Articles tagged "Co-stimulation"

2015 American Transplant Congress
VLA-4 Blockade Inhibits Endogenous Memory CD8 T Cell-Mediated Rejection of Cardiac Allografts
S. Iida,¹ C. Su,¹ T. Abe,¹ K. Tanabe,² R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Endogenous memory CD8 T cells infiltrate cardiac allografts within 24 hours of reperfusion and are activated to proliferate and produce IFN-γ in response to donor…
2015 American Transplant Congress
Bridging Therapy With Belatacept in High MELD Liver Transplant Recipients
T. Sparkes,¹ B. Masters,¹ S. Hanish,² D. Potosky,² W. Hutson,² J. LaMattina,² R. Barth.²
¹University of Maryland Medical Center, Baltimore; ²University of Maryland School of Medicine, Baltimore.
Background: Poor outcomes of high-MELD liver transplant recipients are driven by multisystem organ dysfunction. Renal failure post-transplant has been associated with mortality of greater than…
2015 American Transplant Congress
Overexpression of 2B4 Inhibits the Expansion and Function of Donor-Reactive CD8+ T Cells in Selective Lymphoid Compartments
S. Laurie, D. Liu, M. Ford.
Department of Surgery, Emory University, Atlanta, GA.
2B4 is an immunoglobulin superfamily member expressed constitutively on NK cells, and inducibly on some CD8+ T cells. We recently showed in a murine skin…