ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Co-stimulation"

  • 2018 American Transplant Congress

    Enrichment of Endogenous Donor-Reactive Tregs in the Spleen and Graft during Transplantation Tolerance is the Result of Treg Proliferation and Conversion from Tconv

    J. Young, D. Yin, M-.L. Alegre, A. Chong.

    Surgery and Medicine, University of Chicago, Chicago, IL.

    Foxp3+ regulatory T cells (Tregs) are critical mediators of immune tolerance and are absolutely required for allograft tolerance in animal models. In addition, clinical trials…
  • 2018 American Transplant Congress

    The Infusion with a Difference: Patient Experiences with Belatacept

    H. Murad, D. Malhotra, E. Cohen, W. Asch.

    Yale University, New Haven, CT.

    Introduction: The results of the BENEFIT trial led to the FDA approval of the novel anti-rejection agent belatacept (bela) in 2011. In addition to its…
  • 2018 American Transplant Congress

    Inhibition of IL-1R1 Signaling Delays Costimulation Blockade–Resistant Allograft Rejection by Preventing CD8 TEM Expansion

    Y. Liu, Y. Dong, D. Mathews, A. Ghosh, A. Adams.

    Department of Surgery, Emory University, Atlanta, GA.

    The clinical utilization of Costimulaiton Blockade (CoB) led to improved long-term patient outcomes, but wider adoption of is hampered by increased rates of acute cellular…
  • 2018 American Transplant Congress

    Circulating T Follicular Helper Cells Expand Following Transplantation and Exhibit a CD44hi Phenotype That Correlates with Peak Germinal Center Alloreactivity

    G. La Muraglia II, M. Wagener, M. Ford, R. Badell.

    Emory Transplant Center, Atlanta.

    It is increasingly well-recognized that donor-specific antibodies (DSA) play a significant role in the development of chronic rejection and fibrosis that contribute to late renal…
  • 2017 American Transplant Congress

    TIM-4 Identifies Pro-Inflammatory B Effector Cells That Are Potent Drivers of Alloimmunity and Allograft Rejection Through Expression of Both IFN-γ and IL-17.

    Q. Ding, K. Mohib, D. Rothstein.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh

    B cells can either augment or inhibit immune responses due to the presence both regulatory (Bregs) and effector (Beff) B cells expressing anti- or pro-…
  • 2017 American Transplant Congress

    The Treg/Th17 Axis: A Dynamic Balance Regulated by Stromal Laminins.

    T. Simon, J. Bromberg.

    University of Maryland, Baltimore

    Background: Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively…
  • 2017 American Transplant Congress

    A Regulatory T Cell (Treg)-Intrinsic Role for p27kip1 in Acquired Transplant Tolerance.

    P. Morawski, L. Wang, X. Yang, Y. Chen, W. Hancock, A. Wells.

    Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA

    We previously found that the cyclin-dependent kinase CDK2 phosphorylates the Treg transcription factor Foxp3, targeting it for proteolytic degradation. Treg with defective CDK2 activity express…
  • 2017 American Transplant Congress

    A New and Potent Distal Enhancer of the IL2 Gene.

    R. Thomas,1 P. Mehra,1 M. Johnson,2 S. Grant,2 A. Wells.1

    1Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA; 2Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA

    Interleukin-2 is a potent T cell growth factor with crucial roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role…
  • 2017 American Transplant Congress

    Anti-CD40 mAb Promotes Kidney Immunoregulatory Capacity in NHP Transplants by Altering Kidney Tubular Cell (TEC) Expression of CD40 and IL-6.

    J. Arp,1 Y. Ma,1 H. Yang,2 A. El Warrak,1 A. Haig,1 W. Liu,1 K. Reimann,3 P. Luke,1 Z. Zhang,1 D. Rothstein,4 A. Jevnikar.1

    1Medicine, Pathology & Microbiology & Immunology, Western University, London, ON, Canada; 2Sichuan Provincial Hospital, Chengdu, Sichuan, China; 3University of Massachusetts, Boston, MA; 4University of Pittsburgh, Pittsburgh, PA

    Treatment of cynolmolgus monkey (NHP) renal transplant recipients with a combination of 2 rhesus-mouse chimeric α-CD45RB (r6G3R1; 6G3) and α-CD40 (r2C10R4; 2C10) mAbs increased circulating…
  • 2017 American Transplant Congress

    Memory T Cells Are Decreased in Transplant Recipients Deficient in miR-182.

    V. Kaul, L. Wei, X. Qu, O. Martinez, S. Krams.

    Transplant Immunology Lab/Division of Abdominal Transplant, Stanford University, Stanford

    MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the post-transcriptional expression of target genes. There is ample evidence that miRNAs are involved in the…
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