Articles tagged "Antigen presentation"

2021 American Transplant Congress
Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients
M. Quante¹, J. Iske¹, D. Perkins², M. Alegre³, H. Zhou¹, A. Elkhal¹, S. G. Tullius¹
¹Department of Surgery, Brigham and Women's Hospital, Boston, MA, ²University of Illinois at Chicago, Chicago, IL, ³Department of Medicine, The University of Chicago, Chicago, IL
*Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…
2021 American Transplant Congress
The Contribution of Disulfide-hmgb1 Released During Ischemia-reperfusion Injury to Pro-inflammatory Macrophage Polarization Following Liver Transplantation
A. Q. Terry, R. A. Sosa, M. Rossetti, J. Nevarez-Mejia, B. V. Naini, F. Kaldas, V. Groysberg, S. Younan, R. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. Reed
Pathology and Lab Medicine, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation (LT) is a pro-inflammatory response linked to poorer outcomes, including increased alloimmunity, post-LT. We previously showed that post-reperfusion…
2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
B. Kern¹, J. Mengwasser¹, A. Reutzel-Selke¹, M. I. Ashraf¹, D. Polenz¹, K. Fuehrer¹, S. Lippert¹, P. Tang¹, F. Martin¹, C. Witzel¹, I. M. Sauer¹, J. Pratschke¹, S. G. Tullius²
¹Dept. of Surgery, Charité Campus CCM|CVK, Universitaetsmedizin Berlin, Germany, Berlin, Germany, ²Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…
2020 American Transplant Congress
Role of APC Subsets in Rejection and Graft-Versus-Host-Disease in Intestinal Transplantation
H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. S. Fishbein, A. Kroemer
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: Intestinal transplantation (ITx) is arguably the most immunogenic and complex organ transplantation, often accompanied with high rates of allograft rejection (AR) and graft-versus-host disease…
2020 American Transplant Congress
Influence of Microbial Communities on Transplantation
K. Janek¹, J. Fechner¹, K. Krautkramer², S. Sudakaran³, J. Denu⁴, J. Handelsman³, F. Rey⁵, E. Vivas⁵, J. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Wisconsin Institute for Discovery, Madison, WI, ⁴Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, ⁵Bacteriology, University of Wisconsin-Madison, Madison, WI
*Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
2020 American Transplant Congress
Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) regulates CD4 T cell migration and function. We hypothesized that stromal Lama5 regulates the structure of the lymph node (LN) microenvironment…
2020 American Transplant Congress
Evaluating Preformed Donor HLA Reactive T Cells Using PIRCHE-II Algorithm
T. Tomosugi¹, K. Iwasaki², S. Sakamoto¹, A. Kanda¹, K. Futamura¹, M. Okada¹, T. Hiramitsu¹, N. Goto¹, S. Narumi¹, Y. Watarai¹, T. Kobayashi², M. Niemann³, E. Spierings⁴
¹Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan, ²Kidney Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan, ³PIRCHE AG, Berlin, Germany, ⁴University Medical Center Utrecht, Utrecht, Netherlands
*Purpose: De novo donor-specific HLA antibodies (dnDSA) production involves the indirect allorecognition pathway in which recipient CD4+T cells recognize donor-HLA-derived peptide and recipient HLA class…
2020 American Transplant Congress
Accelerated Bronchiolitis Obliterans after Lung Transplant Promoted by the ATG16L1 rs2241880 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-Derived Alveolar Macrophages
M. Cano¹, D. Zhou², D. Kreisel³, C. Chen⁴, K. Pugh², D. Byers¹, R. Hachem¹, A. E. Gelman³
¹Pulmonary and Critical Care, Washington University, Saint Louis, MO, ²Surgery, Washington University, Saint Louis, MO, ³Surgery and Pathology and Immunology, Washington University, Saint Louis, MO, ⁴Pulmonary and Critical Care, Southwestern Medical Center, Dallas, TX
*Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood and require…
2020 American Transplant Congress
Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells
H. Cho¹, J. Lee², B. Kwon³, S. Park⁴, H. Park⁴, K. Yoo², K. Park², J. Kim³, S. Kang³
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ⁴Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously demonstrated that anti-CD137 agonist prevent acute graft-versus-host disease (GVHD) and chronic GVHD in the parent-into-unirradiated F1 acute or chronic GVHD model. Although…
2020 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
K. Abou Daya, D. Zhao, K. Biery, M. Oberbarnscheidt
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…