Articles tagged "Antigen presentation"

2022 American Transplant Congress
P2X7R Signaling Controls Exosome Release by Macrophages and Donor MHC Cross-Dressing After Skin Transplantation
H. H. Lancia¹, N. Carnel², A. G. Lellouch¹, C. Cetrulo¹, G. Benichou²
¹Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Exosomes released by transplanted organs play an important role in the host's immune response leading to their rejection. Donor exosomes contribute to alloimmunity by…
2022 American Transplant Congress
Aquaporin 4 is a Mediator of Essential Dendritic Cell Functions
M. Nicosia¹, A. M. Beavers¹, Y. Yamamoto¹, T. Thompson², T. Zindrick², A. Valujskikh¹
¹Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ²Aeromics, Cleveland, OH
*Purpose: Aquaporins are a family of transmembrane water channels implicated in a broad range of physiological functions. We previously reported that Aquaporin 4 (AQP4) is…
2022 American Transplant Congress
cDC1-Mediated Prolongation of Cardiac Allograft Survival and Alloantigen Induced Transcriptional Programming
S. L. Schroth, E. B. Thorp
Pathology, Northwestern Feinberg School of Medicine, Chicago, IL
*Purpose: Heart transplantation is currently the only treatment for advanced stage heart failure. While patient survival after transplantation has improved acutely, the same cannot be…
2022 American Transplant Congress
Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential
U. Bhatia, E. C. Guinan
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…
2022 American Transplant Congress
Validation of Shared T Cell Epitope Analysis as a Tool to Detect Preformed Donor-Reactive CD4⁺ Memory T-helper Cells
T. Tomosugi¹, K. Iwasaki², S. Sakamoto³, K. Ftamura¹, M. Okada¹, T. Hiramitsu¹, N. Goto¹, S. Narumi¹, Y. Watarai¹, T. Kobayashi⁴
¹Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, ²Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagoya, Japan, ³Histocompatibility Laboratory, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, ⁴Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
*Purpose: Adaptive immunity creates immunological memory after the first response to a specific foreign antigen including HLA. During this response, adaptive immunity memorizes the molecular…
2022 American Transplant Congress
Dendritic Cell Senescence as a Key Contributor to Transplant Rejection
J. Zhao¹, X. Li¹, S. Jung¹, H. Zhang¹, V. Kasinath¹, J. Azzi¹, P. Sage¹, J. Bromberg², R. Abdi¹
¹Brigham and Women’s Hospital, Boston, MA, ²University of Maryland School of Medicine, Baltimore, MD
*Purpose: Intra-graft inflammation initiated by ischemia-reperfusion injury (IRI) is an unavoidable consequence of transplantation surgery and constitutes a key source of alloimmune responses. IRI leads…
2022 American Transplant Congress
Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells
K. Iwasaki¹, T. Tomosugi², T. Sekiya³, H. Hamana⁴, Y. Miwa¹, K. Futamura², M. Okada², T. Hiramitsu², N. Goto², S. Narumi², Y. Watarai², H. Kishi⁴, M. Okumura⁵, S. Ashimine⁵, K. Ishiyama⁵, T. Kobayashi⁵
¹Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, ²Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, ³Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, ⁴Department of Immunology, University of Toyama, Toyama, Japan, ⁵Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
*Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
2022 American Transplant Congress
Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation
S. Vasu¹, C. Darden², J. Mattke², Y. Liu³, M. C. Lawrence³, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³Baylor University Medical Center, Dallas, TX
*Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
2022 American Transplant Congress
Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation
A. Q. Terry¹, R. A. Sosa¹, F. Kaldas², R. Busuttil³, D. Gjertson¹, J. Kupiec-Weglinski¹, E. Reed¹
¹Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²University of California Los Angeles (Multi-organ), Los Angeles, CA, ³Surgery, University of California, Los Angeles, Los Angeles, CA
*Purpose: Human hepatocellular damage caused by ischemia reperfusion injury (IRI) generates the disulfide form of HMGB1 (diS HMGB1), eliciting myeloid cell activation and proinflammatory cytokine…
2022 American Transplant Congress
Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc
L. ZHANG¹, X. LI¹, J. LIU¹, H. WEI¹, C. LI¹, A. HUANG², C. ZHENG¹, Q. LIU¹
¹Department of Biochemistry, Southern University of Science and Technology, Shenzhen, China, ²Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…

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