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Articles tagged "Co-stimulation"

  • 2015 American Transplant Congress

    Tissue Engineering Human Kidneys for Costimulation Blockade

    L. Brasile,1 N. Henry,1 A. Meyer,1 B. Stubenitsky.2

    1BREONICS, Inc., Watervliet, NY; 2Surgery, University of Utrecht, Utrecht, Netherlands.

    Methods for preserving organs have employed hypothermic conditions. At these temperatures metabolism is 4% of normal. Tissue engineering of organs cannot be done without significant…
  • 2015 American Transplant Congress

    Defining the Role of CD57+CD4 T Cells in Belatacept-Resistant Rejection

    J. Espinosa,1,2 L. Stempora,1,2 R. Townsend,3 A. Kirk.1,2

    1Duke University, Durham, NC; 2Emory University, Atlanta, GA; 3Bristol-Myers Squibb, Princeton, NJ.

    Purpose: We have shown that CD57+PD1- CD4 T cells are present in higher numbers in the peripheral blood and allograft biopsies of patients who experienced…
  • 2015 American Transplant Congress

    Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization

    N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    [bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…
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