ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antigen presentation"

  • 2022 American Transplant Congress

    cDC1-Mediated Prolongation of Cardiac Allograft Survival and Alloantigen Induced Transcriptional Programming

    S. L. Schroth, E. B. Thorp

    Pathology, Northwestern Feinberg School of Medicine, Chicago, IL

    *Purpose: Heart transplantation is currently the only treatment for advanced stage heart failure. While patient survival after transplantation has improved acutely, the same cannot be…
  • 2022 American Transplant Congress

    Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential

    U. Bhatia, E. C. Guinan

    Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA

    *Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…
  • 2022 American Transplant Congress

    Validation of Shared T Cell Epitope Analysis as a Tool to Detect Preformed Donor-Reactive CD4+ Memory T-helper Cells

    T. Tomosugi1, K. Iwasaki2, S. Sakamoto3, K. Ftamura1, M. Okada1, T. Hiramitsu1, N. Goto1, S. Narumi1, Y. Watarai1, T. Kobayashi4

    1Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 2Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagoya, Japan, 3Histocompatibility Laboratory, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 4Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Adaptive immunity creates immunological memory after the first response to a specific foreign antigen including HLA. During this response, adaptive immunity memorizes the molecular…
  • 2022 American Transplant Congress

    Dendritic Cell Senescence as a Key Contributor to Transplant Rejection

    J. Zhao1, X. Li1, S. Jung1, H. Zhang1, V. Kasinath1, J. Azzi1, P. Sage1, J. Bromberg2, R. Abdi1

    1Brigham and Women’s Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Intra-graft inflammation initiated by ischemia-reperfusion injury (IRI) is an unavoidable consequence of transplantation surgery and constitutes a key source of alloimmune responses. IRI leads…
  • 2021 American Transplant Congress

    Accelerated Bronchiolitis Obliterans After Lung Transplant Promoted by an ATG16L1 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-derived Antigen Presenting Cells

    M. Cano1, D. Zhou1, D. Kreisel1, C. Chen2, K. Pugh1, D. Byers1, R. Hachem1, A. Gelman1

    1Washington University, Saint Louis, MO, 2UT Southwestern Medical Center, Dallas, TX

    *Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood. It is…
  • 2021 American Transplant Congress

    A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of At-1501

    S. Perrin1, A. Gill2, C. Gill2, P. Gustafson1

    1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA

    *Purpose: Execute a phase 1 study of AT-1501 to assess safety, pharmacokinetics, and functional activity.*Methods: The study employed a placebo-controlled, sequential, dose-escalation design. 28 healthy…
  • 2021 American Transplant Congress

    Precision Medicine in Renal Transplantation: Structural Biology of HLA Defines Allelic Binding of Cardinal Pathogenic Viruses in Transplantation

    K. R. Sherwood1, A. Nguyen2, J. Tran1, O. Gunther3, A. Nellore2, R. Thompson2, J. Lan1, L. Allan1, P. A. Keown1

    1Vancouver General Hospital, Vancouver, BC, Canada, 2Biomedical Engineering, Oregon Health & Science University, Portland, OR, 3Gunther Analytics, Vancouver, BC, Canada

    *Purpose: The incidence, clearance and clinical expression of viremia post-Tx are heterogeneous, complicating prediction, prognosis and therapy. We postulated that variation viral presentation related to…
  • 2021 American Transplant Congress

    Inhibition of Fatty Acid Beta-Oxidation Prolongs Heart Allograft Survival

    B. W. Wong, Y. Zhu, H. Dun, L. Ye

    Surgery, Washington University School of Medicine, Saint Louis, MO

    *Purpose: To test the therapeutic efficacy of pharmacological inhibition of fatty acid beta-oxidation (FAO) on acute heart allograft survival.*Methods: We used a heterotopic Balb/c donor…
  • 2021 American Transplant Congress

    The Development and Characterization of AT1501, an Anti CD40L Antibody Lacking Fc Effector Function

    S. Perrin1, A. Gill2, C. Gill2, F. Vieira2, K. Thompson2, J. Lincecum2, B. Jiang2

    1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA

    *Purpose: CD40L is a costimulatory type II membrane receptor for CD40. The binding of CD40L on T helper cells to CD40 on antigen presenting cells…
  • 2021 American Transplant Congress

    DAP12 Promotes Liver DC Tolerogenicity by Negative Regulation of the CGAS-STING-IFN I Pathway

    Y. Zheng1, J. Long2, N. Ryosuke1, L. Peng3, F. Peng3, A. Thomson1

    1Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, 2Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China, 3Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China

    *Purpose: Constitutive expression of comparatively high levels of DNAX-activating protein of 12KDa (DAP12) by liver myeloid dendritic cells (mDCs) has been implicated in their immune…
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