Articles tagged "Brain death"

2016 American Transplant Congress
The Immunologic Profile of Brain Death in Humans: A Whole-Body Analysis.
D. Carpenter,^1,2 N. Matsuoka,¹ J. Thome,^1,3 T. Granot,^1,3 C. Gordon,^1,3 B. Kumar,^1,3 T. Senda,^1,3 M. Miron,^1,3 J. Weiner,² A. Griesemer,^1,2 D. Farber.^1,2,3
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York City, NY; ²Surgery, Columbia University Medical Center, New York City, NY; ³Microbiology and Immunology, Columbia University Medical Center, New York City, NY.
Transplantation outcomes are believed to be influenced by a generalized inflammatory state caused by brain death itself or events in the peri-transplant period. Studies on…
2016 American Transplant Congress
Deceased Organ Donors with Zero Organs Transplanted: Why and How Can We Improve?
P. Lange,¹ S. Rudich,¹ N. Obaseki,¹ J. Punch.²
¹Medical Division, Gift of Life Michigan, Ann Arbor, MI; ²Surgery, University of Michigan, Ann Arbor, MI.
Organ recovery professionals and donor hospitals are under intense pressure to go to whatever lengths necessary to provide transplantable organs. However, such a mentality can…
2016 American Transplant Congress
The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific.
S. Michel,^1,2 M. Madariaga,¹ G. LaMuraglia II,¹ R. Colvin,³ E. Farkash,³ J. Allan,^1,4 D. Sachs,¹ K. Yamada,¹ J. Madsen.^1,5
¹Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Department of Cardiac Surgery, Ludwig-Maximilians-University, Munich, Germany; ³Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background. We have previously shown that 12 days of high-dose calcineurin inhibition induced tolerance in miniature swine transplanted with MHC mismatched lung or cotransplanted heart…
2016 American Transplant Congress
The Impact of Total Ischaemic Time, Donor Age and the Pathway of Donor Death on Graft Outcomes After Deceased Donor Kidney Transplantation.
G. Wong,¹ A. Teixeira-Pinto,¹ C. Jeremy,¹ C. Jonathan,¹ M. Stephen,² L. Wai.³
¹University of Sydney, Sydney, Australia; ²University of Adelaide, Adelaide, Australia; ³University of Western Sydney, Perth, Australia.
Prolonged ischaemia is a known risk factor for delayed graft function and its interaction with donor characteristics, the pathways of donor death and graft outcomes…
2016 American Transplant Congress
Delayed Graft Function (DGF) Doesn't Affect Adversely the Long-Term Survival of Renal Transplantations (RT) from Uncontrolled Donation After Cardiac Death (UDCD) as Compared with RT from Standard Criteria Donor (SCD).
M. Molina,¹ J. Cabrera,² E. Gonzalez,¹ E. Gutierrez,¹ E. Morales,¹ E. Hernandez,¹ M. Praga,¹ A. Andres.¹
¹Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain; ²Nephrology, Hospital de Clínicas, Montevideo, Uruguay.
INTRODUCTION: DGF is a well-known risk factor for long-term kidney survival in RT. DGF hasn't been evaluated in RT from SCD and from UDCD donors.AIM:…
2016 American Transplant Congress
Predictors of Urologic Complications After Pediatric En-Bloc Donor Kidney Transplantation.
S. Kabagambe,¹ A. De Mattos,² R. Perez,¹ C. Santhanakrishnan,¹ J. Sageshima,¹ C. Troppmann,¹ J. McVicar.¹
¹Surgery, University of California-Davis, Sacramento, CA; ²Transplant Nephrology, University of California-Davis, Sacramento, CA.
Pediatric en-bloc kidney transplant (PEBKT) has expanded the donor pool. Association of donor characteristics and urologic complications is not well described. The objective of this…
2015 American Transplant Congress
Nomogram for Predicting Patient Survival After Withdrawal of Life-Sustaining Treatment in Patients With Devastating Neurological Injury
G. Xu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, guangzhou, China; Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, guangzhou, China.
Objective:Reliable prediction of time of death after withdrawal of life-sustaining treatment in patients with devastating neurological injury is crucial to successful donation after circulatory death.…
2015 American Transplant Congress
Declaring a Patient Brain Dead on Extracorporeal Membrane Oxygenation (ECMO): Are There Guidelines or Misconceptions?
K. Kreitler,¹ N. Cavarocchi,¹ H. Hirose,¹ S. West,² R. Hasz,² M. Ghobrial,³ R. Bell.³
¹Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA; ²Gift of Life Donor Program, Philadelphia, PA; ³Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA.
Purpose: With the rapid growth of ECMO and the accumulating evidence that organs from ECMO donors can be safely transplanted, we reviewed the practice variations…
2015 American Transplant Congress
Increase in Neurologic Determination of Death (NDD) Organ Donation in the Donation After Circulatory Death (DCD) Era. The Ontario Experience
J. Zaltzman,^1,2 J. MacLean,² C. Payne,² E. Paltser,² V. Rao,³ S. Dhanani.^2,4
¹Medicine, Nephrology & Transplant, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; ²Trillium Gift of Life Network, Ontario, Toronto, ON, Canada; ³Cardiovascular Surgery and Multi-Organ Transplant, University Health Network, University of Toronto, Toronto, ON, Canada; ⁴Pediatric Critical Care, Children's Hospital of Eastern Ontario, Univeristy of Ottawa, Ottawa, ON, Canada.
Some jurisdictions have reported a decrease in neurologic determination of death organ donors (NDD) with the implementation of donation after circulatory death (DCD) organ donation.…
2015 American Transplant Congress
Down-Regulation of Autophagy Correlates With Increased Apoptosis in the Kidney, But Not in the Liver, of Brain Dead Rats
A. van Erp,¹ R. Rebolledo,³ P. Ottens,¹ J. Pirenne,² H. Leuvenink,¹ J.-P. Decuypere.²
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Microbiology and Immunology, Catholic University Leuven, Leuven, Belgium; ³Department of Surgery, University of Chile, Santiago, Chile.
Organs from brain dead donors have inferior quality and show higher rejection rates after transplantation compared to living donors. Brain death (BD) in the donor…