Articles tagged "COVID-19"

2022 American Transplant Congress
Mandatory Vaccine Requirements in Waitlisted Transplant Patients: A Transplant Center’s Perspective – A Call to Action
M. Debroy¹, K. Andreoni¹, A. Beach², K. Chavin¹
¹University Hospitals Cleveland Medical Center/Case Western Reserve, Cleveland, OH, ²University Hospitals, Cleveland, OH
*Purpose: The global pandemic caused by the SARS Cov-2 virus has caused unprecedented, previously unthinkable changes. COVID-19 infection in transplanted patients carries an ~ 30%…
2022 American Transplant Congress
Sars-CoV-2 Antibody Response Before and After Third Dose of Homologous mRNA Vaccine in Liver Transplant Recipients
A. T. Strauss¹, A. Chang¹, J. Alejo¹, T. Chiang¹, L. Zeiser¹, N. Fortune¹, B. Boyarsky¹, R. Avery², A. A. Tobian¹, M. Levan¹, D. S. Warren¹, A. Massie³, J. Garonzik-Wang¹, D. Segev¹, W. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins, Baltimore, MD, ³Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Liver transplant (LT) recipients have a decreased response to 2 doses of SARS-CoV-2 vaccine compared to the general population, so we aimed to understand…
2022 American Transplant Congress
Antibody Response and Molecular Graft Surveillance in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination
N. M. Ali¹, J. Miles², S. Mehta¹, V. Tatapudi¹, Z. Stewart¹, B. Lonze¹, M. Mangiola¹, C. DiMaggio¹, E. Weldon¹, I. Saeed¹, J. Leonard¹, R. Herati¹, J. Thomas¹, J. Michael¹, C. Hickson¹, K. Cartiera¹, R. Montgomery¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, NY
*Purpose: Preliminary studies suggest that kidney transplant recipients (KTRs) show diminished humoral responses to SARS-CoV-2 vaccination. Although reports of allograft rejection after SARS-CoV-2 vaccination have…
2022 American Transplant Congress
SARS-CoV-2 Infection is Associated with Greater Neutralizing Antibody Response Compared to Three Doses of Mrna-1273 Vaccine in Solid Organ Transplant Recipients
V. H. Ferreira, V. Hall, T. M. Marinelli, M. Ierullo, V. Kulasingam, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: Prior studies suggest that two doses of mRNA vaccine in SOTR may result in lower antibody and T-cell responses relative to levels seen following…
2022 American Transplant Congress
Clinical Features and Outcomes of Hospitalized Solid Organ Transplant and Hematopoietic Stem Cell Recipients with Sars-CoV-2 Infection in the Midwestern United States: A Multi-Center Retrospective Cohort Study
S. Tanna¹, D. Florescu², A. Majeed³, J. Banzon³, S. Waller⁴, A. Eid⁴, N. Barros Baertl⁵, D. Friedman⁶, K. Mullane⁷, M. Ison⁸
¹Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, ²University of Nebraska Medical Center, Omaha, NE, ³Cleveland Clinic, Cleveland, OH, ⁴University of Kansas Medical Center, Overland Park, KS, ⁵Infectious Diseases, Indiana University, Indianapolis, IN, ⁶Infectious Diseases, University of Chicago, Chicago, IL, ⁷University of Chicago, Chicago, IL, ⁸Northwestern University Comprehensive Transplant Center, Chicago, IL
*Purpose: Immunocompromised hosts are at risk for severe complications or death from SARS-CoV-2 infection. Few studies describe the clinical features, outcomes and treatment strategies in…
2022 American Transplant Congress
Early Clinical Experience With Alvr109, A Partially Hla-matched Sars-cov-2 Specific T-cell Therapy, In Immunocompromised Patients With Covid-19
G. Haidar¹, J. Jacobs², K. Hughes², K. McCormick², A. Naqvi², M. Agha², T. Bogdanovich², B. Johnson², J. Kozar², E. Lendermon², C. Marino², A. Raptis², F. Silveira², W. Marshall³, M. Miller³, E. Atillasoy³, J. Mellors²
¹University of Pittsburgh, Pittsburgh, PA, ²UPitt, Pittsburgh, PA, ³Allovir, Waltham, MA
*Purpose: Therapies for COVID-19 in immunocompromised (IC) patients (pts), including transplant (tx) pts, are limited. We describe our experience with ALVR109, an allogeneic, partially HLA-matched…
2022 American Transplant Congress
Role of Vaccination in the COVID-19 Nationwide Cohort (N3C) of Solid Organ Transplant Recipients
A. J. Vinson¹, A. Anzalone², R. Dai², E. French³, A. Olex³, J. Sun⁴, G. Agarwal⁵, S. Lee⁶, R. B. Mannon⁷
¹Nova Scotia Health Authority, Halifax, NS, Canada, ²University of Nebraska Medical Center, Omaha, NE, ³Wright Center for Clinical and Translational Research, Richmond, VA, ⁴Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶University of Saskatchewan, Regina, SK, Canada, ⁷Medicine, University of Nebraska Medical Center, Omaha, NE
*Purpose: Immunosuppressed solid organ transplant (SOT) patients have been repeatedly challenged in the COVID-19 pandemic with significant morbidities and mortality following infection and a suppressed…
2022 American Transplant Congress
An Additional Dose Of Viral Vector Covid-19 Vaccine And Mrna Covid-19 Vaccine In Kidney Transplant Recipients: A Randomized Controlled Trial
J. Bruminhent¹, C. Setthaudom², P. Phornkittikorn³, P. Chaumdee³, S. Prasongtanakij⁴, S. Srisala⁴, K. Malathum¹, S. Boongird⁵, A. Nongnuch⁵, M. Assanatham⁵, S. Kiertiburanakul¹
¹Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, ²Immunology Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, ³Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, ⁴Office of Research, Academic Affairs and Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, ⁵Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
*Purpose: An additional dose of the COVID-19 vaccine following a primary series is recommended for solid organ transplant recipients. However, a comparison of the immunogenicity…
2022 American Transplant Congress
Differences in Strength and Longevity of SARS-CoV-2-Specific Adaptive Immunity Between Convalescent and Vaccinated SOT Patients and Immunocompetent Individuals
L. Donadeu¹, S. Gomez¹, A. Fava'², E. Crespo¹, F. Moreso³, M. Lopez³, L. Lladó⁴, J. González⁴, I. Campos³, M. Muñoz³, J. Quintero³, J. Esperalba³, O. Bestard³
¹Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ²Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ³Vall d’Hebron University Hospital (HUVH), Barcelona, Spain, ⁴Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain
*Purpose: Short-term adaptive immune memory has been reported among immunocompetent (IC) and convalescent Solid Organ Transplant (SOT) individuals following SARS-CoV-2 infection as well as after…
2022 American Transplant Congress
Organ Transplant Outcomes from Donors with Positive SARS-CoV-2 PCRs in New York: A Case Series
A. L. Friedman¹, M. Pereira², M. Rana³, J. Akpede⁴, A. Dhand⁵
¹LiveOnNY, New York, NY, ²New York Presbyterian Hospital, New York, NY, ³Icahn School of Medicine at Mount Sinai, New York, NY, ⁴LiveOnNY, Long Island City, NY, ⁵Westchester Medical Center, Chappaqua, NY
*Purpose: Rapid evolution of the SARS-CoV-2 pandemic over the past 24 months has demanded agility in managing selection criteria for deceased organ donors, with the…

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