ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Co-stimulation"

  • 2015 American Transplant Congress

    Costimulation Blockade Prevents Rejection of Vascularized Composite Allografts

    B. Oh,1 G. Furtmüller,1 M. Fryer,1 J. Grahammer,2 S. Schneeberger,2 D. Cooney,1 W. Lee,1 G. Brandacher.1

    1Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; 2Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.

    [Background] Vascularized composite allotransplantation (VCA) is an emerging new era in transplant medicine and has become a valid therapeutic option after devastating tissue loss. The…
  • 2015 American Transplant Congress

    Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice

    M. Sabet-Baktach,1 E. Eggenhofer,1 P. Renner,1 M. Lantow,1 H. Schlitt,1 E. Geissler,1 A. Kroemer.1,2

    1Department of Surgery, University Hospital Regensburg, Regensburg, Germany; 2Georgetown Transplant Institute, Georgetown Transplant Institute, Washington, DC.

    The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…
  • 2015 American Transplant Congress

    Tissue Engineering Human Kidneys for Costimulation Blockade

    L. Brasile,1 N. Henry,1 A. Meyer,1 B. Stubenitsky.2

    1BREONICS, Inc., Watervliet, NY; 2Surgery, University of Utrecht, Utrecht, Netherlands.

    Methods for preserving organs have employed hypothermic conditions. At these temperatures metabolism is 4% of normal. Tissue engineering of organs cannot be done without significant…
  • 2015 American Transplant Congress

    Defining the Role of CD57+CD4 T Cells in Belatacept-Resistant Rejection

    J. Espinosa,1,2 L. Stempora,1,2 R. Townsend,3 A. Kirk.1,2

    1Duke University, Durham, NC; 2Emory University, Atlanta, GA; 3Bristol-Myers Squibb, Princeton, NJ.

    Purpose: We have shown that CD57+PD1- CD4 T cells are present in higher numbers in the peripheral blood and allograft biopsies of patients who experienced…
  • 2015 American Transplant Congress

    Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization

    N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    [bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…
  • 2015 American Transplant Congress

    A Novel, Blocking Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B-Cell Depletion Or Thromboembolic Events

    J. Rush,1 G. Wieczorek,1 M. Audet,2 M. Schneider,1 P. Espie,3 L. Roth,1 C. Heusser,1 C. Bruns,1 D. Patel,1 F. Cordoba.1

    1Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland; 2Hôpital de Hautepierre, Strasbourg, France; 3Drug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, Basel, Switzerland.

    Background. CD40-CD154 pathway blockade prolongs renal allograft survival in non-human primates (NHPs). However, antibodies targeting CD154 were associated with an increased incidence of thromboembolic complications…
  • 2015 American Transplant Congress

    In Vitro Evidence That CTLA4Ig Attenuates Recall Alloantibody Responses

    I. Kim,1 G. Wu,1 N.-N. Chai,1 S. Jordan,2 A. Klein.1

    1Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; 2Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: CTLA4Ig is an agonist that blocks CD28-B7 costimulation, downregulating T cell immunity, but also appears to negate T cell-dependent B cell activation, thus inhibiting…
  • 2015 American Transplant Congress

    Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells

    M. Uchiyama,1,2,3 E. Yin,3,4 X. Jin,3,5 T. Shimokawa,1 H. Yagita,2 M. Niimi.3

    1Cardiovascular Surgery, Teikyo University, Tokyo, Japan; 2Immunology, Juntendo University Hospital, Tokyo, Japan; 3Surgery, Teikyo University, Tokyo, Japan; 4Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; 5Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.

    Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
  • 2015 American Transplant Congress

    Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation

    C. Burghuber,1,2 J. Kwun,1 E. Page,1 A. Gibby,1 F. Leopardi,3 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1,3

    1Emory Translant Center, Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…
  • 2015 American Transplant Congress

    Blocking CD4 T Cell Helper Functions Improves Efficacy of ATG Treatment in Sensitized Transplant Recipients

    K. Ayasoufi, X. Wang, H. Yu, V. Gorbacheva, F. Ran, R. Fairchild, A. Valujskikh.

    Immunology, Cleveland Clinic, Cleveland, OH.

    Antibody mediated lymphocyte depletion is used in clinical transplantation to improve graft function. While the presence of donor-reactive memory T cells is the primary rationale…
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