Articles tagged "Brain death"

2015 American Transplant Congress
Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function
J. Chen, S. Antipenko, A. Zmijewska, R. Reed, J. Locke, R. Mannon.
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…
2015 American Transplant Congress
Remote Ischemic Preconditioning Increases Transplantation of Abdominal Organs in Standard Criteria Neurological Death Donors
A. Bongu,¹ W. Washburn,² J. Oliver,¹ J. Nespral,³ A. Davidow,⁴ C. Kadric,³ G. Dikdan,¹ J. Lewis,² U. Pandit,¹ A.-K. Beidas,¹ C. Tourtellot,³ L. Brown,¹ B. Koneru.¹
¹Surgery, Rutgers-New Jersey Medical School, Newark, NJ; ²Surgery, University of Texas Health Science Center, San Antonio, TX; ³Texas Organ Sharing Alliance, San Antonio, TX; ⁴Preventive Medicine, Rutgers-New Jersey Medical School, Newark, NJ.
Background: Remote ischemic preconditioning (RIPC) induces innate protective mechanisms in remote organs. We hypothesized RIPC soon after neurological death (ND) would improve donor organ function…
2015 American Transplant Congress
Speed of Onset of Donor Brain Death Leads to Differences in Renal Function and Expression of Inflammatory and Oxidative Stress Markers in Rat Kidneys
D. Hoeksma,¹ R. Rebolledo,² M. Hottenrott,³ Y. Bodar,¹ H. Leuvenink.¹
¹Abdominal Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Faculty of Medicine, University of Chile, Santiago, Chile; ³Cardiothoracic Surgery, University Medical Center Groningen, Groningen, Netherlands.
IntroductionDonor brain death (BD) is an independent risk factor for primary and delayed renal graft function. Furthermore, the speed of onset of brain death, traumatic…
2015 American Transplant Congress
Anti-Apoptotic But Not Mitotic Effects of 3,3',5-triiodo-l-thyronine in the Liver of Brain Dead Rats
A. van Erp,¹ R. Rebolledo,² J. Wiersema-Buist,¹ P. Ottens,¹ H. Leuvenink,¹ P. Romanque.²
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Surgery, University of Chile, Santiago, Chile.
Thyroid hormone treatment in brain dead organ donors has been extensively studied and applied in the clinical setting. However, its effectiveness remains controversial due to…
2015 American Transplant Congress
Nomogram for Predicting Patient Survival After Withdrawal of Life-Sustaining Treatment in Patients With Devastating Neurological Injury
G. Xu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, guangzhou, China; Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, guangzhou, China.
Objective:Reliable prediction of time of death after withdrawal of life-sustaining treatment in patients with devastating neurological injury is crucial to successful donation after circulatory death.…
2015 American Transplant Congress
Declaring a Patient Brain Dead on Extracorporeal Membrane Oxygenation (ECMO): Are There Guidelines or Misconceptions?
K. Kreitler,¹ N. Cavarocchi,¹ H. Hirose,¹ S. West,² R. Hasz,² M. Ghobrial,³ R. Bell.³
¹Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA; ²Gift of Life Donor Program, Philadelphia, PA; ³Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA.
Purpose: With the rapid growth of ECMO and the accumulating evidence that organs from ECMO donors can be safely transplanted, we reviewed the practice variations…
2015 American Transplant Congress
Increase in Neurologic Determination of Death (NDD) Organ Donation in the Donation After Circulatory Death (DCD) Era. The Ontario Experience
J. Zaltzman,^1,2 J. MacLean,² C. Payne,² E. Paltser,² V. Rao,³ S. Dhanani.^2,4
¹Medicine, Nephrology & Transplant, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; ²Trillium Gift of Life Network, Ontario, Toronto, ON, Canada; ³Cardiovascular Surgery and Multi-Organ Transplant, University Health Network, University of Toronto, Toronto, ON, Canada; ⁴Pediatric Critical Care, Children's Hospital of Eastern Ontario, Univeristy of Ottawa, Ottawa, ON, Canada.
Some jurisdictions have reported a decrease in neurologic determination of death organ donors (NDD) with the implementation of donation after circulatory death (DCD) organ donation.…
2015 American Transplant Congress
Down-Regulation of Autophagy Correlates With Increased Apoptosis in the Kidney, But Not in the Liver, of Brain Dead Rats
A. van Erp,¹ R. Rebolledo,³ P. Ottens,¹ J. Pirenne,² H. Leuvenink,¹ J.-P. Decuypere.²
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Microbiology and Immunology, Catholic University Leuven, Leuven, Belgium; ³Department of Surgery, University of Chile, Santiago, Chile.
Organs from brain dead donors have inferior quality and show higher rejection rates after transplantation compared to living donors. Brain death (BD) in the donor…