Articles tagged "Antigen presentation"

2021 American Transplant Congress
Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients
M. Quante¹, J. Iske¹, D. Perkins², M. Alegre³, H. Zhou¹, A. Elkhal¹, S. G. Tullius¹
¹Department of Surgery, Brigham and Women's Hospital, Boston, MA, ²University of Illinois at Chicago, Chicago, IL, ³Department of Medicine, The University of Chicago, Chicago, IL
*Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…
2021 American Transplant Congress
The Contribution of Disulfide-hmgb1 Released During Ischemia-reperfusion Injury to Pro-inflammatory Macrophage Polarization Following Liver Transplantation
A. Q. Terry, R. A. Sosa, M. Rossetti, J. Nevarez-Mejia, B. V. Naini, F. Kaldas, V. Groysberg, S. Younan, R. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. Reed
Pathology and Lab Medicine, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation (LT) is a pro-inflammatory response linked to poorer outcomes, including increased alloimmunity, post-LT. We previously showed that post-reperfusion…
2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
B. Kern¹, J. Mengwasser¹, A. Reutzel-Selke¹, M. I. Ashraf¹, D. Polenz¹, K. Fuehrer¹, S. Lippert¹, P. Tang¹, F. Martin¹, C. Witzel¹, I. M. Sauer¹, J. Pratschke¹, S. G. Tullius²
¹Dept. of Surgery, Charité Campus CCM|CVK, Universitaetsmedizin Berlin, Germany, Berlin, Germany, ²Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…
2020 American Transplant Congress
Pleural Exosome Mediated Donor Antigen Trafficking Into Mediastinal Lymph Nodes Represents a Novel Pathway of Recipient T Cell Activation in Lung Transplantation
A. Habertheuer¹, A. Japp², C. Ram³, S. Chatterjee⁴, S. Rostami², L. Korutla⁵, T. Ochiya⁶, A. Naji², D. Kreisel⁷, P. Vallabhajosyula⁵
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Surgery, University of Pennsylvania, Philadelphia, PA, ³New York University, New York, NY, ⁴Pathology, University of Pennsylvania, Philadelphia, PA, ⁵Surgery, Yale University, New Haven, CT, ⁶National Cancer Center Japan, Tokyo, Japan, ⁷Surgery, Washington University, St. Louis, MO
*Purpose: Studies in lung transplant models suggest that reestablishment of lymphatic continuum of pulmonary allograft via lymphangiogenesis is required for selective trafficking of donor antigen…
2020 American Transplant Congress
IL-10 Exposure Enhances IRAK-M Expression to Promote Endotoxin Tolerance and the T Cell Tolerogenic Potential of Liver Conventional DCs
Y. Zheng, R. Nakano, A. Thomson
Surgery, Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Liver conventional myeloid (m)DC contribute to liver transplant tolerance. When freshly-isolated, they produce low levels of IL-12 but high levels of IL-10 compared with…
2020 American Transplant Congress
The Role of Antigen Presentation in B Regulatory Cell Function
A. Cuenca¹, N. Feeney², K. Deng², Q. Fu², G. Huai², C. Rickert², K. Lee², J. Markmann²
¹Boston Children's Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: B regulatory cells (B regs) represent a subset of B cells with non-canonical regulatory function. The majority of effort has been focused on the…
2020 American Transplant Congress
Intra-Lymph Node Injection of Rapamycin-Alloantigen Microparticles Regulates Dendritic Cell Antigen Presentation
C. M. Paluskievicz¹, Y. Xiong¹, W. Piao¹, M. Willson-Shirkey¹, H. Eppler², C. M. Jewell², J. S. Bromberg¹
¹U Maryland, Baltimore, MD, ²U Maryland, College Park, MD
*Purpose: Microparticles (MPs) carrying peptide antigen with immune signals can be directly delivered to lymph nodes (LNs) via intra-LN injections to shape both pro-inflammatory or…
2020 American Transplant Congress
Role of APC Subsets in Rejection and Graft-Versus-Host-Disease in Intestinal Transplantation
H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. S. Fishbein, A. Kroemer
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: Intestinal transplantation (ITx) is arguably the most immunogenic and complex organ transplantation, often accompanied with high rates of allograft rejection (AR) and graft-versus-host disease…
2020 American Transplant Congress
Influence of Microbial Communities on Transplantation
K. Janek¹, J. Fechner¹, K. Krautkramer², S. Sudakaran³, J. Denu⁴, J. Handelsman³, F. Rey⁵, E. Vivas⁵, J. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Wisconsin Institute for Discovery, Madison, WI, ⁴Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, ⁵Bacteriology, University of Wisconsin-Madison, Madison, WI
*Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
2020 American Transplant Congress
Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) regulates CD4 T cell migration and function. We hypothesized that stromal Lama5 regulates the structure of the lymph node (LN) microenvironment…