2022 American Transplant Congress
TIM-4 Identifies Proinflammatory B Cells Expressing an IL-23-Driven “Proinflammatory Module”
1University of Pittsburgh, Pittsburgh, PA, 2Thomas E Starzl Transplant Institute, Pittsburgh, PA
*Purpose: B cells play important Ab-independent roles promoting or inhibiting immune responses through the opposing activity of Bregs and poorly understood effector B cells (Beff)…2022 American Transplant Congress
Non-HLA Autoantibodies: The Hidden Offenders to Double the Trouble
*Purpose: There is emerging evidence suggesting non-HLA autoantibodies triggered after the graft injury. Here, we report 3 cases where non-HLA autoantibodies were positive after 3…2022 American Transplant Congress
Use of De Novo mTOR Inhibitors in Highly Sensitized Kidney Transplant Recipients
*Purpose: mTOR inhibitors (mTORi) allow calcineurin-inhibitor reduction without loss of efficacy and may improve allograft-transplant outcomes. However, the safety of this protocol in high-immunological risk…2022 American Transplant Congress
Presence of AT1R Antibody Pre-Transplant Does Not Correlate with Rejection in a Large Pediatric Kidney Transplant Cohort
*Purpose: Describe correlations between pre-transplant (PreTXP) presence of anti-angiotensin II receptor type 1 antibodies (AT1RAb) and post-transplant (PostTXP) outcomes in a pediatric kidney transplant (PKT)…2022 American Transplant Congress
Significance of C4d Expression in Peritubular Capillary Concurrent with Microvascular Inflammation in For-Cause Biopsies of ABO-Incompatible Renal Allografts
*Purpose: ABO incompatible (ABOi) kidney transplantation (KT) has been increasing due to severe organ shortages. Pathologic diagnosis of antibody-mediated rejection (ABMR) in ABOi patients is…2022 American Transplant Congress
B Cells Fit for Germinal Center Activity Predict Response to a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
*Purpose: While SARS-CoV-2 vaccination has dramatically reduced COVID-19 severity in the general population, fully vaccinated solid organ transplant recipients (SOTRs) demonstrate reduced seroconversion and increased…2022 American Transplant Congress
Characterization Of Local Antibody Responses In Human Cardiac Allograft Vasculopathy
*Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of heart graft recipient mortality after five years post-transplant. A major hurdle to improving outcomes is…2022 American Transplant Congress
Six-Month Antibody Kinetics and Durability After Three Doses of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
1Johns Hopkins, Baltimore, MD, 2University of Wisconsin, Madison, WI
*Purpose: Some solid-organ transplant recipients (SOTRs) with low or negative antibody levels after a 2-dose mRNA vaccine series against SARS-CoV-2 experience boosting after a third…2022 American Transplant Congress
Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Practice Patterns, Report from the Paramour “Pediatric Renal AMR Outcomes” Study
*Purpose: There is insufficient data on children with AMR in the literature, and the optimal therapy for AMR is not well defined. We aim to…2022 American Transplant Congress
Obinutuzumab in Kidney Transplantation: Effect on B-cell Counts and Crossmatch Tests
*Purpose: Resistance to the action of rituximab (RTX), has been documented in several diseases. More recently, obinutuzumab (OBZ) has shown promise where RTX has failed…
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