Articles tagged "Donor specific transfusion"

2018 American Transplant Congress
A Phase-I Clinical Trial of Donor-Derived MIC Cell Infusion for the Induction of Donor-Specific Hyporesponsiveness after Living Donor Kidney Transplantation (TOL-1 Study)
C. Morath,¹ A. Schmitt,² C. Kleist,³ V. Daniel,³ G. Opelz,³ C. Süsal,³ F. Fälble,¹ C. Sommerer,¹ L. Wang,² M. Zeier,¹ M. Schmitt,² M. Schaier,¹ P. Terness.³
¹Nephrology, University of Heidelberg, Heidelberg, Germany; ²Hematology, University of Heidelberg, Heidelberg, Germany; ³Transplant Immunology, University of Heidelberg, Heidelberg, Germany.
MIC cells are donor-derived monocytes that gain immunosuppressive properties after incubation with the proliferation inhibitor mitomycin C.PBMCs were harvested from living donors by leukapheresis and…
2018 American Transplant Congress
Donor T Cells Undermine the Graft-Protective Effect of DST Plus Anti-CD154
M. Iglesias, M. Chicco, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins University, Baltimore, MD.
Costimulation blockade (CoB) regimens are a promising immunomodulatory strategy to prevent transplant rejection. However, their efficacy is affected by multiple factors, including still unknown ones.…
2017 American Transplant Congress
Lymph Node Stromal Laminins Differentially Regulate T Cell Activation.
T. Simon, J. Bromberg.
University of Maryland, Baltimore
Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…
2016 American Transplant Congress
PD-L1/PD-L2-Expressing B-1a Cells Inhibit Allo-Reactive T Cells in Mice.
T. Hirose,^1,2 Y. Tanaka,¹ H. Ohdan.¹
¹Transplant Surgery, Hiroshima University, Hiroshima, Japan; ²Urology, Hokkaido University, Sapporo, Hokkaido, Japan.
Donor lymphocyte infusion (DLI) induces donor-specific hypo responsiveness or immune-tolerance among allo-reactive T cells in different organ transplantation models. However, the optimal cell source or…
2016 American Transplant Congress
iNKT Cell Ligands Administered with Bone Marrow Cells Expand Allo-Specific Regulatory T Cells In Vivo and Establish Transplant Tolerance.
S. Miyairi,^1,2 T. Hirai,¹ M. Okumi,¹ Y. Ishii,³ K. Yamazaki,² K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; ³Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Invariant natural killer T(iNKT) cells have the powerful potential to expand regulatory T cells(Tregs), especially when they are presented α-galactosylceramide(aGC) by B cells. We previously…
2016 American Transplant Congress
Lymph Node Stromal Laminins Differentially Regulate T Cell Immunity and Tolerance.
T. Simon, J. Bromberg.
University of Maryland, Baltimore, MD.
Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…
2016 American Transplant Congress
Pre-Transplant Infusion of Extracorporeal Photopheresis Treated Donor Splenocytes Leads to Long-Term Liver Allograft Survival and Donor Specific Tolerance in Rats.
X. Kang,¹ Y. Xie,² X. Yeap,² J. Wang,² J. Schneiderman,² Z. Zhang.²
¹Hepatopancreatobiliary Surgery, The Third Hospital of Jilin University, Changchun, Jilin, China; ²Comprehensive Transplant Center, Northwestern University Feinberg School of Medicin, Chicago, IL.
Extracorporeal photopheresis (ECP), a procedure that exposes isolated WBC to photoactivatable 8-methoxypsoralen and ultraviolet A radiation, is used clinically to treat patients with cutaneous T-cell…
2015 American Transplant Congress
In Vivo Expansion of Donor-Specific Regulatory T Cells by a New Triazolopyrimidine Derivative and Donor-Specific Transfusion
S. Emoto,¹ R. Goto,¹ S. Shibasaki,¹ A. Nagatsu,¹ H. Ono,¹ R. Igarashi,¹ M. Fukai,² T. Shimamura,³ K. Saiga,⁴ M. Murakami,⁵ A. Taketomi,¹ S. Todo,⁶ K. Yamashita.²
¹Gastroenterological Surgery 1, Hokkaido University, Sapporo, Japan; ²Transplant Surgery, Hokkaido University, Sapporo, Japan; ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan; ⁴Nippon Kayaku, Tokyo, Japan; ⁵Institute for Genetic Medecine, Hokkaido University, Sapporo, Japan; ⁶Research Institute, St. Mary Hospital, Kurume, Japan.
Background: We have previously demonstrated that a new triazolopyrimidine derivative, NK026680 (NK) prevents activation/maturation of dendritic cells. This study investigated whether NK together with donor-specific…
2015 American Transplant Congress
IL-2/IL-2 Ab Complex Leads to Long-Term Tolerance in a Treg Dependent DST Model of Skin Allograft Transplantation in Which DST and Timing of the Antibody Complex Are Crucial
G. Zhang,¹ Y. Wang,¹ M. Hu,¹ A. Sawyer,¹ J. Zhou,¹ S. Grey,² S. Alexander.¹
¹Children's Hospital at Westmead, Sydney, Australia; ²Garvan Institute, Sydney, Australia.
Background: In vivo Treg expansion using IL2 complexed with anti-IL2 antibody has been demonstrated to be effective in the induction of long-term acceptance of islet…
2015 American Transplant Congress
Mesenchymal Stem Cells (MSCs) Transfusion for Desensitization of Positive Lymphocyte Cross Match (LCM) or Panel Reactive Antibodies (PRA) Before Kidney Transplantation – Outcome of 16 Cases
G. Saadi,¹ K. Eweda,² M. Hassaballa,¹ F. Fadel,³ E. Aziz,² M. Roshdi,¹ M. El Ansary,⁴ I. Aziz,⁴ W. Ismail,⁵ A. Atef,¹ S. Hamid.⁴
¹Internal Medicine and Nephrology, Cairo University, Cairo, Egypt; ²Nephrology, Army Hospital, Cairo, Egypt; ³Pediatric Nephrology, Cairo University, Cairo, Egypt; ⁴Clinical Pathology, Cairo University, Cairo, Egypt; ⁵Pathology, Beni Sweif University, Beni Sweif City, Egypt.
Immunomodulatory function of MSCs may correct positive PRA or LCM in highly-sensitized patients. We evaluate donor specific or 3rd party MSCs transfusion in 16 patients…