2018 American Transplant Congress
Loss of HIF-1α in CD4 T Cell Improve Outcome of Mouse Vascularized Osteomyocutaneous Allotransplantation under Costimulation Blockade
Background: Allograft survival depends on the balance of effector T cells (Teff) and regulatory T cells (Tregs). Previous study suggested that the balance is controlled…2018 American Transplant Congress
Thymic Irradiation as a Maneuver for Repertoire Exchange in Costimulatory-Blockade-Based Immunotherapy
Background All successful, prospective clinical tolerance-induction strategies have employed thymic irradiation to achieve chimerism. However, evidence suggests durable chimerism is not required to attain tolerance.…2018 American Transplant Congress
Graft Dendritic Cell p40 Homodimers Activate Donor-Reactive Endogenous Memory CD8 T Cells within Higher Risk Allografts
Immunology, Cleveland Clinic, Cleveland, OH.
Memory T cells with donor-reactivity pose a major barrier to successful allograft transplantation and tolerance induction. Longer cold ischemic storage (CIS) prior to transplantation promotes…2018 American Transplant Congress
p40 Homodimer Induced Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High Risk Allografts Requires Memory CD8 T Cell Expression of CD122
Immunology, Cleveland Clinic, Cleveland, OH.
Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4 and…2017 American Transplant Congress
2B4-Mediated Inhibition of Proliferation and Glycolytic Function Attenuates T Cell Alloreactivity.
Emory Transplant Center, Atlanta, GA
Current thinking holds that costimulation-blockade resistant graft rejection may be mediated by CD28null T cells. To further investigate this possibility, we performed a retrospective immunophenotypic…2017 American Transplant Congress
IL-7 Receptor Heterogeneity as a Mechanism for Repertoire Change During Post-Depletional Homeostatic Proliferation and Its Relation to Costimulation Blockade Resistant Rejection.
Department of Surgery, Duke University School of Medicine, Durham, NC
Transplant patients treated with belatacept without depletional induction show high rates of costimulation blockade resistant rejection (CoBRR); this has been associated with CD57+ T cells.…2017 American Transplant Congress
Non-Invasive Detection of Rejection with ImmunoPET Imaging.
Current approaches to detect and diagnose rejection are retrospective and/or invasive. These methods assess the extent of end organ damage by insensitive and non-specific measures…2017 American Transplant Congress
Costimulation Independent Acute Rejection Requires CD127 Signaling.
Department of Surgery, Emory University, Atlanta, GA
Clinical costimulation blockade with belatacept leads to improved survival and graft function. However, a subset of patients experience costimulation independent rejection. We identified a critical…2017 American Transplant Congress
TFR:TFH Cell Ratio Correlates with Anti-Donor Germinal Center Reactivity and Donor-Specific Antibody Formation Following Transplantation.
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Although short-term outcomes are excellent, long-term allograft survival rates remain inadequate. It…2017 American Transplant Congress
How to Promote Regeneration After Ischemic Reperfusion Injury: Dual Role of CD 137 Agonistic Antibody.
Acute sterile inflammation can be induced by tissue damage caused by ischemia-reperfusion. In transplantation ischemia reperfusion injury (IRI) is unavoidable procedure. IRI causes delayed graft…
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