Articles tagged "Donors, marginal"

2021 American Transplant Congress
Indocyanine Green Fluorescence Imaging Allows Quantification of Ischemic Injury During Porcine Normothermic Ex Situ Perfusion
T. Goto, Y. Noguchi, S. Ganesh, L. Mazilescu, T. Reichman, N. Selzner, M. Selzner
Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Situ Liver Perfusion (NEsLP) is a novel preservation technique for the storage and assessment of grafts retrieved after Donation after Cardio-circulatory Death…
2021 American Transplant Congress
Kidney Transplantation from Marginal Donors: An Increased Risk of Urinary Complication. Study from 10279 Patients
B. Mesnard¹, M. Leroy², J. Hunter³, D. Kervella¹, M. Timsit⁴, L. Badet⁵, P. Glemain¹, E. Morelon⁵, F. Buron⁵, M. Le Quintrec-Donnette⁶, V. Pernin⁶, M. Ladriere⁷, S. Girerd⁷, C. Legendre⁴, A. Sicard⁸, L. Albano⁸, S. De Vergie¹, C. Kerleau¹, T. Prudhomme⁹, J. Rigaud¹, D. Cantarovich¹, G. Blanchot¹, G. Karam¹, M. Giral¹, S. Ville¹, J. Branchereau¹
¹Department of Urology, Chu Nantes, Nantes Université, ITUN, Nantes, France, Nantes, France, ²Department of Urology, Chu Nantes, Nantes Université, France, Nantes, France, ³Department of Urology, Nuffield Department of Surgical Science ,Oxford, Oxford, United Kingdom, ⁴Service de transplantation rénale, Hôpital Necker AP-HP, Paris, France, ⁵Service de transplantation, néphrologie et immunologie clinique, Hôpital Edouard Herriot, Hospices de Lyon, Lyon, France, ⁶Service de néphrologie-soins intensifs-dialyse et transplantation, Hôpital Lapeyronie, Montpellier, France, ⁷Service de transplantation rénale, CHU Brabois, Nancy, France, ⁸Service de néphrologie, Hôpital Pasteur, Nice, France, ⁹Service urologie, andrologie et transplantation rénale, Hôpital Rangeuil, CHU de Toulouse, Toulouse, France
*Purpose: Due to the increasing need of kidneys suitable for transplantation, we have expanded the donor population to include marginal donors (Extended criteria donor, controlled…
2021 American Transplant Congress
Allograft Discard Risk Index for Lung Transplantation
R. M. Reul, G. Loor, P. S. Garcha, A. A. Rana
Baylor College of Medicine, Houston, TX
*Purpose: The demand for donor lungs continues to outpace the supply, yet nearly 80% of donor lungs consented for lung transplantation (LTx) are discarded.*Methods: We…
2021 American Transplant Congress
Hepatic Ferroptosis in Cold Stress and Warm Ischemia-reperfusion: A Novel Therapeutic Target in Liver Transplantation
H. Kojima¹, H. Hirao¹, K. Kadono¹, T. Ito¹, K. J. Dery¹, S. Kageyama², K. Nakamura³, F. M. Kaldas¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²Kyoto University, Kyoto, Japan, ³Nishi-Kobe Medical Center, Kyoto, Japan
*Purpose: Ferroptosis, a newly discovered programmed cell death platform, due to iron-dependent accumulation of lipid peroxides, has been reported to aggravate ischemia-reperfusion (IR) injury in…
2021 American Transplant Congress
Can an Organ Survive for More Than 100 Years Between Donor and Recipient
R. Gruessner, J. Renz, A. C. Gruessner
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: It has been hypothesized that parenchymal grafts have a longer life expectancy than the cardio-cerebro-vascular system. We investigated the occurrence of deceased-donor liver (DDOLT),…
2021 American Transplant Congress
A Randomized, Multicenter, Blinded Study Assessing the Effects of Gaseous Nitric Oxide in an Ex Vivo System of Human Lungs
M. G. Hartwig¹, J. A. Klapper¹, N. Poola², A. Banga³, P. G. Sanchez⁴, J. S. Murala³, J. L. Potenziano²
¹Duke University Medical Center, Durham, NC, ²Mallinckrodt Pharmaceuticals, Bedminster, NJ, ³University of Texas Southwestern Medical Center, Dallas, TX, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: The effects of nitric oxide (NO) on donor lungs during ex vivo lung perfusion (EVLP) have not been studied. We assessed whether the novel…
2021 American Transplant Congress
Normothermic-Hyperthermic Machine Perfusion Could Increase Response to Pharmacological Intervention in Mitigation of Liver Steatosis
F. Zhou, M. Xu, G. A. Upadhya, Y. Lin, W. C. Chapman
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: To study the feasibility of mitigating rat liver steatosis with ex-situ normothermic-hyperthermic machine perfusion using a multi-drug ‘defatting’ combination.*Methods: 16 male Zucker obese rats…
2021 American Transplant Congress
Marginal Allografts in Liver Transplantation Have Very Limited Impact on Length of Stay
C. Goff¹, T. Zhang¹, M. McDonald¹, A. Anand¹, N. Galvan², F. Kanwal³, G. Cholankeril², R. Hernaez³, J. A. Goss⁴, A. Rana²
¹Department of Student Affairs, Baylor College of Medicine, Houston, TX, ²Division of Abdominal Transplantation, Michael E DeBakey Department of General Surgery, Baylor College of Medicine, Houston, TX, ³Division of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX, ⁴Liver Center, Division of Abdominal Transplantation, Department of General Surgery, Baylor College of Medicine, Houston, TX
*Purpose: The purpose of this study was to determine the effect on recipient length of hospital stay following transplantation with marginal allografts as specified by…
2021 American Transplant Congress
Utilization of Donor-Derived Cell-Free DNA Testing in Kidney Transplantation: Do One Month Values Have Any Prognostic Significance?
R. J. Stratta, A. Farney, J. Rogers, G. Orlando, A. Reeves-Daniel, A. Mena-Gutierrez, N. Sakhovskaya, C. Jay
Wake Forest Univ, Winston Salem, NC
*Purpose: Percutaneous renal allograft biopsy is the current gold standard for detecting acute rejection after kidney transplantation (KT). Noninvasive tests such as plasma-based donor-derived cell-free…
2021 American Transplant Congress
Nrf2 Assessment in Discarded Liver Allografts: A Role in Allograft Function and Salvage
O. Ahmed, M. Xu, F. Zhou, A. N. Wein, G. Upadhya, Y. Lin, W. Chapman
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: With mounting pressures to optimize organ availability for transplantation, there is a focus on reducing organ discard and attempting to resuscitate declined grafts for…

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