Articles tagged "Brain death"

2016 American Transplant Congress
The Immunologic Profile of Brain Death in Humans: A Whole-Body Analysis.
D. Carpenter,^1,2 N. Matsuoka,¹ J. Thome,^1,3 T. Granot,^1,3 C. Gordon,^1,3 B. Kumar,^1,3 T. Senda,^1,3 M. Miron,^1,3 J. Weiner,² A. Griesemer,^1,2 D. Farber.^1,2,3
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York City, NY; ²Surgery, Columbia University Medical Center, New York City, NY; ³Microbiology and Immunology, Columbia University Medical Center, New York City, NY.
Transplantation outcomes are believed to be influenced by a generalized inflammatory state caused by brain death itself or events in the peri-transplant period. Studies on…
2016 American Transplant Congress
Deceased Organ Donors with Zero Organs Transplanted: Why and How Can We Improve?
P. Lange,¹ S. Rudich,¹ N. Obaseki,¹ J. Punch.²
¹Medical Division, Gift of Life Michigan, Ann Arbor, MI; ²Surgery, University of Michigan, Ann Arbor, MI.
Organ recovery professionals and donor hospitals are under intense pressure to go to whatever lengths necessary to provide transplantable organs. However, such a mentality can…
2016 American Transplant Congress
The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific.
S. Michel,^1,2 M. Madariaga,¹ G. LaMuraglia II,¹ R. Colvin,³ E. Farkash,³ J. Allan,^1,4 D. Sachs,¹ K. Yamada,¹ J. Madsen.^1,5
¹Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Department of Cardiac Surgery, Ludwig-Maximilians-University, Munich, Germany; ³Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background. We have previously shown that 12 days of high-dose calcineurin inhibition induced tolerance in miniature swine transplanted with MHC mismatched lung or cotransplanted heart…
2016 American Transplant Congress
The Impact of Total Ischaemic Time, Donor Age and the Pathway of Donor Death on Graft Outcomes After Deceased Donor Kidney Transplantation.
G. Wong,¹ A. Teixeira-Pinto,¹ C. Jeremy,¹ C. Jonathan,¹ M. Stephen,² L. Wai.³
¹University of Sydney, Sydney, Australia; ²University of Adelaide, Adelaide, Australia; ³University of Western Sydney, Perth, Australia.
Prolonged ischaemia is a known risk factor for delayed graft function and its interaction with donor characteristics, the pathways of donor death and graft outcomes…
2016 American Transplant Congress
Delayed Graft Function (DGF) Doesn't Affect Adversely the Long-Term Survival of Renal Transplantations (RT) from Uncontrolled Donation After Cardiac Death (UDCD) as Compared with RT from Standard Criteria Donor (SCD).
M. Molina,¹ J. Cabrera,² E. Gonzalez,¹ E. Gutierrez,¹ E. Morales,¹ E. Hernandez,¹ M. Praga,¹ A. Andres.¹
¹Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain; ²Nephrology, Hospital de Clínicas, Montevideo, Uruguay.
INTRODUCTION: DGF is a well-known risk factor for long-term kidney survival in RT. DGF hasn't been evaluated in RT from SCD and from UDCD donors.AIM:…
2016 American Transplant Congress
Predictors of Urologic Complications After Pediatric En-Bloc Donor Kidney Transplantation.
S. Kabagambe,¹ A. De Mattos,² R. Perez,¹ C. Santhanakrishnan,¹ J. Sageshima,¹ C. Troppmann,¹ J. McVicar.¹
¹Surgery, University of California-Davis, Sacramento, CA; ²Transplant Nephrology, University of California-Davis, Sacramento, CA.
Pediatric en-bloc kidney transplant (PEBKT) has expanded the donor pool. Association of donor characteristics and urologic complications is not well described. The objective of this…
2015 American Transplant Congress
The Use of Systems Biology to Identify Mitochondrial Dysfunction and Metabolic Dysregulation as Targets for Intervention in the Brain Dead Organ Donor
M. Akhtar, L. Lo Faro, R. Robelledo, M. Kaisar, H. Huang, H. Leuvenink, P. Friend, S. Fuggle, C. Pugh, R. Ploeg.
Oxford Transplant Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Introduction: Due to the persistent donor shortage many centres accept older, higher risk organs which have inferior outcomes. Understanding how kidneys are injured during brain…
2015 American Transplant Congress
Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation
M. Kaisar,^1,2 H. Huang,^1,2 Z. Akhtar,¹ H. Leuvenink,³ B. Kessler,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, University of Oxford, Oxford, United Kingdom; ³Surgical Research Laboratory, UMC, Groningen, Netherlands.
IntroductionDespite the persistent shortage of donor organs, paradoxically, many organs obtained from older higher risk donors are deemed unsuitable for transplantation and discarded. The ability…
2015 American Transplant Congress
Decreased Expression of Mitochondrial Aldehyde Dehydrogenase 2 Induces Liver Injury Via Activation of the MAPK Pathway in Grafts from Brain-Dead Donors
Z. Zhong,¹ S. Ye,¹ Y. Xiong,¹ X. Fan,¹ W. Huang,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Objective: To determine the role of ALDH2 in the injury of liver from brain-dead donors.Methods: Using brain-dead rabbit model, the expression of ALDH2 and apoptosis…
2015 American Transplant Congress
The Impact of Duration of Brain Death on Outcomes in Abdominal Organ Transplantation: Rush and Retrieve or Rather Relax and Repair?
C. Boffa,¹ E. Curnow,² K. Martin,² R. Johnson,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, Oxford, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom.
Background: Brain death (BD) induces a progressive systemic pro-inflammatory and coagulatory response affecting function of the grafts-to-be and survival. With longer BD duration more injury…