Articles tagged "Antigen presentation"

2022 American Transplant Congress
Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells
K. Iwasaki¹, T. Tomosugi², T. Sekiya³, H. Hamana⁴, Y. Miwa¹, K. Futamura², M. Okada², T. Hiramitsu², N. Goto², S. Narumi², Y. Watarai², H. Kishi⁴, M. Okumura⁵, S. Ashimine⁵, K. Ishiyama⁵, T. Kobayashi⁵
¹Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, ²Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, ³Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, ⁴Department of Immunology, University of Toyama, Toyama, Japan, ⁵Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
*Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
2022 American Transplant Congress
Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation
S. Vasu¹, C. Darden², J. Mattke², Y. Liu³, M. C. Lawrence³, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³Baylor University Medical Center, Dallas, TX
*Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
2022 American Transplant Congress
Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation
A. Q. Terry¹, R. A. Sosa¹, F. Kaldas², R. Busuttil³, D. Gjertson¹, J. Kupiec-Weglinski¹, E. Reed¹
¹Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²University of California Los Angeles (Multi-organ), Los Angeles, CA, ³Surgery, University of California, Los Angeles, Los Angeles, CA
*Purpose: Human hepatocellular damage caused by ischemia reperfusion injury (IRI) generates the disulfide form of HMGB1 (diS HMGB1), eliciting myeloid cell activation and proinflammatory cytokine…
2022 American Transplant Congress
Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc
L. ZHANG¹, X. LI¹, J. LIU¹, H. WEI¹, C. LI¹, A. HUANG², C. ZHENG¹, Q. LIU¹
¹Department of Biochemistry, Southern University of Science and Technology, Shenzhen, China, ²Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…
2021 American Transplant Congress
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of At-1501
S. Perrin¹, A. Gill², C. Gill², P. Gustafson¹
¹Novus Therapeutics, Irvine, CA, ²ALS Therapy Development Institute, Cambridge, MA
*Purpose: Execute a phase 1 study of AT-1501 to assess safety, pharmacokinetics, and functional activity.*Methods: The study employed a placebo-controlled, sequential, dose-escalation design. 28 healthy…
2021 American Transplant Congress
Precision Medicine in Renal Transplantation: Structural Biology of HLA Defines Allelic Binding of Cardinal Pathogenic Viruses in Transplantation
K. R. Sherwood¹, A. Nguyen², J. Tran¹, O. Gunther³, A. Nellore², R. Thompson², J. Lan¹, L. Allan¹, P. A. Keown¹
¹Vancouver General Hospital, Vancouver, BC, Canada, ²Biomedical Engineering, Oregon Health & Science University, Portland, OR, ³Gunther Analytics, Vancouver, BC, Canada
*Purpose: The incidence, clearance and clinical expression of viremia post-Tx are heterogeneous, complicating prediction, prognosis and therapy. We postulated that variation viral presentation related to…
2021 American Transplant Congress
Inhibition of Fatty Acid Beta-Oxidation Prolongs Heart Allograft Survival
B. W. Wong, Y. Zhu, H. Dun, L. Ye
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: To test the therapeutic efficacy of pharmacological inhibition of fatty acid beta-oxidation (FAO) on acute heart allograft survival.*Methods: We used a heterotopic Balb/c donor…
2021 American Transplant Congress
The Development and Characterization of AT1501, an Anti CD40L Antibody Lacking Fc Effector Function
S. Perrin¹, A. Gill², C. Gill², F. Vieira², K. Thompson², J. Lincecum², B. Jiang²
¹Novus Therapeutics, Irvine, CA, ²ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory type II membrane receptor for CD40. The binding of CD40L on T helper cells to CD40 on antigen presenting cells…
2021 American Transplant Congress
DAP12 Promotes Liver DC Tolerogenicity by Negative Regulation of the CGAS-STING-IFN I Pathway
Y. Zheng¹, J. Long², N. Ryosuke¹, L. Peng³, F. Peng³, A. Thomson¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ²Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China, ³Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China
*Purpose: Constitutive expression of comparatively high levels of DNAX-activating protein of 12KDa (DAP12) by liver myeloid dendritic cells (mDCs) has been implicated in their immune…
2021 American Transplant Congress
Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients
M. Quante¹, J. Iske¹, D. Perkins², M. Alegre³, H. Zhou¹, A. Elkhal¹, S. G. Tullius¹
¹Department of Surgery, Brigham and Women's Hospital, Boston, MA, ²University of Illinois at Chicago, Chicago, IL, ³Department of Medicine, The University of Chicago, Chicago, IL
*Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…