2019 American Transplant Congress
CD4 T Cell-Derived NGAL Mediates Experimental Acute Kidney Injury
*Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) is a potential biomarker for early detection of acute kidney injury (AKI) in human, but the mechanistic role for NGAL…2019 American Transplant Congress
Circulating Donor Specific Antibody and Biopsy C4d Positivity in Pancreas Rejection Increase the Probability of Earlier Return to Insulin after Rejection
*Purpose: Outcome data following rejection in pancreas recipients are sparse. We sought to study the influence of C4d positivity and the presence of circulating DSA…2019 American Transplant Congress
Toll Like Receptor 2 Mobilizes Regulatory T Cell Lymphatic Migration by Stimulating Lymphotoxin Expression
*Purpose: Regulatory T cell (Treg) afferent lymphatic migration is important for islet allograft survival. Treg express high levels of lymphotoxin (LT) and bind the LT…2019 American Transplant Congress
Laminin α5 Deficiency in Lymph Node Stromal Cells Promotes Treg Migration and Allograft Survival
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Laminins are a family of heterotrimeric glycoproteins, and lymph node (LN) stromal laminins α4 and α5 modulate suppression and immunity, respectively. We created laminin…2019 American Transplant Congress
Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression
*Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…2019 American Transplant Congress
Effect of Induction Therapy on Absolute CD4 Count and CD4 Percentage in HIV Positive Kidney Transplant Recipients
*Purpose: Anti-thymocyte globulin (ATG) induction causes profound and long-lasting lymphocyte depletion, with CD4+ reconstitution lagging behind other subsets. While absolute CD4 count is the preferred…2019 American Transplant Congress
The Inverted Renal CD4/CD8 Ratio Associated with the Development of Transplant Glomerulopathy and Arteriosclerosis
*Purpose: Inversion of the CD4/CD8 ratio (2019 American Transplant Congress
Thymoglobulin Induction with Tacrolimus and Everolimus Maintenance Therapy in Elderly Kidney Transplantation Results in Prolonged Lymphocyte Depletion and Do Not Favor Regulatory Profile
*Purpose: Despite the growing number of elderly kidney transplant (Ktx) recipientes few studies describe the effects of immunosuppression on this group. We evaluated the immunological…2018 American Transplant Congress
Effect of Induction Therapy on CD4 Cell Count Recovery Following Renal Transplantation in HIV Positive Recipients – A Single Center Experience
Department of Transplantation, Mayo Clinic College of Medicine, Jacksonville, FL.
The feasibility, complications and outcomes of solid organ transplantation in the HIV positive population are well documented and have had excellent outcomes with a slight…2018 American Transplant Congress
Enrichment of Endogenous Donor-Reactive Tregs in the Spleen and Graft during Transplantation Tolerance is the Result of Treg Proliferation and Conversion from Tconv
Surgery and Medicine, University of Chicago, Chicago, IL.
Foxp3+ regulatory T cells (Tregs) are critical mediators of immune tolerance and are absolutely required for allograft tolerance in animal models. In addition, clinical trials…
American Transplant Congress abstracts