Articles tagged "Donors"

2018 American Transplant Congress
Donor Hepatectomy Time in Donation after Circulatory Death Donors is an Independent Risk Factor for the Development of Biliary Strictures and Early Graft Loss after Transplantation
O. van Leeuwen,¹ M. van Reeven,² M. Fujiyoshi,¹ V. de Meijer,¹ R. de Kleine,¹ M. de Boer,¹ J. de Jonge,² J. Ijzermans,² W. Polak,² R. Porte.¹
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: Liver transplantation (LT) from donors after circulatory death (DCD) is associated with an increased risk of non-anastomotic biliary strictures (NAS) and early graft loss…
2018 American Transplant Congress
DonorNet and Biases in Decision-Making: An Organ Offer Simulation Study
D. Stewart,¹ J. Lindemans,² J. Schold,³ H. McGehee,¹ J. Kessler,⁴ C. Sullivan,⁴ M. Turner,² K. Mekeel,⁵ C. Berg,² R. Stratta,⁶ R. Formica,⁷ L. Ratner,⁸ D. Klassen,¹ B. Shepard.¹
¹UNOS, Richmond; ²Duke, Durham; ³CCF, Cleveland; ⁴Wharton, Philadelphia; ⁵UCSD, San Diego; ⁶Wake Forest, Winston-Salem; ⁷Yale, New Haven; ⁸Columbia, NY.
Background: Behavioral science research has revealed that the way information is presented can impact decision-making. UNOS has developed a DonorNet-like simulation tool to send hypothetical…
2018 American Transplant Congress
Shared Genetic Ancestry as a Predictor of Medium Term Renal Transplant Outcome in Deceased Donor Transplants
C. Stapleton,¹ On behalf of the UK and Ireland Renal Transplant Consortium, P. Conlon,² G. Cavalleri.¹
¹Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland; ²Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
Sibling transplant pairs have better transplant outcomes than unrelated donor recipient (DR) pairs indicating that shared genetic ancestry between donors and recipients can aid in…
2018 American Transplant Congress
Ex Vivo Bloodless Oxygen Carrier for Perfusion of DCD Kidneys during Subnormothermic Storage
P. Luke,^1,2 M. Richard-Mohamed,² A. Haig,³ R. Mayer,² S. Aquil,² A. Sener,² A. Jevnikar,^1,2 R. Bhattacharjee.^1,2
¹Matthew Mailing Centre for Translational Transplant Studies, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.
Background: Non-oxygenated static or machine perfusion in cold (4[deg]C) remains the gold standard in transplantation and an optimal method of oxygen delivery to ischemic kidneys…
2018 American Transplant Congress
Kidney and Liver DCD Outcomes – A Five Year Review
J. Buggs,¹ J. Boone,² M. Adesunkanmi,² R. Mehta,² E. Rogers,³ A. Kumar,⁴ A. Alsina,¹ V. Bowers.¹
¹Transplant Surgery, Tampa General Medical Group, Tampa General Hospital, Tampa, FL; ²Pre-Med Undergraduate, University of South Florida, Tampa, FL; ³Transplant Research, Tampa General Hospital, Tampa, FL; ⁴Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL.
Background: The demand for organ transplantation exceeds the supply and has led to an increase in use of donation after cardiac death (DCD) solid organs…
2018 American Transplant Congress
Livers from Diabetic Donors Can Safely Be Used in Donation after Circulatory Death Liver Transplantation
I. Brüggenwirth,¹ I. Vasiliauskaire,² A. Westerkamp,¹ W. Polak,² A. Braat,³ R. Porte.¹
¹Surgery, UMCG, Groningen, Netherlands; ²Surgery, Erasmus MC, Rotterdam, Netherlands; ³Surgery, LUMC, Leiden, Netherlands.
Liver grafts from donors with a history of diabetes mellitus (DM) have been associated with reduced graft survival after liver transplantation. Transplantation centers are often…
2018 American Transplant Congress
A Medical Decision Analysis for the Use of Donation after Cardiac Death Donors for Simultaneous Liver-Kidney Transplant
A. Miller, K. Tennankore, B. Kiberd.
Division of Nephrology, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
For patients on the simultaneous liver-kidney transplant (SLKT) waitlist, acceptance of donation after cardiac death (DCD) organs may facilitate earlier transplantation thereby reducing waitlist mortality,…
2018 American Transplant Congress
Examples of the Observer Effect in Transplantation- Unintended Consequences of Regulation and Selected Outcome Metrics
A. Rana, M. Kueht, N. Galvan, R. Cotton, C. O'Mahony, J. Goss.
Abdominal Transplantation, Baylor College of Medicine, Houston, TX.
Introduction: The influence of an observer on the phenomena being observed is designated as the observer effect. It is our aim to demonstrate that an…
2018 American Transplant Congress
Impact of ELAD C3A Cell Conditioned Medium Enhanced Perfusate Fluid on Functional Recovery of Extended Criteria Donor Livers during Normothermic Machine Perfusion
S. Afford,² L. Wallace,² R. Laing,² Y. Botteon,² D. He,³ S. Soundararajan,⁴ D. Mirza,¹ R. Ashley,³ J. Brotherton,³ H. Mergental,¹ D. Reich.⁴
¹Queen Elizabeth Hospital, Birmingham, United Kingdom; ²University of Birmingham, Birmingham, United Kingdom; ³Vital Therapies Inc, San Diego, CA; ⁴Drexel University, Philadelphia.
Reconditioning of donor livers by Normothermic Machine Perfusion (NMP) is already increasing the numbers of transplantable organs from the extended criteria donors. The hepatoblastoma-derived cell…
2018 American Transplant Congress
Donor and Procedural Variability in DCD Liver Transplant: Is It Time to Come to a Consensus?
L. Ruffolo, M. Balceniuk, R. Hernandez Alejandro.
Department of Surgery, University of Rochester Medical Center on Behalf of the IDOL Consortium, Rochester, NY.
Background:Donation after cardiocirculatory death liver transplantation (DCD LT) has re-emerged in part because of insufficient grafts for patients on waiting lists. Unfortunately, DCD LT has…