ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bone marrow"

  • 2022 American Transplant Congress

    Autologous Mesenchymal Stem Cells for Treatment of Chronic Antibody-Mediated Kidney Graft Rejection: Report of the First Phase I/II Clinical Case Series

    Ž. Večerić-Haler1, M. Sever2, N. Kojc3, G. Mlinšek1, M. Oblak1, P. Halloran4, A. Aleš Rigler1, J. Buturović Ponikvar1, M. Arnol5

    1Nephrology, UMC Ljubljans, Ljubljana, Slovenia, 2Haematology, UMC Ljubljans, Ljubljana, Slovenia, 3Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana,, Ljubljana, Slovenia, 4Division of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 5University Medical Centre Ljubljana, Ljubljana, Slovenia

    *Purpose: The aim of this study is to evaluate the safety and efficacy of autologous mesenchymal stem cellc (MSCs) in combination with standard of care…
  • 2022 American Transplant Congress

    Ikaros-SIRT1 Signaling Axis Regulates Macrophage Pyroptosis and Ischemia-Reperfusion Injury (IRI) in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, X. Li2, J. Kupiec-Weglinski1

    1UCLA Medical Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: Although Ikaros is a well-established regulator of lymphopoiesis, its role in myeloid cells and organ IRI remains unclear. We recently reported that the SIRT1-mediated…
  • 2022 American Transplant Congress

    Perturbing Proteostasis to Deplete Plasma Cells

    A. Rossi1, A. Burg1, K. Roskin1, A. Shields2, R. Alloway2, E. Woodle2, D. Hildeman1

    1Cincinnati Children's Hospital, Cincinnati, OH, 2University of Cincinnati College of Medicine, Cincinnati, OH

    *Purpose: Alloantibodies play critical roles in rejection and often prevent sensitized patients from receiving life-sustaining transplants. One approach for enhancing transplantation rates and survival for…
  • 2022 American Transplant Congress

    Bone Marrow Resident Long-Lived Plasma Cells as Source of Chronic Donor-Specific Antibodies

    M. Muckenhuber, S. Pichler, A. M. Weijler, T. Wekerle

    Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria

    *Purpose: The importance of bone marrow resident plasma cells for long-lasting humoral immunity has been highlighted in several models for vaccination and infectious diseases. To…
  • 2021 American Transplant Congress

    Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes

    D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky

    Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
  • 2021 American Transplant Congress

    Selective Bcl-2 Inhibition to Deplete Hematopoietic Stem Cells in Bone Marrow Niche: A Novel Approach to Promote Mixed Chimerism

    T. Hirose1, H. Sasaki1, G. Lassiter1, D. Ma1, T. Oura1, A. Dehnadi1, A. Cosimi1, P. Cippa2, T. Fehr2, T. Kawai1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Institute of Physiology, University of Zurich, Zurich, Switzerland

    *Purpose: A recent murine study has shown that successful mixed chimerism is achievable without myelosuppressive treatments by Bcl-2 inhibition. However, the mechanism by which selective…
  • 2021 American Transplant Congress

    Regulatory Macrophage Induced by Il-33 Promoted Immune Tolerance of Kidney Transplantation Through Siglec-10

    J. d. zhang, w. wang

    Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

    *Purpose: Acute and chronic rejection are key problems in renal transplantation. It is ideal to induce immune tolerance to suppress rejection while regulatory macrophages (Mregs)…
  • 2020 American Transplant Congress

    BAFF Inhibition to Prevent Antibody Rebound Following Proteasome Inhibitor-Based Desensitization: A Randomized, Controlled Trial

    S. Tremblay1, A. Rike-Shields2, A. Govil1, M. Cardi3, P. Brailey1, R. Alloway1, E. Woodle1

    1U Cincinnati, Cincinnati, OH, 2Surgery, U Cincinnati, Christ Hospital, Cincinnati, OH, 3Christ Hospital, Cincinnati, OH

    *Purpose: Proteasome inhibitor (PI) therapy reduces bone marrow plasma cells and HLA antibodies (Abs) in renal transplant candidates. However, rebound is common in many patients…
  • 2020 American Transplant Congress

    IL-6 Receptor Blockade But Not IL-2 Treatment Contributes to Long-Term NHP Cardiac Allograft Survival in Transient Mixed Chimeras

    K. Ahrens1, J. M. O1, W. Sommer2, J. Morrissette1, D. Becerra1, P. M. Patel1, T. Costa1, A. Dehnadi1, I. M. Hanekamp1, J. S. Allan3, G. Benichou1, J. C. Madsen4

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, 4Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Long-term tolerance of cardiac allografts has been achieved in non-human primates (NHPs) using a mixed chimerism protocol and by co-transplanting a kidney from the…
  • 2020 American Transplant Congress

    Unique Podocyte and Multiplex Single-Cell RNASeq Analysis of Paired Sera and Bone Marrow Samples Suggest a Role for Perturbed Hematopoeitic Progenitors in FSGS Recurrence

    P. Rashmi, T. Sigdel, A. Alica Da Silva, R. Paul, D. Galligan, J. Wolfe, F. Vincenti, M. Sarwal

    University of California San Francisco, San Francisco, CA

    *Purpose: Focal Segmental Glomerulosclerosis (FSGS) is the most common cause of nephrotic syndrome, can lead to ESRD, and carries a high burden of recurrence risk…
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