Articles tagged "Donors, marginal"

2019 American Transplant Congress
Hard-to-Place Kidney Offers: Through the Lens of the United Network for Organ Sharing Organ Center
S. M. Noreen, R. S. Brown, M. Lane, B. Wolford, C. A. Humphries
United Network for Organ Sharing, Richmond, VA
*Purpose: In 2016, the rate of deceased donor kidney discard continued to increase to 20%. It is well documented that multiple factors contribute to lower…
2019 American Transplant Congress
Ex Vivo Normothermic Perfusion Of Discarded Human Kidneys Reveals Cold-storage-induced Renal Fibrinogen And Provides A Platform For Therapeutic Repair
J. DiRito¹, S. A. Hosgood², M. Reschke³, M. L. Nicholson², G. T. Tietjen⁴
¹Surgery, Yale University & University of Cambridge, New Haven, CT, ²Surgery, University of Cambridge, Cambridge, United Kingdom, ³Biomedical Engineering, Yale University, New Haven, CT, ⁴Surgery - Transplantation, Yale University, New Haven, CT
*Purpose: The purpose of this study was to: 1) determine the cause of microvascular obstructions that arise during ex vivo normothermic perfusion (NMP) of human…
2019 American Transplant Congress
Dissecting The Role Of Donor Acute Kidney Injury On Molecular Responses Post-transplantation
S. Bontha¹, D. Maluf¹, E. Akalin², L. Gallon³, J. Eason⁴, V. Mas⁵
¹UTHSC, Memphis, TN, ²Albert Einstein Medical College, Bronx, NY, ³Northwestern University, Chicago, IL, ⁴Director of Transplantation, Memphis, TN, ⁵Director of Transplant Research, Memphis, TN
*Purpose: In the current scenario of shortage of donor organs, kidneys with AKI are being used and outcome research reports show that the outcomes could…
2019 American Transplant Congress
Preoperative Marginal Factors Do Not Affect the Medically Complex Living Donors for Kidney Transplantation
T. Hiramitsu, T. Tomosugi, K. Futamura, M. Okada, M. Tsujita, T. Ichimori, N. Goto, S. Narumi, Y. Watarai
Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan
*Purpose: Recently, medically complex living donors with marginal factors including hypertension, dyslipidemia, glucose intolerance, and obesity are increasing. The impact of preoperative marginal factors on…
2019 American Transplant Congress
Listing Practices and Graft Utilization Lag behind Supply of Hepatitis C Positive Deceased Donors for Liver and Kidney Transplant
C. E. Kling¹, J. D. Perkins², S. W. Biggins³, C. Johnson⁴, A. P. Limaye⁵, L. Sibulesky¹
¹Division of Transplant Surgery, University of Washington Medical Center, Seattle, WA, ²Division of Transplant Surgery and Clinical and Bio-Analytics Transplant Laboratory, University of Washington Medical Center, Seattle, WA, ³Divisions of Gastroenterology and Hepatology and Center for Liver Investigation Fostering DiscovEry, University of Washington Medical Center, Seattle, WA, ⁴Division of Nephrology, University of Washington Medical Center, Seattle, WA, ⁵Division of Infectious Disease, University of Washington Medical Center, Seattle, WA
*Purpose: The opioid epidemic resulted in increasing incidence of hepatitis C (HCV) in the general population and more deceased organ donors with HCV in the…
2019 American Transplant Congress
The Degree of Glomerulosclerosis in Procurement Renal Biopsy and its Implications in Predicting Graft Outcomes in Marginal Donor Kidneys
W. Cheungpasitporn¹, W. Chon², E. Island², L. Cummings², J. Forster², N. Leeaphorn²
¹University of Mississippi Medical Center, Jackson, MS, ²Saint Luke's Health System, Kansas City, MO
*Purpose: Percentage of glomerulosclerosis (GS) is a major determinant for kidney discard. However, GS failed to consistently predict graft outcomes across studies in the literature.…
2019 American Transplant Congress
Alpha-1 Antitrypsin Reduces Liver Ischemia Reperfusion Injury during Ex-Vivo Normothermic Machine Perfusion
D. Detelich¹, R. de Vries¹, C. Carroll¹, M. Stein², K. Uygun¹, H. Yeh¹, J. Markmann¹
¹Massachusetts General Hospital, Boston, MA, ²Kamada, Rehovot, Israel
*Purpose: Normothermic machine perfusion is an emerging preservation method in liver transplantation with vast potential as a platform for ex-vivo graft reconditioning. Alpha-1 Antitrypsin (AAT)…
2019 American Transplant Congress
Pharmacological Enhancement of Bile Duct Preservation and Function during Ex-Situ Normothermic Machine Perfusion
Y. L. Boteon, J. Attard, A. P. Boteon, L. Wallace, G. Reynolds, D. Mirza, H. Mergental, R. Bhogal, S. Afford
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
*Purpose: Whilst ex-situ normothermic machine perfusion (NMP) of the liver limits the ischaemic injury to the organ, benefits for biliary complications post-transplantation are not yet…
2019 American Transplant Congress
The Outcomes of Living Donor Kidney Transplantation in Donors or Recipients with Donors’ Renal Arteriosclerotic Lesions on Preoperative Computed Tomography
Y. Miyauchi, T. Noda, N. Miura, T. Kikugawa, T. Saika
Ehime University, Toon, Japan
*Purpose: Living donor kidney transplantation is being increasingly performed with elderly donors. Such elderly donors often have arteriosclerotic lesions (AS) (Figure 1). Whether the outcomes…
2019 American Transplant Congress
The Effect of the Beneficial Activity of α-Lipoic Acid Treatment Depend on the Quality of the Graft Kidneys
F. Osella¹, N. Ambrosi², G. Werber¹, F. Caro², S. Beltramino¹, I. Cabrera¹, G. Hilchenbach¹, L. Diaz Alvarez¹, C. Incardona³, E. Chuluyan², D. Casadei¹
¹Instituto de Trasplante y Alta Complejidad, Buenos Aires, Argentina, ²CEFYBO, UBA, Buenos Aires, Argentina, ³GADOR S.A., Buenos Aires, Argentina
*Purpose: In a previous preliminary study, with a small number of patients, we observed that the treatment of the donor and the recipient with the…