ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Co-stimulation"

  • 2015 American Transplant Congress

    Selective CD28 Blockade With or Without CD40-CD154 Blockade Promotes Cardiac Allograft Protection in Non-Human Primates

    T. Zhang,1 A. Kronfli,1 B. Gheorghe,1 L. Burdorf,1 E. Rybak,1 D. Parsell,1 D. Harris,1 E. Sievert,1 S. Dahi,1 N. Kubicki,1 J. Whoddal,1 M. Uluer,1 X. Cheng,1 E. Schwartz,1 K. Quinn,1 B. Vanhove,2 A. Azimzadeh,1 R. Pierson III.1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD; 2INSERM, U643, Nants, France.

    Aim: Selective targeting CD28:B7 costimulation without interfering with CTLA-4-dependent immune regulation is theoretically an attractive approach to modulate pathogenic T cell-dependent immunity. We previously reported…
  • 2015 American Transplant Congress

    Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival

    J. Kwun, C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, S. Knechtle.

    Surgery, Emory Transplant Center, Atlanta, GA.

    [Background] Preformed donor specific antibody (DSA) due to prior sensitization affects a significant population of transplant patients, portending a poorer prognosis in short- and long-term…
  • 2015 American Transplant Congress

    CTLA4Ig Administered During T-Cell Priming Negates de novo Alloantibody Responses and Modulates Recall Antibody Production

    G. Wu, I. Kim, N.-N. Chai, S. Jordan, A. Klein.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Arcadia, CA.

    Background CTLA4Ig (Belatacept) is a novel anti-rejection therapy aimed at costimulatory blockade. Clinical data suggest that post-transplant alloantibody formation is also reduced in patients treated…
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