Articles tagged "Brain death"

2020 American Transplant Congress
Ex Vivo Normothermic Perfusion Improves Cold Ischemic Injury and DGF in an Experimental Model of DBD Kidney Transplantation
A. Gutierrez-Dalmau¹, V. Alastrue², Á. García De Jalon³, M. Sánchez³, C. Del Agua⁴, V. P. González⁵, Á. Roncales³, J. Gómez-Arrue⁶, C. Pastor⁶, B. Sáez⁷, L. M. Esteban⁸, M. J. Gil³, M. Doblaré⁹, Á. Borque-Fernando³
¹Nephrology, Hospital Universitario Miguel Servet (HUMS), IIS Aragón, Zaragoza, Spain, ²EBERS, Zaragoza, Spain, ³Urology, HUMS, Zaragoza, Spain, ⁴Pathology, HUMS, Zaragoza, Spain, ⁵Hematology, HUMS, Zaragoza, Spain, ⁶Experimental Surgery, IACS, Zaragoza, Spain, ⁷Faculty of Health Sciences, San Jorge University, Zaragoza, Spain, ⁸EUPLA, Zaragoza University, Zaragoza, Spain, ⁹Department of Mechanical Engineering, Zaragoza University, Zaragoza, Spain
*Purpose: Cold ischemic (CI) injury results in high rates of DGF, reduced graft function and survival. Ex vivo normothermic perfusion (EVNP) has shown to improve…
2020 American Transplant Congress
Comparison of Metabolic Outcomes after Pancreas Transplantation between DBD (Donors after Brainstem Death) and DCD (Donors after Circulatory Death) Grafts
J. Gopal, A. McLean, J. Crane, P. Herbert, F. Dor, M. Reddy, D. Taube, V. Papalois, A. Muthusamy
Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
*Purpose: DCD pancreas transplantation has become common with equivalent graft survival as that of DBD grafts, but are the metabolic outcomes similar? Given the lack…
2020 American Transplant Congress
Living versus Deceased Donor Liver Transplantation in Cholestatic Liver Disease: An Analysis of the OPTN Database
I. A. Ziogas¹, S. P. Alexopoulos¹, L. K. Matsuoka¹, S. K. Geevarghese¹, L. D. Gorden¹, S. J. Karp¹, J. D. Perkins², M. I. Montenovo¹
¹Vanderbilt University Medical Center, Nashville, TN, ²University of Washington, Seattle, WA
*Purpose: The current MELD allocation system does not accurately reflect the urgency of liver transplantation (LT) in cholestatic liver disease (CLD) patients. Therefore, more CLD…
2020 American Transplant Congress
Detrimental Effects of Donor Brain Death on Tolerance Induction May be Eliminated by Delaying Mixed Chimerism in Non-Human Primates
J. M. O¹, W. Sommer², K. Ahrens¹, P. Patel¹, D. Becerra¹, J. Morrissette¹, T. Costa¹, K. Pruner¹, J. Paster¹, A. Bean¹, A. Dehnadi¹, I. Hanekamp¹, I. Rosales¹, R. Smith¹, R. Colvin¹, G. Benichou¹, J. Allan³, T. Kawai¹, J. Madsen⁴
¹Center for Transplantation Sciences, MGH, Boston, MA, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Division of Thoracic Surgery, MGH, Boston, MA, ⁴Division of Cardiac Surgery, MGH, Boston, MA
*Purpose: Induction of tolerance to heart allografts in non-human primates is possible with kidney cotransplantation and mixed chimerism-based induction therapy. However, donor brain death abrogates…
2020 American Transplant Congress
A Stroke Volume-Based Fluid Resuscitation Protocol Decreases Vasopressor Support and Increases Organ Yield in Brain-Dead Donors
G. F. Marklin
Mid-America Transplant, St Louis, MO
*Purpose: Brain-dead donors are frequently hypovolemic and hypotensive requiring vasopressor support. The goal of fluid resuscitation is to increase perfusion and oxygen delivery and avoid…
2020 American Transplant Congress
Less is More: A Single Brain Death Exam Improves Organ Donation Outcomes
A. J. Matar¹, H. Wichmann², L. Kenney², A. Subramanian³, J. Ratcliff⁴, V. Patel⁴, B. M. Tracy², R. B. Gelbard²
¹Surgery and Transplantation, Emory University, Atlanta, GA, ²Surgery, Emory University, Atlanta, GA, ³Surgery, Lawnwood Regional Medical Center, Fort Pierce, FL, ⁴Neurosurgery, Emory University, Atlanta, GA
*Purpose: The diagnosis of brain death in adults has historically required two brain death examinations (TBD) before considering organ donation. Despite American Academy of Neurology…
2019 American Transplant Congress
Organ Donation is an Indication for Renal Replacement Therapy (RRT)
A. L. Friedman, E. Marquez, J. A. Lewis
LiveOnNY, New York, NY
*Purpose: A retrospective review of cases from one large organ procurement organization (OPO) was performed to determine whether the delivery of RRT as a component…
2019 American Transplant Congress
Pancreas Transplant Alone Using Donation After Cardiac Death Donors Has Similar Outcomes As Donation After Brain Death Donors
K. Espinoza¹, D. Wall¹, K. L. Lentine², J. R. Wellen¹, D. Hammad¹, D. C. Brennan³, T. Alhamad¹
¹Washinton University in St. Louis, St. Louis, MO, ²Saint Louis University, St. Louis, MO, ³Johns Hopkins University, St. Louis, MO
*Purpose: While outcomes of pancreas transplants are improving, there is a persistent hesitancy to use pancreas organs procured in the context of donation after cardiac…
2019 American Transplant Congress
Staged Procedure In Simultaneous Liver And Kidney Transplant -the “Swedish” Experience
A. Gravetz
Transplant Surgery, Swedish Medical Center, Seattle, WA
*Purpose: As many as 30% of liver transplant candidates have renal insufficiency requiring a combined liver and kidney transplantation. The prolonged and complex simultaneous liver-kidney…
2019 American Transplant Congress
Donor Management in Donation after Brain Death: A Window of Opportunity – Are Pro-Inflammatory Mediators the Target and What is the Effect of Duration of Brain Death?
K. D. Bera¹, J. Tabak², M. L. Lo Faro¹, R. J. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University of Exeter, Exeter, United Kingdom
*Purpose: Donation after brain death (BD) is a crucial source of transplanted organs - uncertainty remains how duration of BD contributes to outcomes: This study…