ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Donor specific transfusion"

  • 2022 American Transplant Congress

    Depletion of Donor Macrophages Permits Post-Transplant Tolerance Induction

    M. Dilts1, A. Dangi2, X. Luo3

    1Pathology, Duke University, Durham, NC, 2Medicine, Duke University, Durham, NC, 3Duke University School of Medicine, Durham, NC

    *Purpose: Using donor splenocytes fixed with cross-linker ethylcarbodiimide (ECDI-SPs), our lab has induced tolerance in a variety of murine and non-human primate models when one…
  • 2020 American Transplant Congress

    Role of B-Cell Subsets in Allograft Rejection in Intestinal Transplantation

    H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. Fishbein, A. Kroemer

    Transplant Institute, MedStar Georgetown University, Washington, DC

    *Purpose: While B-cells contribute to allograft rejection by presenting antigens to T-cells and by producing donor-specific antibodies (DSAs) and various cytokines, their pathophysiology in transplant…
  • 2020 American Transplant Congress

    Infectious Tolerance Depends Upon the ‘Exokine’ IL35

    W. J. Burlingham1, J. A. Sullivan1, Y. Tomita2, E. Jankowska-Gan1, D. Lema1, S. Hong3, D. A. Vignali4

    1Surgery, University of Wisconsin, Madison, WI, 2Surgery, Tokai University, Tokyo, Japan, 3Pharmacy, University of Wisconsin, Madison, WI, 4Immunology, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Interleukin-35 (IL35) is an immunosuppressive cytokine composed of Ebi3 and p35 subunits. Yet the form(s) that IL35 assumes and its role in infectious tolerance,…
  • 2020 American Transplant Congress

    Multifaceted Roles of Follicular T Cell Subsets in Controlling Antibody Mediated Rejection

    M. T. Mohammed

    Renal- Transplant Research Center, Brigham and Women's Hospital- Harvard Medical School, Boston, MA

    *Purpose: Assess the roles of T Follicular Helper and Regulatory cells in controlling pathogenic donor-specific antibodies (DSA) and antibody-mediated rejection(AbMR) during kidney transplantation.*Methods: Here we…
  • 2020 American Transplant Congress

    Altering Homeostatic Repopulation with Thymic Irradiation and Donor Mesenchymal Stem Cell Infusions in a Nonhuman Primate Model

    R. Schmitz, M. S. Mulvihill, Z. W. Fitch, T. How, F. Leopardi, A. D. Kirk

    Department of Surgery, Duke University Medical Center, Durham, NC

    *Purpose: Lymphocyte depletion and subsequent homeostatic repopulation present opportunities to shape the alloreactive immune repertoire to favor tolerance. We tested if the addition of thymic…
  • 2020 American Transplant Congress

    Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo

    G. Huai1, K. M. Lee1, Q. Fu1, K. Deng1, N. J. Feeney1, C. Leguern1, N. Tanimine1, C. G. Rickert1, S. Deng2, J. F. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

    *Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
  • 2019 American Transplant Congress

    A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy

    J. Zuber1, O. Boyer1, B. Neven1, R. Berthaud1, M. Ould Rabah1, I. Jollet2, V. Renac2, F. Pirenne2, S. Gross2, R. Djoudi2, P. Tiberghien2, J. Taupin3, S. Blanche1, R. Salomon1

    1Paris Descartes University, Paris, France, 2Etablissement Français du Sang, Paris, France, 3Department of Immunology and Histocompatibility, St Louis Hospital, Paris, France

    *Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…
  • 2019 American Transplant Congress

    Dichotomous Role Of Donor T Cells In The Efficacy Of Tolerogenic Therapies For Transplant Rejection

    M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi

    Plastic Surgery, Johns Hopkins University, Baltimore, MD

    *Purpose: Costimulation blockade-based regimens are a promising strategy to promote transplant tolerance. However, their efficacy is affected by multiple factors, many of which remain unknown.…
  • 2018 American Transplant Congress

    CTLA4-Ig and Bortezomib Successfully Reverses Established DSA Responses in Allograft-Sensitized Recipients

    D. Jain,1 J. Young,1 D. Yin,1 R. Pelletier,2 A. Chong.1

    1Department or Surgery, University of Chicago, Chicago, IL; 2Department of Surgery, Ohio State University, Columbus, OH.

    Background: Sensitized recipients have lower rates of transplantation and poorer outcomes. We and others have reported that the delayed administration of CTLA4-Ig can disrupt fully-established…
  • 2018 American Transplant Congress

    Shared HLA Specificities between the Blood and Transplant Donor Increases the Risk of De Novo DSA Development Following Blood Transfusion in Transplant Recipients

    S. Hassan,1 F. Regan,2 C. Brown,3 A. Harmer,2 N. Anderson,2 E. Santos,4 P. Brookes,4 D. Taube,1 M. Willicombe.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Haematology, Imperial College Healthcare NHS Trust, London, United Kingdom; 3Histocompatibility and Immunogenetics, NHS Blood and Transplant, London, United Kingdom; 4Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.

    Introduction: Blood transfusions post-transplant have been shown to be associated with the development of de novo DSA and inferior allograft outcomes. The mechanisms behind this…
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