Articles tagged "CD4"

2022 American Transplant Congress
Pd-1 Licenses Activated Treg for Lymphatic Migration
W. Piao¹, L. Li¹, V. Saxena¹, K. Hippen², M. Shirkey¹, B. Blazar², I. Lape³, y. zhang³, J. Bromberg¹
¹Surgery, University of Maryland, Baltimore, MD, ²University of Minnesota, Minneapolis, MN, ³Harvard Medical School, Boston, MA
*Purpose: In addition to serving as fluid conduits, lymphatic vessels are critical portals for immune cell migration. Lymphatic endothelial cells (LECs) constitutively express high levels…
2022 American Transplant Congress
Cd80 on Effector T Cell Binds Pd-l1 on Lymphatic Endothelial Cells to Fine Tune Migration
W. Piao¹, V. Saxena¹, L. Li¹, K. Hippen², Y. Zhang², B. Blazar², I. Lape³, L. Riella³, J. Bromberg¹
¹Surgery, University of Maryland, Baltimore, MD, ²University of Minnesota, Minneapolis, MN, ³Harvard Medical School, Boston, MA
*Purpose: Antigen presenting cell (APC) CD80 trans-binds CD28 and CTLA4 on T cells, boosting or inhibiting immunity, respectively. CD80 has another ligand, Programmed Death-1 Ligand…
2022 American Transplant Congress
Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells
K. Iwasaki¹, T. Tomosugi², T. Sekiya³, H. Hamana⁴, Y. Miwa¹, K. Futamura², M. Okada², T. Hiramitsu², N. Goto², S. Narumi², Y. Watarai², H. Kishi⁴, M. Okumura⁵, S. Ashimine⁵, K. Ishiyama⁵, T. Kobayashi⁵
¹Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, ²Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, ³Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, ⁴Department of Immunology, University of Toyama, Toyama, Japan, ⁵Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
*Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
2022 American Transplant Congress
Identification of Highly-Effective Donor-Reactive CD4⁺CD8α^lo T Cells in CTLA4Ig-Treated Renal Allograft Recipient Monkeys
M. Kubo, K. Sasaki, L. Lu, V. Vujevich, A. Thomson, M. Ezzelarab
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Potent CD4+CD8αlo effector T cells have been reported in transplant (tx) patients. . We evaluated the incidence and function of CD4+CD8αloT cells in renal…
2022 American Transplant Congress
CD40 Expressed by FRC Regulates Lymph Node Structure and Function
M. W. Shirkey¹, L. Li¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland School of Medicine, Baltimore, MD, ²Transplant Research Center, Harvard Medical School, Boston, MA
*Purpose: Fibroblastic reticular cells (FRC) support lymph node (LN) structure and can regulate T cell function through the CD40-CD40L pathway. Our previous work showed that…
2022 American Transplant Congress
Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity
L. Li¹, M. Shirkey¹, T. Zhang¹, W. Piao¹, V. Saxena¹, Z. Mei¹, Y. Guo¹, A. Krupnick¹, A. Kensiski¹, S. Gavzy¹, R. Abdi², J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…
2022 American Transplant Congress
Utility of Cytomegalovirus T-Cell Immunity Panel to Predict CMV Infections in Lung Transplant Recipients
R. W. Lincoln¹, B. J. Pierce¹, C. Pham¹, S. W. Yau², A. Goodarzi², J. G. Youssef², H. J. Huang²
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²Pulmonology, Houston Methodist Hospital, Houston, TX
*Purpose: Given the limited data of cytomegalovirus T-cell immunity panels (CMV TCIP) in lung transplant recipients (LTR), we sought to describe our center’s experience with…
2022 American Transplant Congress
Alloprimed Antibody-Suppressor CD8⁺ TCells Preferentially Kill Alloprimed Germinal Center B Cells
J. Zimmerer, S. Chaudhari, G. Bumgardner
OSUWMC, Columbus, OH
*Purpose: Antibody-mediated rejection (AMR) is a significant contributor to transplant rejection. Our prior work identified a novel subset of CXCR5+CD8+ T cells (CD8+ TAb-supp cells)…
2022 American Transplant Congress
Batf3 and IRF4 in Control of iTreg Differentiation, Stability, and Survival
P. Arnold, X. Xiao, X. Zhang, M. Wen, G. Wang, X. Chu, X. C. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: The use of in vitro-differentiated induced Tregs (iTregs) in transplantation and various diseases is a promising therapeutic that is limited by challenges to iTreg…
2022 American Transplant Congress
The Role of T Lymphocyte Subsets in Kidney Transplantation
L. Vagiotas¹, A. Xochelli², E. Sampani³, V. Nikolaidou², D. Asouchidou², E. Kasimatis³, N. Antoniadis¹, M. Daoudaki⁴, M. Stangou³, A. Papagianni³, G. Tsoulfas¹, A. Fylaktou²
¹Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ²National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, ³Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ⁴Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece
*Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…

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