ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antigen presentation"

  • 2022 American Transplant Congress

    cDC1-Mediated Prolongation of Cardiac Allograft Survival and Alloantigen Induced Transcriptional Programming

    S. L. Schroth, E. B. Thorp

    Pathology, Northwestern Feinberg School of Medicine, Chicago, IL

    *Purpose: Heart transplantation is currently the only treatment for advanced stage heart failure. While patient survival after transplantation has improved acutely, the same cannot be…
  • 2022 American Transplant Congress

    Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential

    U. Bhatia, E. C. Guinan

    Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA

    *Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…
  • 2022 American Transplant Congress

    Validation of Shared T Cell Epitope Analysis as a Tool to Detect Preformed Donor-Reactive CD4+ Memory T-helper Cells

    T. Tomosugi1, K. Iwasaki2, S. Sakamoto3, K. Ftamura1, M. Okada1, T. Hiramitsu1, N. Goto1, S. Narumi1, Y. Watarai1, T. Kobayashi4

    1Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 2Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagoya, Japan, 3Histocompatibility Laboratory, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 4Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Adaptive immunity creates immunological memory after the first response to a specific foreign antigen including HLA. During this response, adaptive immunity memorizes the molecular…
  • 2022 American Transplant Congress

    Dendritic Cell Senescence as a Key Contributor to Transplant Rejection

    J. Zhao1, X. Li1, S. Jung1, H. Zhang1, V. Kasinath1, J. Azzi1, P. Sage1, J. Bromberg2, R. Abdi1

    1Brigham and Women’s Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Intra-graft inflammation initiated by ischemia-reperfusion injury (IRI) is an unavoidable consequence of transplantation surgery and constitutes a key source of alloimmune responses. IRI leads…
  • 2022 American Transplant Congress

    Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells

    K. Iwasaki1, T. Tomosugi2, T. Sekiya3, H. Hamana4, Y. Miwa1, K. Futamura2, M. Okada2, T. Hiramitsu2, N. Goto2, S. Narumi2, Y. Watarai2, H. Kishi4, M. Okumura5, S. Ashimine5, K. Ishiyama5, T. Kobayashi5

    1Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, 2Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 3Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, 4Department of Immunology, University of Toyama, Toyama, Japan, 5Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
  • 2022 American Transplant Congress

    Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation

    S. Vasu1, C. Darden2, J. Mattke2, Y. Liu3, M. C. Lawrence3, B. Naziruddin1

    1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX, 3Baylor University Medical Center, Dallas, TX

    *Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
  • 2022 American Transplant Congress

    Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation

    A. Q. Terry1, R. A. Sosa1, F. Kaldas2, R. Busuttil3, D. Gjertson1, J. Kupiec-Weglinski1, E. Reed1

    1Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, 2University of California Los Angeles (Multi-organ), Los Angeles, CA, 3Surgery, University of California, Los Angeles, Los Angeles, CA

    *Purpose: Human hepatocellular damage caused by ischemia reperfusion injury (IRI) generates the disulfide form of HMGB1 (diS HMGB1), eliciting myeloid cell activation and proinflammatory cytokine…
  • 2022 American Transplant Congress

    Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc

    L. ZHANG1, X. LI1, J. LIU1, H. WEI1, C. LI1, A. HUANG2, C. ZHENG1, Q. LIU1

    1Department of Biochemistry, Southern University of Science and Technology, Shenzhen, China, 2Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…
  • 2022 American Transplant Congress

    Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells

    A. R. Gupta1, J. Wang2, C. Lareau3, I. Sun2, J. Bautista1, J. Gardner1

    1Department of Surgery, University of California San Francisco, San Francisco, CA, 2Diabetes Center, University of California San Francisco, San Francisco, CA, 3Department of Pathology, Stanford University, Stanford, CA

    *Purpose: The Autoimmune Regulator (Aire) gene, essential for central tolerance through its regulation of tissue-specific antigens in medullary thymic epithelial cells, is also expressed in…
  • 2022 American Transplant Congress

    Depletion of Donor Macrophages Permits Post-Transplant Tolerance Induction

    M. Dilts1, A. Dangi2, X. Luo3

    1Pathology, Duke University, Durham, NC, 2Medicine, Duke University, Durham, NC, 3Duke University School of Medicine, Durham, NC

    *Purpose: Using donor splenocytes fixed with cross-linker ethylcarbodiimide (ECDI-SPs), our lab has induced tolerance in a variety of murine and non-human primate models when one…
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