ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Co-stimulation"

  • 2022 American Transplant Congress

    Tolerant B Cells Suppress Memory B Cells in a Donor Specific Manner in CoB Mediated Transplantation Tolerance

    S. Durgam1, D. Yin1, M. Alegre2, A. Chong1

    1Surgery, section of transplant immunology, University of Chicago, Chicago, IL, 2Medicine, section of rheumatology, University of Chicago, Chicago, IL

    *Purpose: We previously reported that B cells in recipients made tolerant to fully mismatched heart allografts by anti-CD154+donor spleen cells (CoB) become dysfunctional in their…
  • 2022 American Transplant Congress

    Donor-Specificb Cell Dysfunction and Suppressive Ability Are Differentially Induced in Cob-Mediated Transplantation Tolerance

    S. Durgam1, D. Yin1, M. Alegre2, A. Chong1

    1Surgery, section of transplant immunology, University of Chicago, Chicago, IL, 2Medicine, section of rheumatology, University of Chicago, Chicago, IL

    *Purpose: B cells in mice tolerized to fully mismatched heart allografts with anti-CD154+donor spleen cells (CoB) are intrinsically dysfunctional and unable to differentiate into germinal…
  • 2022 American Transplant Congress

    Belatacept Augments Mixed Chimerism in a Novel Nonhuman Primate Kidney Transplant Tolerance Induction Protocol

    S. C. Kim, C. J. Little, J. H. Fechner, P. J. Chlebeck, J. Post, A. D'Alessandro, D. B. Kaufman

    University of Wisconsin, Madison, WI

    *Purpose: A novel protocol of antilymphocyte globulin (ATG), tomotherapy-based total lymphoid irradiation (TomoTLI), and adoptive cellular transfer was developed in a preclinical model of MHC-mismatched…
  • 2022 American Transplant Congress

    Five-Year Follow-Up from a Prospective, Randomized Trial of Belatacept-Based, CNI Free/Early Steroid Withdrawal Regimens

    H. Hames1, A. R. Shields1, E. Yanqui1, A. Christianson1, J. Kremer2, A. Govil1, E. S. Woodle1, R. R. Alloway1

    1University of Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH

    *Purpose: A prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based, calcineurin inhibitor-free (CNI), early corticosteroid withdrawal (ESW) regimens with a tacrolimus (TAC)-based ESW…
  • 2022 American Transplant Congress

    Validation of the iBox Surrogate End Point in CNI Free, Belatacept Treated Patients (BENEFIT & BENEFIT-EXT)

    G. Divard1, O. Aubert1, M. Raynaud1, F. Vincenti2, L. Rostaing3, A. Durbach4, C. Legendre1, R. Vadanici5, A. Loupy1, -. BENEFIT & BENEFIT-EXT Investigators6

    1Paris Transplant Group, INSERM, Paris, France, 2UCSF, San Francisco, CA, 3Grenoble, Grenoble, France, 4APHP, Paris, France, 5BMS, Rueil Malmaison, France, 6BMS, New York, NY

    *Purpose: The iBox is a prognostication system for long-term kidney allograft survival, developed with mostly patients under a CNI based immunosuppression. Patients treated with a…
  • 2022 American Transplant Congress

    Long-Term Outcomes After Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant: A Matched Cohort Study

    G. Divard, C. Debiais, C. Legendre, O. Aubert, C. Lefaucheur, A. Loupy

    Paris Transplant Group, INSERM, Paris, France

    *Purpose: Conversion to belatacept after transplant seems to be safe. However, no studies have reported the long-term efficacy and safety outcomes after conversion to belatacept…
  • 2022 American Transplant Congress

    CD8+ T Cells Differentiate into a CD43-expressing Effector Population After Transplantation

    G. Cohen, M. A. Kallarakal, S. M. Krummey

    Department of Pathology, Johns Hopkins University, Baltimore, MD

    *Purpose: Despite a significantly reduced toxicity profile and improved long-term graft function versus calcineurin inhibitors, widespread adaptation of belatacept (CTLA-4 Ig) has been limited due…
  • 2022 American Transplant Congress

    Conversion to Belatacept for Calcineurin Inhibitor Toxicities

    S. S. Patel, P. Jadav, M. Sekulic, S. Kudose, I. Batal, S. Mohan, R. Crew

    Columbia University Medical Center, New York, NY

    *Purpose: Calcineurin inhibitors (CNIs) have improved renal transplant (RTx) outcomes but are associated with significant toxicities. Belatacept provides better long-term outcomes than cyclosporine, has less…
  • 2022 American Transplant Congress

    p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts

    H. Tsuda1, A. Valujskikh2, R. Fairchild3

    1Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, 2The Cleveland Clinic Fdn, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
  • 2022 American Transplant Congress

    Desensitization Using Costimulatory Blockade and Bortezomib to Prevent DSA Formation and Rejection in Reconstructive Transplantation

    B. Oh, F. Messner, Y. Guo, G. Brandacher

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Sensitization in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection constitute some of the greatest risk factors for allograft rejection and long-term graft…
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