2018 American Transplant Congress
Enrichment of Endogenous Donor-Reactive Tregs in the Spleen and Graft during Transplantation Tolerance is the Result of Treg Proliferation and Conversion from Tconv
Surgery and Medicine, University of Chicago, Chicago, IL.
Foxp3+ regulatory T cells (Tregs) are critical mediators of immune tolerance and are absolutely required for allograft tolerance in animal models. In addition, clinical trials…2018 American Transplant Congress
The Infusion with a Difference: Patient Experiences with Belatacept
Yale University, New Haven, CT.
Introduction: The results of the BENEFIT trial led to the FDA approval of the novel anti-rejection agent belatacept (bela) in 2011. In addition to its…2018 American Transplant Congress
Inhibition of IL-1R1 Signaling Delays Costimulation Blockade–Resistant Allograft Rejection by Preventing CD8 TEM Expansion
Department of Surgery, Emory University, Atlanta, GA.
The clinical utilization of Costimulaiton Blockade (CoB) led to improved long-term patient outcomes, but wider adoption of is hampered by increased rates of acute cellular…2018 American Transplant Congress
Circulating T Follicular Helper Cells Expand Following Transplantation and Exhibit a CD44hi Phenotype That Correlates with Peak Germinal Center Alloreactivity
Emory Transplant Center, Atlanta.
It is increasingly well-recognized that donor-specific antibodies (DSA) play a significant role in the development of chronic rejection and fibrosis that contribute to late renal…2017 American Transplant Congress
TIM-4 Identifies Pro-Inflammatory B Effector Cells That Are Potent Drivers of Alloimmunity and Allograft Rejection Through Expression of Both IFN-γ and IL-17.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh
B cells can either augment or inhibit immune responses due to the presence both regulatory (Bregs) and effector (Beff) B cells expressing anti- or pro-…2017 American Transplant Congress
The Treg/Th17 Axis: A Dynamic Balance Regulated by Stromal Laminins.
University of Maryland, Baltimore
Background: Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively…2017 American Transplant Congress
A Regulatory T Cell (Treg)-Intrinsic Role for p27kip1 in Acquired Transplant Tolerance.
Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA
We previously found that the cyclin-dependent kinase CDK2 phosphorylates the Treg transcription factor Foxp3, targeting it for proteolytic degradation. Treg with defective CDK2 activity express…2017 American Transplant Congress
A New and Potent Distal Enhancer of the IL2 Gene.
Interleukin-2 is a potent T cell growth factor with crucial roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role…2017 American Transplant Congress
Anti-CD40 mAb Promotes Kidney Immunoregulatory Capacity in NHP Transplants by Altering Kidney Tubular Cell (TEC) Expression of CD40 and IL-6.
Treatment of cynolmolgus monkey (NHP) renal transplant recipients with a combination of 2 rhesus-mouse chimeric α-CD45RB (r6G3R1; 6G3) and α-CD40 (r2C10R4; 2C10) mAbs increased circulating…2017 American Transplant Congress
Memory T Cells Are Decreased in Transplant Recipients Deficient in miR-182.
Transplant Immunology Lab/Division of Abdominal Transplant, Stanford University, Stanford
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the post-transcriptional expression of target genes. There is ample evidence that miRNAs are involved in the…
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