Articles tagged "COVID-19"

2022 American Transplant Congress
SARS-CoV-2 Infection is Associated with Greater Neutralizing Antibody Response Compared to Three Doses of Mrna-1273 Vaccine in Solid Organ Transplant Recipients
V. H. Ferreira, V. Hall, T. M. Marinelli, M. Ierullo, V. Kulasingam, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: Prior studies suggest that two doses of mRNA vaccine in SOTR may result in lower antibody and T-cell responses relative to levels seen following…
2022 American Transplant Congress
Clinical Features and Outcomes of Hospitalized Solid Organ Transplant and Hematopoietic Stem Cell Recipients with Sars-CoV-2 Infection in the Midwestern United States: A Multi-Center Retrospective Cohort Study
S. Tanna¹, D. Florescu², A. Majeed³, J. Banzon³, S. Waller⁴, A. Eid⁴, N. Barros Baertl⁵, D. Friedman⁶, K. Mullane⁷, M. Ison⁸
¹Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, ²University of Nebraska Medical Center, Omaha, NE, ³Cleveland Clinic, Cleveland, OH, ⁴University of Kansas Medical Center, Overland Park, KS, ⁵Infectious Diseases, Indiana University, Indianapolis, IN, ⁶Infectious Diseases, University of Chicago, Chicago, IL, ⁷University of Chicago, Chicago, IL, ⁸Northwestern University Comprehensive Transplant Center, Chicago, IL
*Purpose: Immunocompromised hosts are at risk for severe complications or death from SARS-CoV-2 infection. Few studies describe the clinical features, outcomes and treatment strategies in…
2022 American Transplant Congress
Early Clinical Experience With Alvr109, A Partially Hla-matched Sars-cov-2 Specific T-cell Therapy, In Immunocompromised Patients With Covid-19
G. Haidar¹, J. Jacobs², K. Hughes², K. McCormick², A. Naqvi², M. Agha², T. Bogdanovich², B. Johnson², J. Kozar², E. Lendermon², C. Marino², A. Raptis², F. Silveira², W. Marshall³, M. Miller³, E. Atillasoy³, J. Mellors²
¹University of Pittsburgh, Pittsburgh, PA, ²UPitt, Pittsburgh, PA, ³Allovir, Waltham, MA
*Purpose: Therapies for COVID-19 in immunocompromised (IC) patients (pts), including transplant (tx) pts, are limited. We describe our experience with ALVR109, an allogeneic, partially HLA-matched…
2022 American Transplant Congress
Outcomes of SARS-CoV-2 Infection in Unvaccinated Compared with One or Two Dose Vaccinated Solid Organ Transplant Recipients: A Multicenter, Matched Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Ramesh Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, J. Matelski², A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³Department of Medicine, UMontreal, Montreal, QC, Canada, ⁴Kidney Transplant Program, St. Michael's Hospital, Toronto, ON, Canada, ⁵Transplantation Unit, Renal division, Laval University, Quebec, QC, Canada, ⁶Division of Transplant Medicine, University of Calgary, Calgary, AB, Canada, ⁷University Health Center of Saskatchewan, Saskatoon, SK, Canada, ⁸Hôpital Maisonneuve-Rosemont Research Institute, Montreal, QC, Canada, ⁹McGill University, Montreal, QC, Canada, ¹⁰Stollery Children's Hospital, Edmonton, AB, Canada
*Purpose: It is unknown if vaccine breakthrough COVID-19 infections are milder or as severe as infections in unvaccinated solid organ transplant (SOT) recipients.*Methods: We performed…
2022 American Transplant Congress
One-Year Outcomes in Kidney Transplant Recipients with Acute Kidney Injury and COVID-19
P. Shrivastava¹, R. M. Hofmann², S. P. Norman³, D. Granger⁴, N. Khoury¹, R. Prashar¹, C. Crombez⁵, A. Patel¹, S. Nagai⁶, M. Lu⁷, M. Samaniego¹
¹Department of Medicine, Henry Ford Health System, Detroit, MI, ²Renal Associates of West Michigan, Grand Rapids, MI, ³Department of Medicine, University of Michigan, Ann Arbor, MI, ⁴Department of Surgery, Ascension St. John Hospital,, Detroit, MI, ⁵Department of Transplant Surgery, Henry Ford Health System, Detroit, MI, ⁶Department of Surgery, Henry Ford Health System, Detroit, MI, ⁷Department of Public Health Sciences, Henry Ford Health System, Detroit, MI
*Purpose: Acute kidney injury (AKI) occurs in more than half of kidney transplant recipients (KTRs) with COVID-19. The longitudinal trajectory of kidney function is unclear.…
2022 American Transplant Congress
Sars-cov2 Antibody Kinetics and Durability Three and Six Months After Two-Doses of MRNA Vaccination in Liver Transplant Recipients
A. Chang¹, A. T. Strauss¹, T. P. Chiang¹, A. Jennifer¹, H. Nicole¹, L. Zeiser¹, B. Boyarsky¹, R. Avery¹, A. Tobian¹, M. Levan¹, D. Warren¹, A. Massie¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²University of Wisconsin School of Medicine, Madison, WI
*Purpose: nti-spike antibody response to SARS-CoV-2 vaccination is diminished in LT recipients compared to the general population so understanding durability for those that do respond…
2022 American Transplant Congress
Impaired Cellular Immunity and Elevated Myeloid Derived Suppressor Cells in Kidney Transplant Recipients with Impaired Antibody Response to Covid-19 Vaccination
B. Nibhanupudy¹, K. Mcdonald¹, M. Angelis¹, L. T. Chin¹, P. Wai¹, R. Metzger¹, C. Ashokkumar², R. Sindhi²
¹AdventHealth Transplant Institute, Orlando, FL, ²Plexision, Inc, Pittsburgh, PA
*Purpose: To evaluate post-vaccination cellular and antibody (Ab) immunity after COVID-19 vaccination in single blood samples from 17 kidney transplant (KT) recipients who had received…
2022 American Transplant Congress
Impact of ATG Dose Reduction on Kidney Transplant Outcomes During the Covid-19 Pandemic
P. A. Than¹, F. De Leon¹, K. Jen², N. Goussous¹, R. V. Perez¹, A. X. Wang³
¹Transplant Surgery, UC Davis, Sacramento, CA, ²Pathology, UC Davis, Sacramento, CA, ³Transplant Nephrology, UC Davis, Sacramento, CA
*Purpose: During the COVID-19 pandemic, many transplant centers modified induction immunosuppression regimens. Beginning December 2020, our center reduced anti-thymocyte globulin (ATG) protocol dosing by up…
2022 American Transplant Congress
Effect of Covid-19 Diagnosis on Organ Donation and Transplantation
L. Baetje¹, A. Cheng¹, S. Sander², L. Markham², M. Ott², J. Finn², A. Wee³, K. Dyer⁴, A. Atluri¹, D. Jahandar¹, M. Moncure⁴
¹University of Missouri - Kansas City School of Medicine, Kansas City, MO, ²Midwest Transplant Network, Westwood, KS, ³Transplantation Center, Cleveland Clinic, Cleveland, OH, ⁴University Health Kansas City, Kansas City, MO
*Purpose: The coronavirus disease 2019 (COVID-19) pandemic has challenged many aspects of healthcare, including organ donation and transplantation. The purpose of this study is to…
2022 American Transplant Congress
Impact of COVID on Transplant Professionalism
A. Luxon¹, D. Brennan², F. Latif³, M. Flattery⁴, S. Aryal⁵
¹CareDx, South San Francisco, CA, ²Johns Hopkins Medical Institute, Baltimore, MD, ³Columbia University, New York, NY, ⁴Virginia Commonwealth University, Richmond, VA, ⁵Inova Fairfax Hospital, Falls Church, VA
*Purpose: Although, much has been written about COVID risk and immunization efficacy in transplant recipients, there is little data on the impact of COVID on…