2022 American Transplant Congress
Humoral Response After a Third Dose of Sars-CoV-2 mRNA Vaccine in Transplant Recipients
Brigham & Women's Hospital, Boston, MA
*Purpose: Prior studies demonstrated an increased immune response post-3rd COVID-19 vaccine dose when given 1-month post-2nd dose in solid organ transplant recipients (SOT). This study…2022 American Transplant Congress
Sirolimus Use Is Associated With An Improved Immune Response To Covid-19 Vaccination In Kidney Transplant Recipients
*Purpose: Kidney transplant recipients (KTRs) are highly vulnerable to severe COVID-19, however are poorly protected by vaccination. Additional vaccine doses have achieved limited improvements in…2022 American Transplant Congress
Impact Of Nirmatrelvir-Ritonavir On Tacrolimus Concentrations
1University of Rochester Medical Center, Rochester, NY, 2Tampa General Hospital, Tampa, FL
*Purpose: Ritonavir (RTV), a component of the oral antiviral agent nirmatrelvir-RTV (Paxlovid) for COVID-19 infection, increases tacrolimus concentrations through strong competitive inhibition of gastrointestinal and…2022 American Transplant Congress
Pre-Vaccine Antibodies Against Seasonal Betacoronaviruses Are Associated with Decreased Antibody Response to SARS-CoV-2 mRNA Vaccination in Solid Organ Transplant Recipients
*Purpose: The impact of antigenic imprinting, when immune memory of one antigen influences the response to subsequent similar antigens, on the antibody response in solid…2022 American Transplant Congress
Low T Cell Responsiveness in the Early Phase Of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
*Purpose: Kidney transplant (KT) recipients are more prone to developing life-threatening forms of COVID-19 than the general population. Little is known about the immunological mechanisms…2022 American Transplant Congress
Association of Chest CT Score During Acute COVID-19 Illness with Subsequent Lung Function Loss Among Lung Transplant Patients
University of Texas Southwestern, Dallas, TX
*Purpose: Limited data exists on CT chest abnormalities during acute Coronavirus disease 2019 (COVID-19) infection and associated post-illness loss of lung function among lung transplant…2022 American Transplant Congress
Vitamin D Status and Sars-cov-2 Infection in a Cohort of Renal Transplanted Patients
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Milano, Milano, Italy
*Purpose: Immunomodulatory and anti-inflammatory properties have been hypothesized for native vitamin D (nVD). Very little is reported about nVD and risk of Sars-CoV-2 infection (COV)…2022 American Transplant Congress
Differences in Acceptance to the Kidney Transplant List
*Purpose: During the COVID-19 pandemic, kidney transplant (KT) evaluations shifted from in-person evaluation (IPE) to telemedicine evaluation (TME). Given differences in access to electronics and…2022 American Transplant Congress
Anti-HLA Antibodies Do Not Increase in Kidney Transplant Recipients During COVID-19 Infection
*Purpose: To determine if HLA allo-antibody levels are affected by COVID-19 in renal transplanted patients and to compare the immunoglobulin class and subclass profiles as…2022 American Transplant Congress
The Impact of Frailty Syndrome on Humoral Response to SARS-CoV-2 mRNA Vaccines in Older Kidney Transplant Recipients
*Purpose: Advanced age is associated with impaired humoral immune response to SARS-CoV-2 mRNA vaccines in kidney transplant recipients (KTR), however mechanisms are poorly understood. Frailty…
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