ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Brain death"

  • 2015 American Transplant Congress

    The Use of Systems Biology to Identify Mitochondrial Dysfunction and Metabolic Dysregulation as Targets for Intervention in the Brain Dead Organ Donor

    M. Akhtar, L. Lo Faro, R. Robelledo, M. Kaisar, H. Huang, H. Leuvenink, P. Friend, S. Fuggle, C. Pugh, R. Ploeg.

    Oxford Transplant Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom.

    Introduction: Due to the persistent donor shortage many centres accept older, higher risk organs which have inferior outcomes. Understanding how kidneys are injured during brain…
  • 2015 American Transplant Congress

    Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation

    M. Kaisar,1,2 H. Huang,1,2 Z. Akhtar,1 H. Leuvenink,3 B. Kessler,2 R. Ploeg.1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; 2Target Discovery Institute, University of Oxford, Oxford, United Kingdom; 3Surgical Research Laboratory, UMC, Groningen, Netherlands.

    IntroductionDespite the persistent shortage of donor organs, paradoxically, many organs obtained from older higher risk donors are deemed unsuitable for transplantation and discarded. The ability…
  • 2015 American Transplant Congress

    Decreased Expression of Mitochondrial Aldehyde Dehydrogenase 2 Induces Liver Injury Via Activation of the MAPK Pathway in Grafts from Brain-Dead Donors

    Z. Zhong,1 S. Ye,1 Y. Xiong,1 X. Fan,1 W. Huang,1 D. Ko,3 Y. Wang,1 Q. Ye.1,2

    1Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; 2The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; 3Massachusetts General Hospital, Department of Urology, Boston, MA.

    Objective: To determine the role of ALDH2 in the injury of liver from brain-dead donors.Methods: Using brain-dead rabbit model, the expression of ALDH2 and apoptosis…
  • 2015 American Transplant Congress

    The Impact of Duration of Brain Death on Outcomes in Abdominal Organ Transplantation: Rush and Retrieve or Rather Relax and Repair?

    C. Boffa,1 E. Curnow,2 K. Martin,2 R. Johnson,2 R. Ploeg.1

    1Nuffield Department of Surgical Sciences, Oxford, United Kingdom; 2NHS Blood and Transplant, Bristol, United Kingdom.

    Background: Brain death (BD) induces a progressive systemic pro-inflammatory and coagulatory response affecting function of the grafts-to-be and survival. With longer BD duration more injury…
  • 2015 American Transplant Congress

    Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function

    J. Chen, S. Antipenko, A. Zmijewska, R. Reed, J. Locke, R. Mannon.

    Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.

    Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…
  • 2015 American Transplant Congress

    Remote Ischemic Preconditioning Increases Transplantation of Abdominal Organs in Standard Criteria Neurological Death Donors

    A. Bongu,1 W. Washburn,2 J. Oliver,1 J. Nespral,3 A. Davidow,4 C. Kadric,3 G. Dikdan,1 J. Lewis,2 U. Pandit,1 A.-K. Beidas,1 C. Tourtellot,3 L. Brown,1 B. Koneru.1

    1Surgery, Rutgers-New Jersey Medical School, Newark, NJ; 2Surgery, University of Texas Health Science Center, San Antonio, TX; 3Texas Organ Sharing Alliance, San Antonio, TX; 4Preventive Medicine, Rutgers-New Jersey Medical School, Newark, NJ.

    Background: Remote ischemic preconditioning (RIPC) induces innate protective mechanisms in remote organs. We hypothesized RIPC soon after neurological death (ND) would improve donor organ function…
  • 2015 American Transplant Congress

    Speed of Onset of Donor Brain Death Leads to Differences in Renal Function and Expression of Inflammatory and Oxidative Stress Markers in Rat Kidneys

    D. Hoeksma,1 R. Rebolledo,2 M. Hottenrott,3 Y. Bodar,1 H. Leuvenink.1

    1Abdominal Surgery, University Medical Center Groningen, Groningen, Netherlands; 2Faculty of Medicine, University of Chile, Santiago, Chile; 3Cardiothoracic Surgery, University Medical Center Groningen, Groningen, Netherlands.

    IntroductionDonor brain death (BD) is an independent risk factor for primary and delayed renal graft function. Furthermore, the speed of onset of brain death, traumatic…
  • 2015 American Transplant Congress

    Anti-Apoptotic But Not Mitotic Effects of 3,3',5-triiodo-l-thyronine in the Liver of Brain Dead Rats

    A. van Erp,1 R. Rebolledo,2 J. Wiersema-Buist,1 P. Ottens,1 H. Leuvenink,1 P. Romanque.2

    1Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; 2Department of Surgery, University of Chile, Santiago, Chile.

    Thyroid hormone treatment in brain dead organ donors has been extensively studied and applied in the clinical setting. However, its effectiveness remains controversial due to…
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