ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bone marrow"

  • 2020 American Transplant Congress

    Mechanisms by Which Donor Bone-Marrow CXCR4+ Foxp3+ Tregs Promote Long-Term Survival of Murine Limb Allografts

    L. Wang1, Z. Wang2, R. Han1, A. Samanta1, G. Ge1, L. S. Levin1, M. H. Levine1, W. W. Hancock3

    1Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

    *Purpose: Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance…
  • 2020 American Transplant Congress

    Dissecting Humoral Alloimmune Sensitization: A Dynamic Interplay of Different Cellular Compartments

    A. Torija, A. Favà, E. Crespo, M. Jarque, M. Meneghini, N. Bolaños, J. Grinyo, O. Bestard

    Kidney transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain

    *Purpose: Humoral alloimmune memory is the main barrier for successful transplantation and is generated by a complex and compartmentalized B-cell immune response. Understanding the role…
  • 2019 American Transplant Congress

    Adipose Stem Cells Promote Composite Tissue Engraftment

    N. Shockcor1, B. Buckingham1, W. Hassanein1, D. Parsell1, U. Dhru1, B. Akinsiku2, E. Elster2, T. Davis2, J. Gimble3, A. Nam1, S. Bartlett1, R. Barth1

    1Surgery, University of Maryland, Baltimore, MD, 2Uniformed Services University of the Health Sciences, Bethesda, MD, 3LaCell LLC, New Orleans, LA

    *Purpose: Adipose-derived stem cells (ASC) have increased levels of anti-inflammatory and immunoregulatory factors. Murine studies have shown stable macrochimerism and long-term full thickness skin graft…
  • 2019 American Transplant Congress

    Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation

    J. Fu1, J. Zuber1, B. Shonts1, A. Obradovic1, K. Frangaj1, E. E. Waffarn1, S. Lau1, T. M. Savage1, S. Yang1, K. Rogers1, P. Satwani2, S. Ho1, Y. Shen3, A. Griesemer4, M. Martinez2, T. Kato4, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Department of Systems Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…
  • 2018 American Transplant Congress

    Donor Bone Marrow CXCR4+ Foxp3+ Treg Cells Are Essential for Costimulation Blockade-Induced Long-Term Survival of Murine Limb Transplants

    L. Wang,1 Z. Wang,1 R. Han,1 G. Ge,1 L. Levin,2 M. Levine,2 W. Hancock.1,2

    1CHOP, Philadelphia; 2UPenn, Philadelphia.

    Vascularized composite allotransplantation (VCA) would likely be more widely performed if maintenance immunosuppression was not essential for graft acceptance. Accordingly, we used murine models of…
  • 2018 American Transplant Congress

    Pilot Study of Plasma Cell Niche-Targeted Therapy for Enhancement of Proteasome Inhibitor Effectiveness

    S. Tremblay,1 C. Castro-Rojas,2 J. Driscoll,1 S. Knechtle,3 A. Shields,1 R. Alloway,1 H. Singh,2 D. Hildeman,2 E. Woodle.1

    1UCincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham.

    HLA antibody (Ab)-secreting bone marrow (BM) plasma cell (PC) survival depends on niche occupancy via a CXCR4 (PC)-CXCL12 (BM stromal cell) interaction. Plerixafor inhibits CXCR4-CXCL12…
  • 2018 American Transplant Congress

    Comparative Analysis of Bone Marrow versus Blood Monocyte-Derived Regulatory Dendritic Cells for Evaluation in a Miniature Swine Vascular Composite Allotransplantation Model

    T. Elgendy,1 D. Kim,2 A. Zahorchak,1 M. Ezzelarab,1 M. Solari,2 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Background: Dendritic cell therapy is a promising approach to reduced dependence on immunosuppressive drugs and for the promotion of tolerance in transplant recipients. Our aim…
  • 2018 American Transplant Congress

    The Ratio of CTLA4 to Perforin and Granzyme B as a Potential Biomarker of Tolerance in Chimeric Renal Transplant Patients

    A. Khalil,1 A. Chhabra,1 A. Merchak,1 L. Kahn,1 J. Leventhal,2 S. Ildstad.1

    1Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; 2Northwestern University, Chicago, IL.

    Background: Thirty-six subjects have been enrolled in a phase II clinical trial aimed to induce tolerance through chimerism. Each subject received FCRx (mPBMC enriched in…
  • 2018 American Transplant Congress

    In Vivo Administration of Plerixafor and Bortezomib Results in Bone Marrow Plasma Cell Mobilization and Death While Inducing Biphasic Plasma Cell Apoptosis in Peripheral Blood

    E. Woodle,1 S. Tremblay,1 C. Castro-Rojas,2 S. Knechtle,3 A. Shields,1 R. Alloway,1 H. Singh,2 J. Driscoll,1 D. Hildeman.2

    1U Cincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham.

    Bone marrow (BM) plasma cells (PC) secreting HLA antibody (Ab) remain a persistent reservoir of donor specific Ab and present a significant hurdle to allograft…
  • 2018 American Transplant Congress

    Long Term Culture of Functional Bone Marrow-Derived Human Plasma Cells

    N. Moore, K. Bonner, M. D'Costa, M. Stegall.

    William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.

    Introduction Antibody-secreting plasma cells (PCs) are critically important for host defense, but also can cause antibody-mediated allograft rejection. The ability to study these cells is…
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