Articles tagged "Antigen presentation"

2015 American Transplant Congress
Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation
J. Marino,¹ P. Crosby Bertorini,¹ M. Uehara,² J. Paster,¹ S. Mordecai,³ W.-H. Liu,¹ L. Liu,¹ R. Abdi,² G. Tocco,¹ J. Kim,¹ J. Markmann,¹ G. Benichou.¹
¹Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA; ²Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA; ³Department of Pathology, Flow and Imaging Cytometry Core, Massachusetts General Hospital, Boston, MA.
We have studied the kinetics of donor cell trafficking from the graft to recipient's lymphoid organs and its correlation to the direct T cell alloresponse…
2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
T. Ueno,^1,2,3 M. Yeung,¹ M. McGrath,¹ H. Iwamoto,³ Y. Nakamura,³ O. Konnno,³ Y. Kihara,³ T. Yokoyama,³ S. Ono,³ T. Ikeda,³ S. Kawachi,³ B. Ibrahim,¹ A. Chandraker.¹
¹Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…
2015 American Transplant Congress
Impact of Serial Change of Donor Specific Antibodies On the Graft Outcomes After Liver Transplantation
D. Joo,^1,2 J. Lee,³ J. Lee,^1,2 J. Lee,^1,2 S. Kim,⁴ D. Han,^1,2 M. Ju,^1,2 J. Choi,^1,2 S. Kim,^1,2 M. Kim.^1,2
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; ³Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea; ⁴Department of Surgery, Wonju Yonsei University College of Medicine, Wonju, Korea.
Introduction: This study aimed to investigate the acute rejection rate and graft function after liver transplantation according to pre-transplantation donor specific antibody (DSA) status and…
2015 American Transplant Congress
Identification of Mouse Tolerogenic B Cells Expressing PD-L1/PD-L2 in B-1a Subset
T. Hirose,^1,2 Y. Tanaka,¹ H. Sakai,¹ Y. Sasaki,¹ H. Ohdan.¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan; ²Renal and Genitourinary Surgery, Hokkaido University, Sapporo, Hokkaido, Japan.
Donor lymphocyte infusion (DLI) has been shown to induce donor-specific hyporesponsiveness or even immune-tolerance among alloreactive T cells in different organ transplantation models. However, the…