ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antigen presentation"

  • 2021 American Transplant Congress

    The Contribution of Disulfide-hmgb1 Released During Ischemia-reperfusion Injury to Pro-inflammatory Macrophage Polarization Following Liver Transplantation

    A. Q. Terry, R. A. Sosa, M. Rossetti, J. Nevarez-Mejia, B. V. Naini, F. Kaldas, V. Groysberg, S. Younan, R. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. Reed

    Pathology and Lab Medicine, UCLA, Los Angeles, CA

    *Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation (LT) is a pro-inflammatory response linked to poorer outcomes, including increased alloimmunity, post-LT. We previously showed that post-reperfusion…
  • 2021 American Transplant Congress

    Tissue Specific Antigen-presentation in VCA Transplantation

    B. Kern1, J. Mengwasser1, A. Reutzel-Selke1, M. I. Ashraf1, D. Polenz1, K. Fuehrer1, S. Lippert1, P. Tang1, F. Martin1, C. Witzel1, I. M. Sauer1, J. Pratschke1, S. G. Tullius2

    1Dept. of Surgery, Charité Campus CCM|CVK, Universitaetsmedizin Berlin, Germany, Berlin, Germany, 2Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    *Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…
  • 2021 American Transplant Congress

    Accelerated Bronchiolitis Obliterans After Lung Transplant Promoted by an ATG16L1 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-derived Antigen Presenting Cells

    M. Cano1, D. Zhou1, D. Kreisel1, C. Chen2, K. Pugh1, D. Byers1, R. Hachem1, A. Gelman1

    1Washington University, Saint Louis, MO, 2UT Southwestern Medical Center, Dallas, TX

    *Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood. It is…
  • 2020 American Transplant Congress

    Lymph Node Stromal Laminin Alpha5 Regulates Antigen Specific T Cell Adaptive Immunity

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, C. Paluskievicz1, J. Zhao2, R. Abdi2, J. S. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) is associated with immunity and regulates T cell entry and responses within the lymph node (LN). We hypothesized that stromal Lama5…
  • 2020 American Transplant Congress

    Role of Cross-Dressing in Kidney Transplantation

    D. Zhao, R. Tieu, K. Abou-Daya, A. Williams, M. Oberbarnscheidt, F. Lakkis

    Thomas E. Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Activation of host T cells that mediate allograft rejection is relied on dendritic cells (DCs) presenting alloantigens to T cells. Our recent study revealed…
  • 2020 American Transplant Congress

    Migration of Passenger Leukocytes During Ex Vivo Warm Perfusion

    L. Brasile1, B. Stubenitsky2

    1Research and Development, BREONICS Inc., Watervliet, NY, 2Plastic, Reconstructive & Aesthetic Surgery, St. Antonius Hospital, Utrecht, Netherlands

    *Purpose: Organ transplantation is a unique immunologic situation in which donor and recipient antigen presenting cells (APCs) are present upon reperfusion. Passenger leukocytes (PL) are…
  • 2020 American Transplant Congress

    Long-Term Allograft Survival via Donor MHC Chimerism Induced by Exosomes

    B. Gonzalez Nolasco, X. Wang, M. Wang, A. Prunevieille, K. M. Lee, J. F. Markmann, G. Benichou

    Surgery - Center for Transplantation Sciences, Massachusetts General Hospital & Harvard Medical School, Boston, MA

    *Purpose: Allogeneic transplant tolerance has been achieved by inducing mixed hematopoietic chimerism via donor bone marrow transplantation. Tolerance mechanisms in this model involve the presentation…
  • 2020 American Transplant Congress

    Xenoantibody Depletion of Human Blood with Normothermic Machine Perfusion of Porcine Kidney and Lung Prior to Liver Perfusion

    T. M. Coe1, N. Serifis1, S. Raigani1, C. Carroll1, C. G. Rickert1, R. Matheson1, D. Detelich2, W. Qin3, Y. Kan3, J. Layer3, M. Youd3, W. Westlin3, L. Yang3, A. Azimzadeh1, J. F. Markmann1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Surgery, Tufts Medical Center, Boston, MA, 3eGenesis, Cambridge, MA

    *Purpose: Genetic modifications of porcine donors for pig-to-human xenotransplantation have led to significant progress in survival of xenografts in preclinical models. Triple knock-out (TKO) of…
  • 2020 American Transplant Congress

    The Role of Galectin-1 and Basement Membrane Remodeling in Kidney Antibody-Mediated Rejection

    S. Clotet-Freixas1, C. McEvoy1, I. Batruch2, M. Kotlyar3, C. Pastrello3, J. Van1, M. Arambewela1, A. Boshart1, S. Farkona1, A. Bozovic4, V. Kulasingam4, P. Chen1, I. Jurisica3, A. Chruscinski1, R. John4, A. Konvalinka5

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, 3Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 5Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR), the leading cause of kidney graft loss, is caused by anti-HLA and non-HLA antibodies against proteins in two main kidney compartments:…
  • 2020 American Transplant Congress

    Single Cell RNA Sequencing of Murine Kidney Allografts Identifies Macrophage Gene Signature Associated with Acute Rejection

    A. Dangi1, N. Natesh2, M. Monal1, J. Wang3, X. Shen2, X. Luo1

    1Nephrology/Medicine, Duke University, Durham, NC, 2Biomedical Engineering, Duke University, Durham, NC, 3Surgery, Duke University, Durham, NC

    *Purpose: Evaluating kidney allografts using single cell RNA sequencing (scRNAseq) can provide a comprehensive qualitative and quantitative gene expression data on thousands of individual cells.…
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