ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Co-stimulation"

  • 2015 American Transplant Congress

    Bridging Therapy With Belatacept in High MELD Liver Transplant Recipients

    T. Sparkes,1 B. Masters,1 S. Hanish,2 D. Potosky,2 W. Hutson,2 J. LaMattina,2 R. Barth.2

    1University of Maryland Medical Center, Baltimore; 2University of Maryland School of Medicine, Baltimore.

    Background: Poor outcomes of high-MELD liver transplant recipients are driven by multisystem organ dysfunction. Renal failure post-transplant has been associated with mortality of greater than…
  • 2015 American Transplant Congress

    Overexpression of 2B4 Inhibits the Expansion and Function of Donor-Reactive CD8+ T Cells in Selective Lymphoid Compartments

    S. Laurie, D. Liu, M. Ford.

    Department of Surgery, Emory University, Atlanta, GA.

    2B4 is an immunoglobulin superfamily member expressed constitutively on NK cells, and inducibly on some CD8+ T cells. We recently showed in a murine skin…
  • 2015 American Transplant Congress

    CD4 T Cell Mediated Help Is Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage

    H. Tsuda,1,4 T. Tanaka,2,4 N. Kohei,3,4 D. Kish,4 W. Baldwin,4 A. Valujskikh,4 R. Fairchild.4

    1Advanced Technology for Transplantation, Osaka Univ., Suita, Japan; 2Urology, Sapporo Medical Univ., Sapporo, Japan; 3Urology, Tokyo Women's Medical Univ., Tokyo, Japan; 4Immunology, Cleveland Clinic, Cleveland, OH.

    Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
  • 2015 American Transplant Congress

    CD27low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8+ T Cell Responses Through Controlling Graft-Derived Donor DCs

    A. Kroemer,1,2 M. Lantow,1 E. Eggenhofer,1 M. Sabet-Baktach,1 P. Renner,1 H. Schlitt,1 E. Geissler.1

    1Department of Surgery, University Hospital Regensburg, Regensburg, Germany; 2Georgetown Transplant Institute, Washington, DC.

    The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…
  • 2015 American Transplant Congress

    The Immunosuppressive Effect of CTLA4Ig Monotherapy Depends On the Presence of Tregs Only at Suboptimally Low Doses

    C. Schwarz,1 L. Unger,1 B. Mahr,1 K. Aumayr,2 N. Pilat,1 K. Hock,1 A. Farkas,1 I. Kristo,1 T. Wekerle.1

    1Dept. of Surgery, Medical University of Vienna, Vienna, Austria; 2Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.

    Background: CTLA4Ig/belatacept has been recently approved for immunosuppression after renal transplantation. Concerns persist, however, that a paradoxical dose-response relationship might exist for CTLA4Ig in which…
  • 2015 American Transplant Congress

    Deceased Donor Kidney Transplantation Without Calcineurin Inhibitors or Steroids

    A. Kirk,1,2 A. Guasch,1 S. Mead,1 A. Ghali,1 A. Mehta,1 H. Gebel,1 R. Bray,1 C. Larsen,1 T. Pearson.1

    1Transplant Center, Emory University, Atlanta, GA; 2Surgery, Duke University, Durham, NC.

    Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative delivered by monthly intravenous infusion, but…
  • 2015 American Transplant Congress

    Interleukin-1 Receptor Signaling by Graft Stromal Cells Regulates Donor-Reactive CD8 T Cell Responses to Cardiac Allografts

    S. Iida,1 D. Kish,1 R. Abe,2 K. Tanabe,3 W. Baldwin,1 R. Fairchild.1

    1Immunology, Cleveland Clinic, Cleveland, OH; 2Immunology, Science University of Tokyo, Chiba, Japan; 3Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Allograft reperfusion induces inflammation that directs the infiltration of memory T cells into the allograft and their activation to express functions mediating graft injury. The…
  • 2015 American Transplant Congress

    Lower Frequency of Regulatory T-Cells After Conversion from CNIs or mTORi to Belatacept in a Prospective Matched Controlled Study in Renal Allograft Recipients

    M. Dürr, J. Liu, K. Budde.

    Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.

    Objective: Regulatory T-cells (Tregs) are considered to play a crucial role in maintaining control of immune response following renal transplantation (Tx). So far, only limited…
  • 2015 American Transplant Congress

    Repurposing Jak/STAT Signaling Inhibition to Enhance Costimulation Blockade and Promote Transplant Acceptance

    G. Raimondi, S. Khalifian, D. Miller, B. Oh, G. Furtmueller, M. Fryer, W. Lee, G. Brandacher.

    Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore.

    PURPOSE: Transplant tolerance induction through conventional costimulation blockade (CoB) remains an elusive goal. Recent evidence suggests that inflammatory cytokines contribute to the activation of alloreactive…
  • 2015 American Transplant Congress

    Selective Blockade of the CD28/B7/CTLA4 Pathway With Monovalent Anti-CD28 Antibodies Versus Targeting of B7 With CTLA4-Ig, in Non-Human Primate Kidney Allograft

    S. Ville,1 N. Poirier,1,2 B. Vanhove,1,2 G. Blancho.1

    1INSERM, UMR1064, ITUN, Nantes, France; 2Effimune SAS, Nantes, France.

    B7 molecules on antigen-presenting cells interact with CD28 and CTLA4 on T lymphocytes to control TCR-mediated signals. Whereas it is highly efficient to block T…
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