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Articles tagged "COVID-19"

  • 2022 American Transplant Congress

    COVID-19 Vaccination Induces a Poor Interleukin-21 Memory T-cell Response in Kidney Transplant Recipients

    S. R. Malahe1, Y. den Hartog1, R. de Kuiper1, D. Reijerkerk1, D. Geers2, C. H. GeurtsvanKessel2, M. M. Kho1, R. D. de Vries2, M. E. Reinders1, C. C. Baan1

    1Internal Medicine, Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands, 2Viroscience, Erasmus MC, Rotterdam, Netherlands

    *Purpose: COVID-19-related morbidity and mortality is high among kidney patients. Several studies recently suggested low humoral and cellular immune responses after two doses of mRNA-1273…
  • 2022 American Transplant Congress

    Kinetics and Durability of a Third Dose of Sars-cov-2 Vaccination Among Solid Organ Transplant Recipients

    T. P. Chiang, J. Alejo, J. Mitchell, A. Abedon, L. Zeizer, J. Kim, L. Thomas, D. Segev, W. Werbel, A. Massie

    Johns Hopkins University, Baltimore, MD

    *Purpose: Understanding the dynamics of antibody response to a third dose (D3) of anti-SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) is important to inform…
  • 2022 American Transplant Congress

    Covid-19 Vaccination Response In Tacrolimus Treated Kidney Transplant Recipients With And Without Mycophenolate Mofetil: Follow-up Of A Randomized Controlled Trial

    Z. Al Fatly1, M. G. Betjes1, A. L. Messchendorp2, J. S. Sanders2, M. E. Reinders1, M. M. Kho1, A. E. de Weerd1

    1Department of Internal Medicine, Erasmus MC Transplant Institute University Medical Center, Rotterdam, Netherlands, 2Department of Internal Medicine, Groningen Medical Center, Groningen, Netherlands

    *Purpose: To investigate the effect of mycophenolate mofetil (MMF) on SARS-CoV-2 vaccination response in kidney transplant recipients using the standard immunosuppressive regimen of tacrolimus (TAC)…
  • 2022 American Transplant Congress

    Higher Immunogenicity of a Third Heterologous Dose with BNT262b2 Mensanger RNA Vaccine Compared to a Homologous Dose in Kidney Transplant Recipients Fully Vaccinated with Inactivated Whole-Virion CoronaVac Vaccine

    L. V. Pouzo1, M. Nakamura1, L. A. Viana2, E. Lucena1, M. Jesus1, G. Bittencourt Pereira Lima1, J. Medina1, H. Tedesco1, M. Cristelli1

    1Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil, 2Nephrology, Hospital do rim, Sao Paulo, Brazil

    *Purpose: This study aims to compare the immunogenicity of a third dose of the heterologous BNT262b2 mRNA vaccine versus the homologous inactivated whole-virion CoronaVac vaccine…
  • 2022 American Transplant Congress

    Humoral and Cellular Immune Response to a Third Dose Of SARS-CoV-2 Vaccine in Kidney Transplant Recipients on Belatacept

    J. Mitchell1, J. Alejo1, T. P. Chiang1, J. N. Blankson1, A. H. Karaba1, B. Woldemeskel1, C. Garliss1, A. Chang1, A. Abedon1, R. K. Avery1, A. Tobian1, A. B. Massie1, J. Garonzik-Wang2, D. L. Segev1, W. Werbel1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin, Madison, WI

    *Purpose: Kidney transplant recipients taking belatacept (KTR-B) have poor immune response to two-dose SARS-CoV-2 vaccination. We sought to characterize the impact of an additional vaccine…
  • 2022 American Transplant Congress

    Impact of Immunosuppression on T-cell Responses After mRNA-Based Sars-CoV-2 Vaccination

    E. Wong1, N. L. Bert2, H. K. Sran1, A. Lim1, M. D'Costa1, K. Akalya2, S. Hang2, A. Bertoletti2, A. Vathsala1

    1National University Centre for Organ Transplantation, National University Hospital, Singapore, Singapore, 2Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore

    *Purpose: Administration of mRNA-based SARS-CoV-2 vaccines confers protection from SARS-CoV-2 infection and reduces its severity in the general population. It has been suggested that mounting…
  • 2022 American Transplant Congress

    CoVID-19 Vaccine Efficacy in Heart Transplant Recipients, a Single Center Experience

    M. Yu1, S. B. Sharmin2, C. Joyce3, Z. Pieters1, S. DeSirkar1, M. Thomas1, S. Kim1, E. Bruno1, M. Liebo1, A. Heroux4, N. Clark1, G. Reid1, S. Uprichard2

    1Loyola University Medical Center, Maywood, IL, 2Microbiology and Immunology, Loyola University Chicago, Chicago, IL, 3Department of Public Health Sciences, Loyola University Chicago, Chicago, IL, 4Loyola Univ Medical Ctr, Maywood, IL

    *Purpose: Transplant recipients have worse CoVID-19 survival compared to the general population, and thus are recommended to be vaccinated and boosted. Determinants of vaccination efficacy…
  • 2022 American Transplant Congress

    Impact of COVID-19 on Increased Mortality in Liver Transplant Recipients in United States

    K. Okumura, A. Dhand, R. Misawa, H. Sogawa, R. Bodin, D. C. Wolf, S. Nishida

    Westchester Medical Center / New York Medical College, Valhalla, NY

    *Purpose: COVID-19 pandemic has had a significant impact on access to routine healthcare in both hospitalized and out-patient settings. This impact was also noted in…
  • 2022 American Transplant Congress

    T and B Cell Response to 3 Dose Covid Vaccine Series for Kidney Transplant Patients on Belatacept

    J. Christensen1, I. Yakubu2, D. Kumar1, D. Cornett3, M. A. Miller3, M. Altrich3, L. Flebbe-Rehwaldt3, R. Thompson1, G. Gupta1

    1Internal Medicine, Transplant Nephrology, VCUHealth, Richmond, VA, 2Pharmacy, VCUHealth, Richmond, VA, 3Eurofins Viracor, Lee's Summit, MO

    *Purpose: Data shows COVID vaccine response after 2 doses in patients on Belatacept immunosuppression (IS) is low, with reported rates of seroconversion (as measured by…
  • 2022 American Transplant Congress

    Comparison of Outcomes and Management of COVID Infection Among Kidney Transplant Recipients Between Pre-Vaccination Rollout Era and Post-Vaccination Rollout Era

    G. Uehara1, K. Soliman2, V. Rao2, M. Casey2, D. Taber3, M. Posadas Salas2

    1Medical University of South Carolina, Charleston, SC, 2Nephrology, Medical University of South Carolina, Charleston, SC, 3Transplant Surgery, Medical University of South Carolina, Charleston, SC

    *Purpose: The COVID pandemic has posed a significant challenge among kidney transplant recipients (KTR) due to their immunocompromised states. The effects of COVID vaccination on…
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