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Articles tagged "Anticoagulation"

  • 2018 American Transplant Congress

    Hemodialysis Catheter-Related Right Atrial Thrombus Detected Prior to Kidney Transplantation

    S. Jeung, H. Kim, C. Baek, S-.K. Park.

    Internal Medicine, Division of Nephrology, Asan Medical Center, Seoul, Republic of Korea.

    Study's purposeThe study was conducted to review the clinical characteristics, management, and outcomes of patients with hemodialysis catheter-related right atrial thrombus (RAT) detected prior to…
  • 2018 American Transplant Congress

    The Effect of Perioperative Antiplatelet/Anticoagulant Therapy on the Incidence of Early Postoperative Thromboembolic Complications and Bleeding in Kidney Transplantation – A Dual Center Retrospective Cohort Study of 2000 Kidney Transplant Recipients

    T. van den Berg,1 R. Minnee,2 G. Nieuwenhuijs-Moeke,3 S. Bakker,4 R. Pol.1

    1Department of Surgery, University Medical Center Groningen (UMCG), Groningen, Netherlands; 2Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands; 3Department of Anesthesiology, UMCG, Groningen, Netherlands; 4Department of Internal Medicine-Nephrology, UMCG, Groningen, Netherlands.

    Thromboembolic complications (TECs) are dreaded complications after kidney transplantation (KTx). Consequences are severe and can result in delayed graft function or even graft loss. Perioperative…
  • 2018 American Transplant Congress

    Anticoagulation in Pediatric Liver Transplantation; the Pros and Cons

    M. Werner,1 R. de Kleine,1 M. de Boer,1 V. de Meijer,1 R. Scheenstra,2 H-.J. Verkade,2 F. Bodewes,2 S. Bontemps,3 T. Lisman,1 R. Porte.1

    1HPB Surgery & Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; 2Pediatric Gastroenterology & Hepatology, University Medical Center Groningen, Groningen, Netherlands; 3Pediatric Intensive Care, University Medical Center Groningen, Groningen, Netherlands.

    Background: Hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) are serious causes of morbidity and mortality after pediatric orthotopic liver transplantation (OLT). To minimize…
  • 2018 American Transplant Congress

    Brain Death Conditions Intensify Inflammation and Impair Metabolic Gene Expression

    L. Zitur, P. Chlebeck, S. Odorico, T. Zens, J. Danobeitia, M. Eerhart, J. Reyes, A. D'Alessandro, K. Brunner, S. Capuano, L. Fernandez.

    University of Wisconsin, Madison.

    Rationale: Inflammation observed in Brain Death (BD) donors is linked to reduced graft function and survival compared to living donors (LD). Detailed analyses of non-human…
  • 2017 American Transplant Congress

    Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonlad,1 H. Xu,1 R. Smith,3 S. Sacks,3 A. Dorling,3 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas's NHS Foundation Trust, Sondon, United Kingdom; 3MRC Centre for Transplantation, London, United Kingdom

    Introduction:Thrombotic microangiopathy (TMA) is a phenomenon observed in antibody-mediated rejection (AMR) of the kidney transplant, particularly in highly sensitized individuals. Following promising data in a…
  • 2017 American Transplant Congress

    Nucleic Acid Scavenging Microfiber Mesh Inhibits Trauma Induced Inflammation and Thrombosis After Organ Transplantation.

    J. Kwun,1 J. Lee,1 J. Jackman,2 M. Manook,1 E. Elster,3 A. Kirk,1 B. Sullenger.1

    1Surgery, Duke University, Durham, NC; 2Biomedical Engineering, Duke University, Durham, NC; 3Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD

    [Introduction] Trauma patients produce a host of danger signals and high levels of damage-associated molecular patterns (DAMPs) after cellular injury and tissue damage. Organs from…
  • 2017 American Transplant Congress

    Role of Protease Activated Receptor 1 and Sphingosine-1-Phospate Receptor 1 in Mice Hepatic Ischemia-Reperfusion Injury for Targeting Cell Signal Pathways of Activated Protein C.

    T. Ito, N. Kuriyama, H. Kato, Y. Iizawa, A. Tanemura, Y. Murata, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji.

    Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan

    Introduction: Hepatic ischemia-reperfusion injury (IRI) is a serious comlication during liver surgery. As for therapeutic strategies on hepatic IRI, we previously demonstrated that activated protein…
  • 2017 American Transplant Congress

    Risk of Venous Thromboembolism After Lung Transplant.

    R. Felkner,1 A. Condon,2 K. Rolling,3 M. Hayney.3

    1William S. Middleton Memorial Veterans Hospital, Madison, WI; 2UW Health, Madison, WI; 3University of Wisconsin School of Pharmacy, Madison, WI

    PurposeVenous thromboembolism (VTE) is a significant cause of morbidity and mortality following lung transplantation. The purpose of this study was to describe the incidence of…
  • 2017 American Transplant Congress

    Coagulation Pathway Perturbations Associated with Pig-to-Baboon Lung Xenotransplantation.

    S. Sendil, B. French, O. Siddiqui, D. Parsell, C. Laird, A. Cimeno, S. Dahi, L. Burdorf, A. Azimzadeh, R. Pierson III.

    Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD

    Aim Dysregulation of coagulation is associated with graft failure in multiple xenotransplantation models. This study describes thromboelastographic profiles in baboon recipients of a genetically engineered…
  • 2017 American Transplant Congress

    Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonald,1 H. Xu,1 R. Smith,3 A. Dorling,3 A. Kirk,1 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas'NHS Foundation Trust, London, United Kingdom; 3MRC Centre for Transplantation, King's College, London, United Kingdom

    Introduction: Early activation of coagulation and complement are important factors in the initiation of instant blood mediated inflammation (IBMIR) in xenoislet models. Two novel 'cytotopic'…
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