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American Transplant Congress abstracts

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Articles tagged "Brain death"

  • 2020 American Transplant Congress

    Less is More: A Single Brain Death Exam Improves Organ Donation Outcomes

    A. J. Matar1, H. Wichmann2, L. Kenney2, A. Subramanian3, J. Ratcliff4, V. Patel4, B. M. Tracy2, R. B. Gelbard2

    1Surgery and Transplantation, Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA, 3Surgery, Lawnwood Regional Medical Center, Fort Pierce, FL, 4Neurosurgery, Emory University, Atlanta, GA

    *Purpose: The diagnosis of brain death in adults has historically required two brain death examinations (TBD) before considering organ donation. Despite American Academy of Neurology…
  • 2020 American Transplant Congress

    A Large Animal Model of Ex-Vivo Lung Perfusion as a Platform to Deliver Therapeutic Agents to Lungs Before Lung Transplant

    T. M. Egan1, B. Haithcock1, M. H. Ali1, J. W. Blackwell1, B. Masuodi1, S. Shipley2, T. Long3, A. Akerman1, S. Montgomery4, H. Yuan5, P. Stewart6, J. Potenziano7, C. Sekaran7, R. Fitch7

    1Surgery, UNC at Chapel Hill, Chapel Hill, NC, 2Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 3Pathology and Laboratory Medicine,, UNC at Chapel Hill, Chapel Hill, NC, 4Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 5Radiology, UNC at Chapel Hill, Chapel Hill, NC, 6Gillings Global School of Public Health, UNC at Chapel Hill, Chapel Hill, NC, 7Mallinckrodt Pharmaceuticals, Hazelwood, MO

    *Purpose: Ex-vivo lung perfusion (EVLP) has been used to evaluate lung function before lung transplant (LT). We used EVLP to expose lungs recovered 6 hours…
  • 2020 American Transplant Congress

    Ex Vivo Normothermic Perfusion Improves Cold Ischemic Injury and DGF in an Experimental Model of DBD Kidney Transplantation

    A. Gutierrez-Dalmau1, V. Alastrue2, Á. García De Jalon3, M. Sánchez3, C. Del Agua4, V. P. González5, Á. Roncales3, J. Gómez-Arrue6, C. Pastor6, B. Sáez7, L. M. Esteban8, M. J. Gil3, M. Doblaré9, Á. Borque-Fernando3

    1Nephrology, Hospital Universitario Miguel Servet (HUMS), IIS Aragón, Zaragoza, Spain, 2EBERS, Zaragoza, Spain, 3Urology, HUMS, Zaragoza, Spain, 4Pathology, HUMS, Zaragoza, Spain, 5Hematology, HUMS, Zaragoza, Spain, 6Experimental Surgery, IACS, Zaragoza, Spain, 7Faculty of Health Sciences, San Jorge University, Zaragoza, Spain, 8EUPLA, Zaragoza University, Zaragoza, Spain, 9Department of Mechanical Engineering, Zaragoza University, Zaragoza, Spain

    *Purpose: Cold ischemic (CI) injury results in high rates of DGF, reduced graft function and survival. Ex vivo normothermic perfusion (EVNP) has shown to improve…
  • 2020 American Transplant Congress

    Comparison of Metabolic Outcomes after Pancreas Transplantation between DBD (Donors after Brainstem Death) and DCD (Donors after Circulatory Death) Grafts

    J. Gopal, A. McLean, J. Crane, P. Herbert, F. Dor, M. Reddy, D. Taube, V. Papalois, A. Muthusamy

    Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom

    *Purpose: DCD pancreas transplantation has become common with equivalent graft survival as that of DBD grafts, but are the metabolic outcomes similar? Given the lack…
  • 2020 American Transplant Congress

    Living versus Deceased Donor Liver Transplantation in Cholestatic Liver Disease: An Analysis of the OPTN Database

    I. A. Ziogas1, S. P. Alexopoulos1, L. K. Matsuoka1, S. K. Geevarghese1, L. D. Gorden1, S. J. Karp1, J. D. Perkins2, M. I. Montenovo1

    1Vanderbilt University Medical Center, Nashville, TN, 2University of Washington, Seattle, WA

    *Purpose: The current MELD allocation system does not accurately reflect the urgency of liver transplantation (LT) in cholestatic liver disease (CLD) patients. Therefore, more CLD…
  • 2020 American Transplant Congress

    Detrimental Effects of Donor Brain Death on Tolerance Induction May be Eliminated by Delaying Mixed Chimerism in Non-Human Primates

    J. M. O1, W. Sommer2, K. Ahrens1, P. Patel1, D. Becerra1, J. Morrissette1, T. Costa1, K. Pruner1, J. Paster1, A. Bean1, A. Dehnadi1, I. Hanekamp1, I. Rosales1, R. Smith1, R. Colvin1, G. Benichou1, J. Allan3, T. Kawai1, J. Madsen4

    1Center for Transplantation Sciences, MGH, Boston, MA, 2Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3Division of Thoracic Surgery, MGH, Boston, MA, 4Division of Cardiac Surgery, MGH, Boston, MA

    *Purpose: Induction of tolerance to heart allografts in non-human primates is possible with kidney cotransplantation and mixed chimerism-based induction therapy. However, donor brain death abrogates…
  • 2019 American Transplant Congress

    Determinants of Allograft Injury during Procurement in Deceased Donors

    E. Taber-Hight1, R. Cauwels2, E. Eidbo2, A. S. Paramesh3, R. Squires4, T. Taber1

    1Nephrology, Indiana University, Indianapolis, IN, 2AOPO, Vienna, VA, 3Louisiana Organ Procurement Agency, New Orleans, LA, 4University of Oklahoma, Oklahoma City, OK

    *Purpose: With the ever enlarging list of potential recipients on the transplant list, the need for deceased donor organs has become critical. Avoiding injury to…
  • 2019 American Transplant Congress

    Exendin-4 for Donor Treatment in a Brain-Death Model of Kidney Transplantation

    H. Yang1, L. Luo1, X. Li1, C. Long1, Y. Shi2, Y. Xiong3, M. Chen4, J. Gao5, H. Li6, Z. Wang6

    1Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, 2Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, 4Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, 5Department of Vascular Surgery, People's hospital of Jiangxi Province, Nanchang, China, 6Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Renal grafts from brain death donors associated with poorer graft outcomes after kidney transplantation, hemodynamic and inflammatory mechanisms can account for brain death induce…
  • 2019 American Transplant Congress

    Targeting Pyroptosis in Brain-Dead Donors Improves Renal Function after Transplantation in Rat

    H. Yang1, Y. Shi2, X. Li1, L. Luo1, C. Long1, Y. Xiong3, M. Chen4, J. Gao4, H. Li5, Z. Wang5

    1Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, 2Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, 4Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, 5Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Pyroptosis is a form of programmed cell death include necrosis, nuclear condensation, and release of proinflammatory after caspase-1 activation. It is unknown whether pyroptosis…
  • 2019 American Transplant Congress

    Significant Implications of Prior Transplantation on Treatment and Outcomes of Patients Suffering from Traumatic Brain Injury

    L. Mugge, W. Qu, C. Gallagher, A. Caras, N. Henkel, O. Ekwenna, J. Ortiz

    The University of Toledo Medical Center, Toledo, OH

    *Purpose: Recent events in the media and sporting industry highlight traumatic brain injury (TBI) as a major health concern, having implications in many areas of…
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