ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antigen presentation"

  • 2018 American Transplant Congress

    Origin and Traffic of Donor-Derived Extracellular Vesicles during Allo-Sensitization

    F. Zeng,1 W. Shufesky,1 M. Yang,1 Q. Liu,1 A. Larregina,2 A. Morelli.1

    1T.E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Department of Dermatology, University of Pittsburgh, Pittsburgh, PA.

    The idea that donor dendritic cells (DCs) transplanted with the grafts and mobilized to draining lymphoid tissues (dLTs) present donor MHC molecules to allo-reactive naïve…
  • 2018 American Transplant Congress

    In Vivo Imaging and Function of Renal Tertiary Lymphoid Organs

    K. Abou-Daya, D. Zhao, A. Williams, M. Oberbarnscheidt.

    Starzl Transplantation Institute, Pittsburgh.

    Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues in the setting of chronic inflammation such as organ transplantation. The function…
  • 2018 American Transplant Congress

    Regulatory Dendritic Cell (DCreg) Cell Infusion in Living Donor Liver Transplantation

    A. Thomson, A. Humar, F. Lakkis, S. Styn, A. Zahorchak, C. Macedo, D. Metes.

    Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Purpose: We have embarked on a first-in-human phase I/II safety and preliminary efficacy trial of donor-derived regulatory dendritic cells (DCreg) in living donor liver transplantation…
  • 2018 American Transplant Congress

    Comparative Analysis of Bone Marrow versus Blood Monocyte-Derived Regulatory Dendritic Cells for Evaluation in a Miniature Swine Vascular Composite Allotransplantation Model

    T. Elgendy,1 D. Kim,2 A. Zahorchak,1 M. Ezzelarab,1 M. Solari,2 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Background: Dendritic cell therapy is a promising approach to reduced dependence on immunosuppressive drugs and for the promotion of tolerance in transplant recipients. Our aim…
  • 2018 American Transplant Congress

    Dual Function of IRF1/IRF4 on Dendritic Cells in Mouse Liver Transplantation Model

    G. Gu, T. Lu, N. Xu, Q. Xia.

    Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University School of Medicine, Shanghai, China.

    Tolerogenic dendritic cells play an essential role in transplant tolerance induction. However, how to induce tolerogenic dendritic cells is not fully understood. Here, we sorted…
  • 2017 American Transplant Congress

    Host-Derived, Intragraft Dendritic Cells Are Extensively Cross-Dressed by Donor MHC.

    A. Hughes, H. Dai, A. Williams, M. Oberbarnscheidt, A. Morelli, F. Lakkis.

    Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsbugh, PA

    Host dendritic cells (DC) are the primary driver of transplant rejection in secondary lymphoid tissues where they activate alloreactive T cells. Directly alloreactive T cells…
  • 2017 American Transplant Congress

    The Gut Microbiota Regulates Murine Cardiac Transplant Outcome.

    Y. Xiong, C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.

    UMB, Baltimore

    Background: Gut microbiota regulates systemic immunity and can activate pro- or anti-inflammatory pathways. We hypothesized that the gut microbiota influences the survival of mismatched murine…
  • 2017 American Transplant Congress

    Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.

    T. Borges, N. Murakami, L. Riella.

    Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…
  • 2017 American Transplant Congress

    Inhibition of Heat Shock Protein 90 Suppresses the Expression of MHC Class I Molecules, but Not MHC Class II Molecules, on Endothelial Cells in Allografts.

    T. Tanaka, T. Maehana, N. Masumori.

    Urology, Sapporo Medical University, Sapporo, Japan

    Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…
  • 2017 American Transplant Congress

    Expansion, Function and Clonotypic Analysis of Human Alloreactive Treg Stimulated with Different Dendritic Cell Populations or CD40L-Stimulated B Cells.

    H. Zhang,1 Y. Zhao,1 Q. Tang,3 A. Thomson.1,2

    1Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA; 3Department of Surgery, UCSF, San Francisco, CA

    Purpose:In order to establish a protocol to generate large numbers of human alloantigen-reactive regulatory T cells (arTreg) with potent allospecific suppressive capacity for therapeutic application,…
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