ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antibodies"

  • 2022 American Transplant Congress

    Effects of Race, Previous CoV2 Exposure and the Length and Type of Maintenance Immunosuppression on Protective Immunity to COVID19 Vaccine in Solid Organ Transplant Recipients

    A. Choudhary1, M. Lerman2, S. Khan2, J. Hunt2, A. Nikaein3, D. Calianese1, E. Kalu2, D. K. Jaijyan4, W. Honnen1, A. Pinter1

    1PHRI, Rutgers University, Newark, NJ, 2Transplant, Medical City Dallas, Dallas, TX, 3Texas Speciality, Medical City Dallas, Dallas, TX, 4pHRI, Rutgers University, Newark, NJ

    *Purpose: The diverse factors affecting the vaccine induced neutralizing antibody response in solid organ transplant recipients and their immunity against CoV2 variants are needed to…
  • 2022 American Transplant Congress

    Natural Antibodies Are Associated With Rejection And Long-term Renal Allograft Loss In A Multi-center International Cohort

    S. B. See1, X. Yang2, C. Burger3, B. Lamarthée4, R. Snanoudj5, R. Shihab1, D. S. Tsapepas6, P. Roy1, S. Larivière-Beaudoin7, K. Hamelin7, A. Mendoza Rojas8, N. M. van Besouw8, A. Bartosic9, N. Daniel9, E. R. Vasilescu10, S. Mohan11, D. Cohen11, L. Ratner11, C. C. Baan8, J. S. Bromberg9, H. Cardinal7, D. Anglicheau3, Y. Sun2, E. Zorn1

    1CCTI, Columbia University Irving Medical Center, New York, NY, 2Biostatistics, Columbia University Irving Medical Center, New York, NY, 3Necker Hospital, Paris, France, 4Necker-Enfants Malades Institute, Paris, France, 5Bicêtre Hospital, Paris, France, 6Surgery, Columbia University Irving Medical Center, New York, NY, 7CHUM, Montreal, QC, Canada, 8Erasmus MC, Rotterdam, Netherlands, 9Surgery, University of Maryland School of Medicine, Baltimore, MD, 10Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 11Medicine, Columbia University Irving Medical Center, New York, NY

    *Purpose: Potentially harmful non-donor-specific human leukocyte antigen antibodies have been identified in renal transplantation, including natural IgG antibodies (Nabs) reactive to varied antigenic structures.*Methods: In…
  • 2022 American Transplant Congress

    Transplant Patients Risk for SARS-CoV-2 Infection Post-2nd Vaccine Dose; We Are Not Home and Dry Yet

    G. Koimtzis1, L. Szabó1, P. Nagaraja1, C. Chalklin1, D. Elker2, A. Asderakis1

    1Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, 2Cardiff Transplant Unit, University Hosptal of Wales, Cardiff, United Kingdom

    *Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. Data of transplant patients’ infections post-2nd vaccine dose is not available. The aim of the…
  • 2022 American Transplant Congress

    HLA-DR/DQ Single Molecule Eplet Mismatch and Formation of De Novo Donor-Specific Anti-HLA Antibodies After Kidney Transplantation in Children

    V. K. Sigurjonsdottir1, K. Piburn1, P. C. Grimm1, B. M. Zhang2

    1Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, 2Histocompatibility and Immunogenetics Laboratory, Stanford Blood Center, Palo Alto, CA

    *Purpose: The advances in HLA typing methods and elucidation of three-dimensional molecular structures of HLA antigens in recent years have allowed analysis of donor/recipient HLA…
  • 2022 American Transplant Congress

    An Analysis of Serological Response and Infection Outcomes Following Oxford Astra-Zeneca (azd1222) and Pfizer-Biontech (mRNA BNT162b2) SARS-CoV-2 Vaccines in Kidney and Pancreas Transplant Patients

    A. Asderakis1, U. Khalid1, G. Koimtzis1, M. Ponsford2, L. Szabó1, L. Grant2, S. Jolles2, I. Humphreys3

    1Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, 2Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom, 3Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom

    *Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. This study aims to compare the humoral responses between the Oxford-Astra-Zeneca(AZ) and BNT162b2(Pfizer-BioNTech) vaccines in…
  • 2022 American Transplant Congress

    Antibody Response to Sars-CoV-2 Vaccine Among Kidney Transplant Recipients: A Retrospective Cohort Study

    H. Ishida1, K. Unagami2, K. Ishii3, T. Kanzawa2, T. Yagisawa4, K. Tanabe2, M. Furusawa2

    1Tokyo Women's, Tokyo, Japan, 2Tokyo Women's Medical University, Tokyo, Japan, 3Tokyo Wimen's Medical University, Tokyo, Japan, 4Department of Urology, Tokyo Women's Medical University, Tokyo, Japan

    *Purpose: We examined a positivity of corona virus antibody in kidney transplant recipients who received two-doses BNT162B2 (mRNA) vaccination during the beginning 6 months in…
  • 2022 American Transplant Congress

    Circulating Antibodies in CMV Viremia in Kidney Transplantation

    T. Sigdel1, P. Velpurisiva1, V. Dharnidharka2, M. M. Sarwal1

    1UCSF, San Francisco, CA, 2Washington University in St. Louis, Saint Louis, MO

    *Purpose: Role of circulating antibodies (Abs) in graft injury outcomes of kidney transplant is reported by us and others. Cytomegalovirus (CMV) is known to contribute…
  • 2022 American Transplant Congress

    Antibody Responses to an Additional Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients with and without HIV

    M. Saksena1, G. Carrara2, B. Haydel2, A. Azad1, K. Srivastava1, C. Gleason1, K. Beach1, L. Sominsky1, A. Oostenink1, G. Cai1, J. Carreno Quiroz1, G. Singh1, S. Florman2, C. Cordon-Cardo3, J. Aberg4, A. Wajnberg5, F. Krammer1, V. Simon1, M. Rana4

    1Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, 3Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 4Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 5General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Solid organ transplant (SOT) recipients mount suboptimal immune responses to a two-dose SARS-CoV-2 mRNA vaccine series. Data regarding antibody responses in HIV and SOT…
  • 2021 American Transplant Congress

    Outcomes of IVIG Monotherapy for Donor-Specific Antibodies After Lung Transplantation

    K. Spence, S. Heeney, M. Morrison, S. A. Rega, F. D. Irene, K. B. Harrison, C. M. Shaver

    Vanderbilt University Medical Center, Nashville, TN

    *Purpose: De novo donor-specific antibodies (DSA) are a risk factor for antibody mediated rejection (AMR) and poor clinical outcomes after lung transplant (LT). Intravenous immune…
  • 2021 American Transplant Congress

    Nomogram of Quantity of Peripheral Cxcr5+Cd8+ T Cells, Aims to Predict Risk of De Novo Dsa in First-time Kidney Transplant Recipients

    J. Zimmerer1, M. Abdel-Rasoul2, G. Bumgardner1

    1OSU, Columbus, OH, 2Center for Biostatistics, OSU, Columbus, OH

    *Purpose: We recently reported that peripheral CXCR5+CD8+ T cells are inversely associated with the risk of developing de novo DSA (dnDSA) in the first year…
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