M. Thangamani, M. Suthanthiran.

    Medicine/Nephrology and Hyeprtension, Weill Cornell Medical College, New York, NY.

    BACKGROUND. The gut microbiome impacts drug absorption, metabolism, and distribution and was recently shown to be associated with tacrolimus dosing requirements. Since antibiotics can alter…
  • 2015 American Transplant Congress

    Establishment of Diabetes Modeling in Common Marmoset

    W. Yuan,1 S. Fukuda,1 T. Inoue,2 D. Chujo,1 H. Okochi,1 E. Sasaki,2 M. Shimoda.1

    1National Center for Global Health and Medicine, Tokyo, Japan; 2Central Institute for Experimental Animals, Kawasaki, Japan.

    Background:Diabetic nonhuman primates (NHPs) are considered as the good models for both diabetes mellitus research and islet transplantation research safely into clinical applications. However, there…
  • 2015 American Transplant Congress

    No Pharmacokinetic Interaction Between Pantoprazole and Mycophenolic Acid in Renal Transplant Patents: A Randomized Crossover Study

    O. Rissling, P. Glander, P. Hambach, M. Mai, S. Brakemeier, D. Klonower, F. Halleck, E. Singer, E. Schrezenmeier, M. Duerr, H. Neumayer, K. Budde.

    Department of Nephrology, Charité University Hospital, Berlin, Germany.

    Mycophenolic acid (MPA) is used as an immunosuppressive agent in renal transplant (tx) patients (pts). 2 formulations are on the market: The prodrug Mycophenolate-Mofetil (MMF)…
  • 2015 American Transplant Congress

    Interference of Therapeutic Antibodies Used in Desensitization Protocols On Lymphocytotoxicity Crossmatch Results

    D. Milongo,1,3 G. Vieu,2,4,3 S. Blavy,2,4 A. Del Bello,1,3 F. Sallusto,5 L. Rostaing,1,3 N. Kamar,1,3 N. Congy-Jolivet.2,4,3

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Laboratoire d'Immunologie, CHU de Toulouse, Toulouse, France; 3Université Toulouse III Paul-Sabatier, Toulouse, France; 4Laboratoire d'Immunogénétique Moléculaire, EA 3034, Université Toulouse III Paul-Sabatier, Toulouse, France; 5Department of Urology, CHU Rangueil, Toulouse, France.

    Background: Therapeutic antibodies used to desensitize patients awaiting a human leukocyte antigen (HLA) or ABO-mismatched graft are suspected to interfere with the lymphocytotoxicity crossmatch (LCT-XM)…
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