2021 American Transplant Congress
Allograft Discard Risk Index for Lung Transplantation
Baylor College of Medicine, Houston, TX
*Purpose: The demand for donor lungs continues to outpace the supply, yet nearly 80% of donor lungs consented for lung transplantation (LTx) are discarded.*Methods: We…2021 American Transplant Congress
Hepatic Ferroptosis in Cold Stress and Warm Ischemia-reperfusion: A Novel Therapeutic Target in Liver Transplantation
*Purpose: Ferroptosis, a newly discovered programmed cell death platform, due to iron-dependent accumulation of lipid peroxides, has been reported to aggravate ischemia-reperfusion (IR) injury in…2021 American Transplant Congress
Can an Organ Survive for More Than 100 Years Between Donor and Recipient
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: It has been hypothesized that parenchymal grafts have a longer life expectancy than the cardio-cerebro-vascular system. We investigated the occurrence of deceased-donor liver (DDOLT),…2021 American Transplant Congress
A Randomized, Multicenter, Blinded Study Assessing the Effects of Gaseous Nitric Oxide in an Ex Vivo System of Human Lungs
*Purpose: The effects of nitric oxide (NO) on donor lungs during ex vivo lung perfusion (EVLP) have not been studied. We assessed whether the novel…2021 American Transplant Congress
Normothermic-Hyperthermic Machine Perfusion Could Increase Response to Pharmacological Intervention in Mitigation of Liver Steatosis
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: To study the feasibility of mitigating rat liver steatosis with ex-situ normothermic-hyperthermic machine perfusion using a multi-drug ‘defatting’ combination.*Methods: 16 male Zucker obese rats…2021 American Transplant Congress
Marginal Allografts in Liver Transplantation Have Very Limited Impact on Length of Stay
*Purpose: The purpose of this study was to determine the effect on recipient length of hospital stay following transplantation with marginal allografts as specified by…2021 American Transplant Congress
Utilization of Donor-Derived Cell-Free DNA Testing in Kidney Transplantation: Do One Month Values Have Any Prognostic Significance?
Wake Forest Univ, Winston Salem, NC
*Purpose: Percutaneous renal allograft biopsy is the current gold standard for detecting acute rejection after kidney transplantation (KT). Noninvasive tests such as plasma-based donor-derived cell-free…2021 American Transplant Congress
Nrf2 Assessment in Discarded Liver Allografts: A Role in Allograft Function and Salvage
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: With mounting pressures to optimize organ availability for transplantation, there is a focus on reducing organ discard and attempting to resuscitate declined grafts for…2021 American Transplant Congress
Long-term Outcomes of Donation After Cardiac Death and Living Donor Liver Transplant for Primary Sclerosing Cholangitis: An Analysis of UNOS Registry from 2002-2020
Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI
*Purpose: Use of donation after circulatory death (DCD) grafts is a reported risk factor for worse outcomes after liver transplant (LT) for primary sclerosing cholangitis…2021 American Transplant Congress
Characterizing the Early Impact of the Kidney Accelerated Placement Project on Hard-to-place Kidneys
Johns Hopkins University, Baltimore, MD
*Purpose: In 2019, the OPTN implemented the Kidney Accelerated Placement Project (KAPP) in an effort to increase the utilization of kidneys with a high Kidney…
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