Articles tagged "Brain death"

2015 American Transplant Congress
Nomogram for Predicting Patient Survival After Withdrawal of Life-Sustaining Treatment in Patients With Devastating Neurological Injury
G. Xu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, guangzhou, China; Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, guangzhou, China.
Objective:Reliable prediction of time of death after withdrawal of life-sustaining treatment in patients with devastating neurological injury is crucial to successful donation after circulatory death.…
2015 American Transplant Congress
Declaring a Patient Brain Dead on Extracorporeal Membrane Oxygenation (ECMO): Are There Guidelines or Misconceptions?
K. Kreitler,¹ N. Cavarocchi,¹ H. Hirose,¹ S. West,² R. Hasz,² M. Ghobrial,³ R. Bell.³
¹Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA; ²Gift of Life Donor Program, Philadelphia, PA; ³Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA.
Purpose: With the rapid growth of ECMO and the accumulating evidence that organs from ECMO donors can be safely transplanted, we reviewed the practice variations…
2015 American Transplant Congress
Increase in Neurologic Determination of Death (NDD) Organ Donation in the Donation After Circulatory Death (DCD) Era. The Ontario Experience
J. Zaltzman,^1,2 J. MacLean,² C. Payne,² E. Paltser,² V. Rao,³ S. Dhanani.^2,4
¹Medicine, Nephrology & Transplant, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; ²Trillium Gift of Life Network, Ontario, Toronto, ON, Canada; ³Cardiovascular Surgery and Multi-Organ Transplant, University Health Network, University of Toronto, Toronto, ON, Canada; ⁴Pediatric Critical Care, Children's Hospital of Eastern Ontario, Univeristy of Ottawa, Ottawa, ON, Canada.
Some jurisdictions have reported a decrease in neurologic determination of death organ donors (NDD) with the implementation of donation after circulatory death (DCD) organ donation.…
2015 American Transplant Congress
Down-Regulation of Autophagy Correlates With Increased Apoptosis in the Kidney, But Not in the Liver, of Brain Dead Rats
A. van Erp,¹ R. Rebolledo,³ P. Ottens,¹ J. Pirenne,² H. Leuvenink,¹ J.-P. Decuypere.²
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Microbiology and Immunology, Catholic University Leuven, Leuven, Belgium; ³Department of Surgery, University of Chile, Santiago, Chile.
Organs from brain dead donors have inferior quality and show higher rejection rates after transplantation compared to living donors. Brain death (BD) in the donor…
2015 American Transplant Congress
The Use of Systems Biology to Identify Mitochondrial Dysfunction and Metabolic Dysregulation as Targets for Intervention in the Brain Dead Organ Donor
M. Akhtar, L. Lo Faro, R. Robelledo, M. Kaisar, H. Huang, H. Leuvenink, P. Friend, S. Fuggle, C. Pugh, R. Ploeg.
Oxford Transplant Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Introduction: Due to the persistent donor shortage many centres accept older, higher risk organs which have inferior outcomes. Understanding how kidneys are injured during brain…
2015 American Transplant Congress
Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation
M. Kaisar,^1,2 H. Huang,^1,2 Z. Akhtar,¹ H. Leuvenink,³ B. Kessler,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, University of Oxford, Oxford, United Kingdom; ³Surgical Research Laboratory, UMC, Groningen, Netherlands.
IntroductionDespite the persistent shortage of donor organs, paradoxically, many organs obtained from older higher risk donors are deemed unsuitable for transplantation and discarded. The ability…
2015 American Transplant Congress
Decreased Expression of Mitochondrial Aldehyde Dehydrogenase 2 Induces Liver Injury Via Activation of the MAPK Pathway in Grafts from Brain-Dead Donors
Z. Zhong,¹ S. Ye,¹ Y. Xiong,¹ X. Fan,¹ W. Huang,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Objective: To determine the role of ALDH2 in the injury of liver from brain-dead donors.Methods: Using brain-dead rabbit model, the expression of ALDH2 and apoptosis…
2015 American Transplant Congress
The Impact of Duration of Brain Death on Outcomes in Abdominal Organ Transplantation: Rush and Retrieve or Rather Relax and Repair?
C. Boffa,¹ E. Curnow,² K. Martin,² R. Johnson,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, Oxford, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom.
Background: Brain death (BD) induces a progressive systemic pro-inflammatory and coagulatory response affecting function of the grafts-to-be and survival. With longer BD duration more injury…