ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Anticoagulation"

  • 2018 American Transplant Congress

    The Impact of Anticoagulation Therapy Modifications during the Index Hospitalization on Clinical Outcomes in Kidney Transplant Recipients

    J. Hardcopf, H. Meadows, N. Pilch, C. Perez, N. Patel, J. Fleming, H. Corbo, T. Harrison, B. O'Brien, D. DuBay, P. Baliga, D. Taber.

    Medical University of South Carolina, Charleston, SC.

    Background: The aim of this study was to determine whether changing anticoagulation medications during the index admission for kidney transplant (KT) is significantly associated with…
  • 2018 American Transplant Congress

    Direct Oral Anticoagulation Use in Kidney Transplant Recipients

    S. Shaikh,1 M. Samaniego,2 J. Park.2

    1MedStar Georgetown University Hospital, Washington DC; 2Michigan Medicine, Ann Arbor, MI.

    Objective: There is a lack of high-level evidence identifying meaningful outcomes with direct oral anticoagulants (DOACs) in kidney transplant recipients. The primary objective of this…
  • 2018 American Transplant Congress

    Recent Exposure to Four-Factor Prothrombin Complex Concentrate (4F-PCC) is Associated with Intracardiac Thrombus during Liver Transplantation

    M. Misel,1,2 G. Schnickel,1 J. Berumen,1 R. Sanchez,3 K. Mekeel.1

    1Division of Transplant & Hepatobiliary Surgery, UC San Diego Health, La Jolla, CA; 2Pharmacy Inpatient Services, UC San Diego Health, La Jolla, CA; 3Anesthesiology, UC San Diego Health, La Jolla, CA.

    BackgroundPatients with ESLD often have imbalance in hemostasis & monitoring traditional coagulation lab markers are generally not helpful. Intracardiac thrombus (ICT) during liver transplant (LT)…
  • 2018 American Transplant Congress

    Hemodialysis Catheter-Related Right Atrial Thrombus Detected Prior to Kidney Transplantation

    S. Jeung, H. Kim, C. Baek, S-.K. Park.

    Internal Medicine, Division of Nephrology, Asan Medical Center, Seoul, Republic of Korea.

    Study's purposeThe study was conducted to review the clinical characteristics, management, and outcomes of patients with hemodialysis catheter-related right atrial thrombus (RAT) detected prior to…
  • 2017 American Transplant Congress

    Coagulation Pathway Perturbations Associated with Pig-to-Baboon Lung Xenotransplantation.

    S. Sendil, B. French, O. Siddiqui, D. Parsell, C. Laird, A. Cimeno, S. Dahi, L. Burdorf, A. Azimzadeh, R. Pierson III.

    Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD

    Aim Dysregulation of coagulation is associated with graft failure in multiple xenotransplantation models. This study describes thromboelastographic profiles in baboon recipients of a genetically engineered…
  • 2017 American Transplant Congress

    Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonald,1 H. Xu,1 R. Smith,3 A. Dorling,3 A. Kirk,1 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas'NHS Foundation Trust, London, United Kingdom; 3MRC Centre for Transplantation, King's College, London, United Kingdom

    Introduction: Early activation of coagulation and complement are important factors in the initiation of instant blood mediated inflammation (IBMIR) in xenoislet models. Two novel 'cytotopic'…
  • 2017 American Transplant Congress

    Risk of Major Bleeding in Solid Organ Transplant Recipients Taking Calcineurin Inhibitors Concomitantly with Direct Oral Anticoagulants Compared to Warfarin.

    J. Hazelcorn, R. Yau, N. Sabagha, M. Moaddab, M. Manson.

    Pharmacy, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Houston, TX

    Purpose: Direct oral anticoagulants (DOAC) and calcineurin inhibitors (CNI) are both substrates of CYP 3A metabolism; therefore, the purpose of this study is to assess…
  • 2017 American Transplant Congress

    Simultaneous Pancreas-Kidney Transplantation Can Be Safely Done on Dabigatran Therapy.

    W. Lisik,1 A. Jozwik,1 J. Czerwinski,2 L. Gorski,1 M. Kosieradzki.1

    1Department of General and Transplantation Surgery, The Medical University of Warsaw, Warsaw, Poland; 2Department of Surgical and Transplant Nursing, The Medical University of Warsaw, Warsaw, Poland

    Due to convenient application, novel oral anticoagulants (NOAC), although not registered for renal failure, are an attractive therapeutic option. They are even more tempting in…
  • 2017 American Transplant Congress

    Cytotopic Thrombin Inhibition Prior to Cold Ischaemia Attenuates Microvascular Endothelial Ischaemia-Reperfusion Injury.

    B. Sandhu,1 M. Prendecki,1 J. Crawley,1 N. Galloway-Phillips,1 N. Vallant,1 J. Mason,1 A. Dorling,2 R. Smith,2 C. Pusey,1 V. Papalois.1

    1Imperial College, London, United Kingdom; 2King's College, London, United Kingdom

    Purpose: Microvascular dysfunction post-reperfusion of the ischaemic endothelium manifests as cellular necrosis and enhanced endothelial permeability. Thrombin generation post-reperfusion of the ischaemic endothelium may be…
  • 2017 American Transplant Congress

    Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonlad,1 H. Xu,1 R. Smith,3 S. Sacks,3 A. Dorling,3 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas's NHS Foundation Trust, Sondon, United Kingdom; 3MRC Centre for Transplantation, London, United Kingdom

    Introduction:Thrombotic microangiopathy (TMA) is a phenomenon observed in antibody-mediated rejection (AMR) of the kidney transplant, particularly in highly sensitized individuals. Following promising data in a…
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