Articles tagged "COVID-19"

2022 American Transplant Congress
Blood Transcriptomes of Covid-19 Infected Kidney Recipients Demonstrate Frequent and Persistent Sars-cov-2 Virome Gene Expression
Z. Sun¹, M. M. Rana², A. C. Reghuvaran³, Y. A. Azzi⁴, G. Carrara⁵, S. Hartzell⁶, S. Kulkarni³, W. Zhang⁶, K. Banu³, P. Heeger⁶, E. Akalin⁴, P. Cravedi⁶, Z. Zhang⁷, M. C. Menon³
¹Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ²Infectious Disease Director, Icahn School of Medicine at Mount Sinai, New York, NY, ³Nephrology, Yale University, New Haven, CT, ⁴Nephrology, Montefiore Medical Center, New York, NY, ⁵Clinical Research Coordinator, Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Kidney transplant recipients (KTRs) have poor outcomes vs non-KTRs with acute COVID-19. To provide insight into management of immunosuppression during acute COVID-19, we studied…
2022 American Transplant Congress
Preliminary Data of the Safety and Immunogenicity Protocol of Vaccination for SARS-CoV 2 in Solid Organ Transplant Patients in Argentina
S. K. Villamil Cortez¹, J. R. Geffner², L. A. Barcan³, P. Remersano², A. Smud³, A. Villamil⁴, N. C. Imperiali¹, S. R. Groppa¹, C. A. Mombelli¹, V. A. Suarez Muñoz¹, C. Belziti⁵, F. Marcelo⁶, S. Di Pietrantonio⁷, G. J. Rosa Diez¹, M. C. Giordani¹
¹Nephrology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Inmunology, INBIRS CONICET, Buenos Aires, Argentina, ³Infectology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Hepatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁶Nephrology, IOT Clinica de Nefrologia, Misiones, Argentina, ⁷Nephrology, Hospital El Cruce - Nestor Kirchner, Buenos Aires, Argentina
*Purpose: To evaluate the safety and generation rate of Ab anti spike rate in SOT patients at 28 and 90 days after completing the Covid…
2022 American Transplant Congress
Antibody Responses to an Additional Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients with and without HIV
M. Saksena¹, G. Carrara², B. Haydel², A. Azad¹, K. Srivastava¹, C. Gleason¹, K. Beach¹, L. Sominsky¹, A. Oostenink¹, G. Cai¹, J. Carreno Quiroz¹, G. Singh¹, S. Florman², C. Cordon-Cardo³, J. Aberg⁴, A. Wajnberg⁵, F. Krammer¹, V. Simon¹, M. Rana⁴
¹Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, ³Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Solid organ transplant (SOT) recipients mount suboptimal immune responses to a two-dose SARS-CoV-2 mRNA vaccine series. Data regarding antibody responses in HIV and SOT…
2022 American Transplant Congress
COVID-19 Syndrome After Liver Transplant: Immunosuppression Role and Risk Factors for Mortality
M. M. Pascale¹, F. Frongillo¹, G. Bianco¹, F. Galiandro², E. Nure¹, S. Agnes¹, F. Giovinazzo¹
¹General Surgery and Liver Transplant Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy, ²General Surgery Unit, ULSS3 Serenissima, Venezia, Italy
*Purpose: Data on mortality and immunosuppression role regarding Liver transplant recipients affected by COVID-19 are still under debate. The present study identified risk factors for…
2022 American Transplant Congress
Organs from Donors with Positive SARS-CoV-2 NAT+ Testing: A Report from the Ad Hoc Disease Transmission Advisory Committee
L. Danziger-Isakov¹, J. D. Goldman¹, A. Wooley¹, S. Pouch¹, A. Agarwal¹, G. Berry¹, K. Dunn¹, S. Ho¹, M. Kittleson¹, D. H. Lee¹, D. Levine¹, C. Marboe¹, G. Marklin¹, R. Razonable¹, S. Taimur¹, H. Te¹, C. Fox², C. Jett², S. Booker², D. Klassen², R. LaHoz¹
¹OPTN, Richmond, VA, ²UNOS, Richmond, VA
*Purpose: Decision to transplant organs from SARS-CoV-2 NAT+ donors(N+D) balances risk of donor-derived infection with the scarcity of available organs to meet the needs of…
2022 American Transplant Congress
COVID-19 in Solid Organ Transplant: A Global Perspective
.. C19TxR Consortium
ESOT, NHSBT, UNOS, CareDx, South San Francisco, CA
*Purpose: Transplantation has been disrupted dramatically by COVID-19 due to reallocation of healthcare resources and concerns from early reports of increased mortality rates (20-30%) in…
2022 American Transplant Congress
Three Month Antibody Durability and Kinetics in Sars-cov-2 Mrna Vaccinated Heart and Lung Transplant Recipients: Differences Above the Diaphragm
J. L. Alejo¹, J. Ruck¹, T. Chiang¹, A. Abedon¹, J. Kim¹, R. Avery¹, A. Tobian¹, M. Levan¹, D. Warren¹, A. Massie¹, W. Werbel¹, J. Garonzik-Wang², D. Segev¹
¹Johns Hopkins, Baltimore, MD, ²University of Wisconsin, Madison, WI
*Purpose: Heart and lung transplant (HT/LT) recipients have impaired humoral responses to SARS-CoV-2 vaccination compared to other solid organ transplant recipients (SOTRs). The purpose of…
2022 American Transplant Congress
SARS-CoV-2 Antibody Response by mRNA Vaccine Platform in Incrementally Immunosuppressed Patients
J. Mitchell¹, C. Connolly¹, T. Chiang¹, J. Alejo¹, W. Werbel¹, D. Segev¹, A. Massie²
¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: This study compares SARS-CoV-2 antibody responses between the two-dose mRNA-1273 and BNT162b2 vaccine series across groups of incrementally immunosuppressed patients.*Methods: Semiquantitative testing for antibodies…
2022 American Transplant Congress
Comparative Outcomes at a Single Center for 71 Deceased Donor Kidney Transplants from Donors with Sars-CoV-2 RNA Detection
C. E. Koval¹, E. Poggio², M. Eltemamy³, Y. Lin², M. Duck⁴, N. Shrestha⁵, A. Wee²
¹Cleveland Clinic Foundation, Cleveland, OH, ²Cleveland Clinic, Cleveland, OH, ³The Cleveland Clinic, Cleveland, OH, ⁴Nephrology, Cleveland Clinic Foundation, Cleveland, OH, ⁵Infectious Diseases, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Extra-pulmonary organs from donors with SARS-CoV-2 detection during donor evaluation are not accepted by many centers due to theoretical concerns for productive infection and…
2022 American Transplant Congress
Antibody and Cellular Immunity After Primary mRNA Vaccination in Adolescents with Stable Liver or Liver-Inclusive Intestine Allografts
G. Mazariegos¹, C. Ashokkumar², K. Soltys², M. Michaels², G. Bond², A. Khanna², M. Ningappa², P. Morgan², R. Sindhi²
¹UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ²Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA
*Purpose: Transplant recipients experience lower seroconversion rates after COVID-19 vaccination compared with healthy adults and have been prioritized to receive booster doses. To assess pre-…