2017 American Transplant Congress
Dual Targeting of Costimulation and Proteasome to Desensitize and Prolong Graft Survival of Sensitized Nonhuman Primates.
[Background] Pre-formed donor-specific anti-HLA antibodies (DSA) from prior transplantation, transfusion, or pregnancy affects a significant portion (35%) of patients awaiting a kidney transplant. Highly sensitized…2017 American Transplant Congress
FcγRIIB-Mediated Coinhibition Attenuates Donor-Reactive CD8+ T Cell Responses.
Emory Transplant Center, Emory University, Atlanta, GA
Memory T cells can be a formidable barrier to long-term, rejection-free allograft survival, particularly in the setting of costimulation blockade. Ongoing work in the field…2017 American Transplant Congress
Immunoregulatory Roles of CD137 Signaling in Graft-versus-Host Disease.
CD137 functions mainly as a costimulatory molecule for T cell activation. However, its functions have been found in a variety of other immune and nonimmune…2017 American Transplant Congress
mTOR Inhibition Diminishes Peripheral Blood CD8+CD28–CD38hi Effector/Memory T Cells and Facilitates Resolution of Belatacept-Refractory Kidney Rejection.
Belatacept, a CD28-CD80/86 blocker, was approved by the FDA to provide immunosuppression without nephrotoxicity or cardiovascular and metabolic adverse effects. As part of our multi-center…2017 American Transplant Congress
CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…2017 American Transplant Congress
Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated with Belatacept.
Emory Transplant Center, Atlanta, GA
Introduction: Focal segmental glomerulosclerosis (FSGS) is a cause of end-stage renal failure that frequently recurs following renal transplant, often leading to allograft loss. A recently…2017 American Transplant Congress
Potential Mechanism Involving Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Composite Allotransplantation Under Combined Costimulation Blockade.
Background: Role of Regulatory T cells in vascularized composite allotransplantation (VCA) remains to be elucidated. In this study, we investigate potential mechanism involved in Tregs…2017 American Transplant Congress
CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplantation has met limited success. T cell-mediated damage remains a critical problem. Our group has…2017 American Transplant Congress
Alemtuzumab Induction and Belatacept Maintenance in Marginal Pathology Renal Allografts.
University of Maryland, Baltimore
Background: The potential for improved outcomes with CNI avoidance may be important for kidneys with an increased likelihood of impaired graft function. We performed a…2017 American Transplant Congress
High CTLA-4 Expression and Diminished FOXO3 Expression Underlie Differential CD28 Signaling on Human Memory Th17 Cells.
Pathogen primed memory T cells can cross-react with allogeneic antigen and mediate graft rejection, a process termed allogeneic heterologous immunity. Th17 cells are pro-inflammatory CD4+…
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