2015 American Transplant Congress
Selective CD28 Blockade With or Without CD40-CD154 Blockade Promotes Cardiac Allograft Protection in Non-Human Primates
1Surgery, University of Maryland School of Medicine, Baltimore, MD; 2INSERM, U643, Nants, France.
Aim: Selective targeting CD28:B7 costimulation without interfering with CTLA-4-dependent immune regulation is theoretically an attractive approach to modulate pathogenic T cell-dependent immunity. We previously reported…2015 American Transplant Congress
Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival
Surgery, Emory Transplant Center, Atlanta, GA.
[Background] Preformed donor specific antibody (DSA) due to prior sensitization affects a significant population of transplant patients, portending a poorer prognosis in short- and long-term…2015 American Transplant Congress
CTLA4Ig Administered During T-Cell Priming Negates de novo Alloantibody Responses and Modulates Recall Antibody Production
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Arcadia, CA.
Background CTLA4Ig (Belatacept) is a novel anti-rejection therapy aimed at costimulatory blockade. Clinical data suggest that post-transplant alloantibody formation is also reduced in patients treated…
- « Previous Page
- 1
- …
- 28
- 29
- 30