Articles tagged "CD4"

2019 American Transplant Congress
Circulating Donor Specific Antibody and Biopsy C4d Positivity in Pancreas Rejection Increase the Probability of Earlier Return to Insulin after Rejection
S. M. Riad¹, S. Jackson², E. B. Finger³, R. Kandaswamy³
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Outcome data following rejection in pancreas recipients are sparse. We sought to study the influence of C4d positivity and the presence of circulating DSA…
2019 American Transplant Congress
Toll Like Receptor 2 Mobilizes Regulatory T Cell Lymphatic Migration by Stimulating Lymphotoxin Expression
W. Piao¹, Y. Xiong², L. Li³, V. Saxena³, C. Paluskievicz³, J. Bromberg⁴
¹Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, ²Surgery, U. Maryland, Baltimore, baltimore, MD, ³Surgery, U. Maryland, Baltimore, Baltimore, MD, ⁴Surgery and Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Regulatory T cell (Treg) afferent lymphatic migration is important for islet allograft survival. Treg express high levels of lymphotoxin (LT) and bind the LT…
2019 American Transplant Congress
Laminin α5 Deficiency in Lymph Node Stromal Cells Promotes Treg Migration and Allograft Survival
L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, T. Simon, N. Toney, C. Paluskievicz, J. S. Bromberg
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Laminins are a family of heterotrimeric glycoproteins, and lymph node (LN) stromal laminins α4 and α5 modulate suppression and immunity, respectively. We created laminin…
2019 American Transplant Congress
Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression
W. Piao¹, L. Li², V. Saxena², Y. Xiong², C. Paluskievicz², J. Bromberg³
¹Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, ²Surgery, U. Maryland, Baltimore, Baltimore, MD, ³Surgery and Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…
2019 American Transplant Congress
Effect of Induction Therapy on Absolute CD4 Count and CD4 Percentage in HIV Positive Kidney Transplant Recipients
S. A. Kuten¹, I. E. Dunne¹, A. E. Cantwell¹, M. J. Hobeika², S. G. Yi², W. Musick¹, R. J. Knight², A. O. Gaber²
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Anti-thymocyte globulin (ATG) induction causes profound and long-lasting lymphocyte depletion, with CD4+ reconstitution lagging behind other subsets. While absolute CD4 count is the preferred…
2019 American Transplant Congress
The Inverted Renal CD4/CD8 Ratio Associated with the Development of Transplant Glomerulopathy and Arteriosclerosis
B. H. Ozdemir¹, F. N. Ozdemir², A. Ok Atılgan¹, E. Akcay¹, M. Haberal³
¹Pathology, Baskent University, Ankara, Turkey, ²Nephrology, Baskent University, Ankara, Turkey, ³Transplantation, Baskent University, Ankara, Turkey
*Purpose: Inversion of the CD4/CD8 ratio (
2019 American Transplant Congress
Thymoglobulin Induction with Tacrolimus and Everolimus Maintenance Therapy in Elderly Kidney Transplantation Results in Prolonged Lymphocyte Depletion and Do Not Favor Regulatory Profile
E. David-Neto¹, G. Ramos de Freitas¹, M. Fernandes¹, F. Agena¹, F. Brambate Carvalhinho Lemos¹, F. Jota de Paula¹, V. Coelho², N. Zocoler Galante¹
¹Renal Transplantation Service, Hospital das Clínicas - University of São Paulo School of Medicine, Sao Paulo, Brazil, ²Laboratory of Immunology – LIM 19, Heart Institute - University of São Paulo School of Medicine, Sao Paulo, Brazil
*Purpose: Despite the growing number of elderly kidney transplant (Ktx) recipientes few studies describe the effects of immunosuppression on this group. We evaluated the immunological…
2019 American Transplant Congress
Laminin Dependent T Cell Migration Determines Allograft Survival
L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, B. M. Cerel, C. Paluskievicz, J. S. Bromberg
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Differential expression of lymph node (LN) stromal laminins α5β1γ1 (511) and α4β1γ1 (411) is associated with tolerance and immunity, respectively. We investigated the hypothesis…
2018 American Transplant Congress
Allogeneic T Follicular and T Conventional Responses Assessed by Proliferation, Cytokine Production, and TCR Clonality
C. Macedo,¹ M. Yamada,¹ X. Gu,¹ M. Suchoroski,² D. Hamm,² M. Kaplan,² D. Metes.¹
¹Thomas E. Starzl Transplantation Institute, Pittsburgh; ²Adaptive Biotechnologies, Seattle.
Background: Human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. Our previous analysis showed that allo-reactive precursors were present in…
2018 American Transplant Congress
OX40 Costimulation Prevents Induction of Foxp3⁺ Tregs through Upregulation of Novel Repressors of Foxp3 Gene Expression
X. Zhang,¹ X. Xiao,¹ P. Lan,¹ J. Li,¹ Y. Dou,¹ W. Chen,¹ N. Ishii,² S. Chen,¹ E. Taparowsky,³ X. Li.^1,4
¹Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX; ²Department of Microbiology and Immunology, Tohoku University, Sendai, Japan; ³Department of Biological Sciences, Perdue University, Lafayette, IN; ⁴Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
Foxp3+ Tregs are essential for the induction of transplant tolerance and OX40 costimulation is known to break transplant tolerance. The exact mechanism of OX40 in…