Articles tagged "Antibodies"

2015 American Transplant Congress
Improving ABMR Diagnostics Through Advanced Anti-HLA Antibody Screening Techniques
R. Ponsirenas,^1,2 H. Cazarote,^1,2 S. Shimakura,³ J. Valdameri,¹ F. Contieri,⁴ C. von Glehn,^1,2 M. Susin.^1,2
¹Transplant Immunology Laboratory, Pontifícia Universidade Católica do Paraná, Curitiba, Parana, Brazil; ²Medicine School, Pontifícia Universidade Católica do Paraná, Curitiba, Parana, Brazil; ³Departament of Statistics, Universidade Federal do Parana, Curitiba, Parana, Brazil; ⁴Kidney Transplant Unit, Hospital Evangélico de Curitiba, Curitiba, Parana, Brazil.
The identification of low-level antibodies by single antigen bead methodology has brought advancements in risk evaluation of kidney transplants recipients. However, the use of the…
2015 American Transplant Congress
Microvascular (MIA) and Interstitial (i) Inflammation Influence Late Death-Censored Graft Failure (DCGF) After Kidney Transplantation
R. Gaston,¹ A. Fieberg,² R. Leduc,² J. Connett,² F. Cosio,³ S. Gourishankar,⁴ J. Grande,³ L. Hunsicker,⁵ B. Kasiske,⁶ J. Cecka,⁷ A. Matas,² D. Rush.⁸
¹UAB, Birmingham; ²U Minnesota, Minneapolis; ³Mayo Clinic, Rochester; ⁴U Alberta, Edmonton, Canada; ⁵U Iowa, Iowa City; ⁶Hennepin County Med Ctr, Minneapolis; ⁷UCLA Immunogenetics, Los Angeles; ⁸U Manitoba, Winnipeg, Canada.
We and others have shown late DCGF is due to ongoing, most often immune, injury. Though there is general agreement that antibody-mediated injury is a…
2015 American Transplant Congress
Rituximab With Intravenous Immune Globulin in Sensitized Patients Awaiting Heart Transplant: Does It Work?
J. Patel, N. Reinsmoen, M. Kittleson, A. Velleca, D. Dilibero, F. Liou, D. Chang, A. Hage, L. Czer, F. Esmailian, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Highly sensitized heart transplant (HTx) recipients with donor specific antibodies (DSA) are at increased risk of rejection and death. Rituximab with Intravenous Immune Globulin…
2015 American Transplant Congress
Variables Related to the Development of Donor Specific Antibodies (DSA) Post-Kidney Transplant (KTx): Implications for Late Graft Histology and Survival
F. Cosio,¹ C. Schinstock,¹ M. Stegall.²
¹Medicine, Mayo Clinic, Rochester, MN; ²Surgery, Mayo Clinic, Rochester, MN.
Introduction. The incidence of de novo DSA increases post-KTx. DSA is associated to reduced graft survival likely due to chronic antibody mediated rejection (cAMR). However,…
2015 American Transplant Congress
BAFF Binding to T Cell-Expressed BAFF-R Promotes Follicular Helper T Cell Proliferation and GC B Cell Responses
M. Chen,¹ Q. Li,¹ W. Stohl,² S. Zheng,² X. He,¹ Z. Guo.¹
¹Organ Transplant Center, 1st affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Division of Rheumatology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF) in promoting germinal center (GC) responses in mouse…
2015 American Transplant Congress
Serum Creatinine Is Most Predictive of Graft Loss in Late Antibody Mediated Rejection
G. Agarwal, D. Diskin, R. Reed, J. Locke, V. Kumar.
Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
Development of acute antibody mediated rejection (AMR) is associated with graft loss and can occur both early (< 3 months) and late (> 3 months)…
2015 American Transplant Congress
Interstitial Fibrosis Is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy
D. Toki,¹ H. Ishida,¹ M. Okumi,¹ T. Shimizu,¹ H. Shirakawa,¹ M. Inui,¹ K. Omoto,¹ K. Unagami,¹ T. Kanzawa,¹ K. Honda,² J. Koike,³ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Pathology, Tama Hospital, Kanagawa, Japan.
PURPOSE: Transplant glomerulopathy (TGP) represents chronic antibody-mediated injury in the glomerular capillaries after renal transplantation, and is the main cause of graft failure. TGP is…
2015 American Transplant Congress
Impact of Serial Change of Donor Specific Antibodies On the Graft Outcomes After Liver Transplantation
D. Joo,^1,2 J. Lee,³ J. Lee,^1,2 J. Lee,^1,2 S. Kim,⁴ D. Han,^1,2 M. Ju,^1,2 J. Choi,^1,2 S. Kim,^1,2 M. Kim.^1,2
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; ³Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea; ⁴Department of Surgery, Wonju Yonsei University College of Medicine, Wonju, Korea.
Introduction: This study aimed to investigate the acute rejection rate and graft function after liver transplantation according to pre-transplantation donor specific antibody (DSA) status and…
2015 American Transplant Congress
Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function
A. Gilbert,¹ E. Hall,¹ O. Timofeeva,² M. Awwad,² M. Grafals,¹ P. Weems,¹ D. Li,² S. Rosen-Bronson,² J. Moore,¹ B. Javaid,¹ M. Cooper.¹
¹Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; ²Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.
Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
2015 American Transplant Congress
Outcomes of Kidney Transplantation of ABO- and Crossmatch-Incompatible Recipient-Donor Pairs Entered in Kidney Paired Donation Program
D. Dadhania, M. Charlton, M. Aull, R. Friedlander, T. Muthukumar, J. Lee, M. Goris, D. Serur, S. Kapur, V. Sharma.
Transplantation Medicine, Weill Cornell Medical Center, New York, NY.
Kidney Paired Donation (KPD) enables ABO-incompatible (ABOI) and crossmatch-incompatible (XMI) patients to undergo transplantation using a 'more compatible' donor. Identification of factors that predict early…