Articles tagged "Antibodies"

2015 American Transplant Congress
Transplant Glomerulopathy in a Novel Model of Chronic Antibody Mediated Rejection Is Associated With DSA and Glomerular IgM
S. Panzer,¹ S. Reese,¹ N. Wilson Schlei,¹ W. Zhong,² A. Djamali.¹
¹Medicine, University of Wisconsin Madison, Madison, WI; ²Pathology, University of Wisconsin Madison, Madison, WI.
PurposeChronic active antibody mediated rejection (cAMR) and transplant glomerulopathy (TG) are major determinants of long-term allograft survival. However, the contribution of DSA and glomerular immunoglobulins…
2015 American Transplant Congress
Tolerance to Graft A-Antigens Following ABO-Incompatible Heart Transplantation (HTx) in a Blood Group A-Transgenic Mouse Model
B. Motyka,¹ K. Labonte,¹ F. Rahman,¹ J. Pearcey,¹ K. Tao,¹ M. Mengel,¹ B. Sis,¹ P. Cowan,² L. West.¹
¹Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada; ²Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia.
Purpose: ABOi HTx can be performed safely in infants when ABO antibody (Ab) levels are low or absent. Following ABOi HTx, immune tolerance develops to…
2015 American Transplant Congress
Outcomes Following Kidney Transplant With Low Level Positive Flow Cytometric Crossmatch
C. Schinstock, F. Cosio, M. Gandhi, L. Cornell, M. Stegall.
Mayo Clinic, Rochester, MN.
Introduction: Highly-sensitized kidney transplant (KTx) candidates have difficulty finding a negative crossmatch donor. KTx with low level positive crossmatch might be the next best option.…
2015 American Transplant Congress
Novel Flow Cytometry Method for Detecting Complement-Fixing Blood Group IgG Antibody in ABO-Incompatible Renal Transplantation
T. Ishizuka,¹ M. Yasuo,¹ Y. Ishida,¹ H. Miura,¹ K. Iwadoh,² T. Murakami,² K. Kitajima,² I. Nakajima,² S. Fuchinoue.²
¹Transplant Immunology, Tokyo Women's Medical University, Shinjuku ward, Tokyo, Japan; ²Surgery III, Tokyo Women's Medical University, Shinjuku ward, Tokyo, Japan.
【Background】We experienced a hyperacute rejection (HAR) in ABO-incompatible renal transplantation (ABO-I RTx) on POD 0. We hypothesized that complement-fixing IgG anti-A/B blood group antibody (anti-A/B…
2015 American Transplant Congress
T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques
C. Burghuber,^1,2 J. Kwun,¹ E. Page,¹ F. Leopardi,³ A. Gibby,¹ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.¹
¹Emory University, Atlanta, GA; ²Medical University Vienna, Vienna, Austria; ³Duke University, Durham, NC.
[Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…
2015 American Transplant Congress
B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Response After Transplantation
J. Marino, P. Crosby Bertorini, J. Paster, A. Trowell, K. Briggs, L. Maxwell, G. Benichou.
Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA.
Pre-transplant B cell depletion in NHP with Rituximab (IgG1 anti-CD20 mAb) combined with cyclosporin A has been shown to promote the survival of islets allografts.…
2015 American Transplant Congress
Immune Response to Kidney and Pancreas Self-Antigens Are Associated With Antibody Mediated Rejection in Simultaneous Kidney Pancreas Transplants
M. Gunasekaran,¹ A. Siddiq,² S. Shenoy,¹ J. Wellen,¹ T. Mohanakumar.¹
¹Surgery, Washington Univ Sch of Med, St. Louis, MO; ²Medicine, Washington Univ Sch of Med, St. Louis, MO.
Background: Simultaneous kidney-pancreas transplantation (SKP Tx) is performed as treatment option for type-1 diabetes with end stage kidney diseases. Though allograft survival was improved with…
2015 American Transplant Congress
Immune-Mediated Injury in Kidney Transplant Recipients Treated With Alemtuzumab Induction and a Steroid Avoidance Protocol
R. Sapir-Pichhadze, T. Mahbub, C. Saw, D. Baran.
McGill University Health Centre, Montreal, Canada.
Study purpose: We evaluated short-term clinical and immunological outcomes of kidney transplant recipients who received alemtuzumab induction and a steroid-avoidance protocol.Methods: This is a retrospective…
2015 American Transplant Congress
Efficacy of Rituximab Sparing Protocol for ABO Incompatible Renal Transplant in Patients With Low Titers
S. Narumi,¹ Y. Watarai,¹ N. Goto,¹ T. Hiramitsu,¹ T. Yamamoto,¹ M. Tsujita,¹ M. Okada,¹ K. Futamura,¹ A. Takeda,² T. Kobayashi.³
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan; ²Nephrology, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan; ³Applied Immunology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
[Introduction]Acute antibody mediated rejection (AMR) has been a major problem in ABO-incompatible kidney transplantation (ABOi-KTx), and currently mycophenolate mofetil and rituximab have been used to…
2015 American Transplant Congress
Inhibition of Endogenous Memory CD8 T Cell Infiltration Into Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage Is Required to Promote Long-Term Graft Survival
N. Kohei,¹ H. Tsuda,^1,3 T. Tanaka,^1,4 S. Iida,² T. Abe,³ C. Su,¹ D. Kish,¹ K. Tanabe,² A. Valujskikh,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology Kidney Center, Tokyo Women's Medical University, Tokyo, Japan; ³Urology, Osaka University, Osaka, Japan; ⁴Urology, Sapporo Medical University, Sapporo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…