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Articles tagged "CD4"

  • 2022 American Transplant Congress

    The Role of T Lymphocyte Subsets in Kidney Transplantation

    L. Vagiotas1, A. Xochelli2, E. Sampani3, V. Nikolaidou2, D. Asouchidou2, E. Kasimatis3, N. Antoniadis1, M. Daoudaki4, M. Stangou3, A. Papagianni3, G. Tsoulfas1, A. Fylaktou2

    1Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, 2National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, 3Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, 4Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece

    *Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…
  • 2021 American Transplant Congress

    Targeting Il-21 Receptor Shifts Tfh/tfr Balance and Ameliorateschronic Antibody Mediated Rejection

    Y. Nian, Z. Xiong, J. Zhao, Y. Fu

    Tianjin First Central Hospital, Tianjin, China

    *Purpose: Donor specific antibody (DSA) plays a central role in chronic kidney allograft injury. As a trigger of humoral alloimmune response, follicular T helper cells(Tfh)…
  • 2021 American Transplant Congress

    CD80/PD-L1 Uniquely Regulates CD4 Effector T Cell Migration

    W. Piao1, L. Li1, Y. Zhang2, K. Hippen2, M. WillsonShirkey1, B. Blazar2, L. Riella3, J. Bromberg1

    1U Maryland, baltimore, MD, 2U Minnesota, Minneapolis, MN, 3Harvard U, boston, MA

    *Purpose: CD80 is a costimulatory molecule expressed on antigen presenting cells (APCs) that binds CD28 and CTLA4, stimulating or inhibiting immunity, respectively. CD80 also binds…
  • 2021 American Transplant Congress

    Peripheral Lymphocyte Profiling and Increased Risk of EBV Infection in Pediatric Liver Transplant Recipients

    V. M. Novara Gennuso1, T. Miloh2

    1Pediatrics, Miller School of Medicine- University of Miami, Miami, FL, 2Pediatrics, Miami Transplant Institute, Miami, FL

    *Purpose: Epstein-Barr virus “EBV” infection and post-transplant lymphoproliferative disorders “PTLD” are significant comorbidities in the post-transplant “PT” setting, especially in pediatrics. The synergy among T…
  • 2021 American Transplant Congress

    Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies

    R. G. Gill1, B. Mehrad2, C. M. Lin2

    1Surgery, University of Colorado Denver, Aurora, CO, 2Medicine, University of Florida, Gainesville, FL

    *Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…
  • 2021 American Transplant Congress

    Laminins Differentially Regulate Adaptive Alloimmune Responses

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA

    *Purpose: Lymph node (LN) stromal cell expressed laminin α4 (Lama4) and laminin α5 (Lama5) fibers are associated with tolerance and immunity, respectively. They regulate cell…
  • 2021 American Transplant Congress

    TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation

    A. C. van der List, N. H. Litjens, M. G. Betjes, M. Klepper

    Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands

    *Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…
  • 2020 American Transplant Congress

    Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, C. Paluskievicz1, J. Zhao2, R. Abdi2, J. S. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) regulates CD4 T cell migration and function. We hypothesized that stromal Lama5 regulates the structure of the lymph node (LN) microenvironment…
  • 2020 American Transplant Congress

    Evaluation of Pre-Transplant T Cell Exhaustion as a Mechanism for Immune Dysfunction and Recipient Risk of Death Following Liver Transplant

    K. E. Lunsford1, N. Aware2, K. Cleveland3, D. T. Nguyen4, E. A. Graviss4, L. J. Minze3, T. N. Eagar4, X. C. Li3, R. M. Ghobrial3

    1Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, 2Department of Surgery, Houston Methodist Hosptial, Houston, TX, 3Department of Surgery, Houston Methodist Hospital, Houston, TX, 4Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX

    *Purpose: Cirrhosis-related immune dysfunction likely contributes to early mortality following liver transplant (LT) resulting from infections. We previously identified a pre-transplant biomarker panel for immune…
  • 2020 American Transplant Congress

    Lymph Node Stromal Laminin Alpha5 Regulates Antigen Specific T Cell Adaptive Immunity

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, C. Paluskievicz1, J. Zhao2, R. Abdi2, J. S. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) is associated with immunity and regulates T cell entry and responses within the lymph node (LN). We hypothesized that stromal Lama5…
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