ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antibodies"

  • 2015 American Transplant Congress

    A Novel DSA Flow Cytometer Crossmatch (DSA-FXM) to Eliminate Ambiguous Auto- and Allo-FXM Results

    G. Chen, L. Lin, D. Tyan.

    Pathology, Stanford University, Palo Alto, CA.

    Introduction:Though usually rejected on theoretical grounds, a positive Auto-FXM could result from either or both auto-reactive non-HLA or HLA-antibodies (Ab). Furthermore, a positive Auto-FXM serum…
  • 2015 American Transplant Congress

    DSA Detected by ELISA-PRA Is Associated With High Risk for Development of AMR in Stable Kidney Transplant Recipients

    D. Lee,1 J. Kim,2 B. Kim,3 M. Chun,4 I. Kim.5

    1Medicine, Division of Nephrology, Maryknoll General Hospital, Busan, Republic of Korea; 2Surgery, Maryknoll General Hospital, Busan, Republic of Korea; 3Laboratory Medicine, Maryknoll General Hospital, Busan, Republic of Korea; 4Pathology, Maryknoll General Hospital, Busan, Republic of Korea; 5Urology, Maryknoll General Hospital, Busan, Republic of Korea.

    Background: Donor specific anti-HLA antibodies (DSA) are a major cause of antibody mediated rejection (AMR) and allograft loss, determining how to monitor patients for DSA…
  • 2015 American Transplant Congress

    Transplant Glomerulopathy in a Novel Model of Chronic Antibody Mediated Rejection Is Associated With DSA and Glomerular IgM

    S. Panzer,1 S. Reese,1 N. Wilson Schlei,1 W. Zhong,2 A. Djamali.1

    1Medicine, University of Wisconsin Madison, Madison, WI; 2Pathology, University of Wisconsin Madison, Madison, WI.

    PurposeChronic active antibody mediated rejection (cAMR) and transplant glomerulopathy (TG) are major determinants of long-term allograft survival. However, the contribution of DSA and glomerular immunoglobulins…
  • 2015 American Transplant Congress

    Tolerance to Graft A-Antigens Following ABO-Incompatible Heart Transplantation (HTx) in a Blood Group A-Transgenic Mouse Model

    B. Motyka,1 K. Labonte,1 F. Rahman,1 J. Pearcey,1 K. Tao,1 M. Mengel,1 B. Sis,1 P. Cowan,2 L. West.1

    1Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada; 2Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia.

    Purpose: ABOi HTx can be performed safely in infants when ABO antibody (Ab) levels are low or absent. Following ABOi HTx, immune tolerance develops to…
  • 2015 American Transplant Congress

    Outcomes Following Kidney Transplant With Low Level Positive Flow Cytometric Crossmatch

    C. Schinstock, F. Cosio, M. Gandhi, L. Cornell, M. Stegall.

    Mayo Clinic, Rochester, MN.

    Introduction: Highly-sensitized kidney transplant (KTx) candidates have difficulty finding a negative crossmatch donor. KTx with low level positive crossmatch might be the next best option.…
  • 2015 American Transplant Congress

    Novel Flow Cytometry Method for Detecting Complement-Fixing Blood Group IgG Antibody in ABO-Incompatible Renal Transplantation

    T. Ishizuka,1 M. Yasuo,1 Y. Ishida,1 H. Miura,1 K. Iwadoh,2 T. Murakami,2 K. Kitajima,2 I. Nakajima,2 S. Fuchinoue.2

    1Transplant Immunology, Tokyo Women's Medical University, Shinjuku ward, Tokyo, Japan; 2Surgery III, Tokyo Women's Medical University, Shinjuku ward, Tokyo, Japan.

    【Background】We experienced a hyperacute rejection (HAR) in ABO-incompatible renal transplantation (ABO-I RTx) on POD 0. We hypothesized that complement-fixing IgG anti-A/B blood group antibody (anti-A/B…
  • 2015 American Transplant Congress

    T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques

    C. Burghuber,1,2 J. Kwun,1 E. Page,1 F. Leopardi,3 A. Gibby,1 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…
  • 2015 American Transplant Congress

    B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Response After Transplantation

    J. Marino, P. Crosby Bertorini, J. Paster, A. Trowell, K. Briggs, L. Maxwell, G. Benichou.

    Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA.

    Pre-transplant B cell depletion in NHP with Rituximab (IgG1 anti-CD20 mAb) combined with cyclosporin A has been shown to promote the survival of islets allografts.…
  • 2015 American Transplant Congress

    Immune Response to Kidney and Pancreas Self-Antigens Are Associated With Antibody Mediated Rejection in Simultaneous Kidney Pancreas Transplants

    M. Gunasekaran,1 A. Siddiq,2 S. Shenoy,1 J. Wellen,1 T. Mohanakumar.1

    1Surgery, Washington Univ Sch of Med, St. Louis, MO; 2Medicine, Washington Univ Sch of Med, St. Louis, MO.

    Background: Simultaneous kidney-pancreas transplantation (SKP Tx) is performed as treatment option for type-1 diabetes with end stage kidney diseases. Though allograft survival was improved with…
  • 2015 American Transplant Congress

    Immune-Mediated Injury in Kidney Transplant Recipients Treated With Alemtuzumab Induction and a Steroid Avoidance Protocol

    R. Sapir-Pichhadze, T. Mahbub, C. Saw, D. Baran.

    McGill University Health Centre, Montreal, Canada.

    Study purpose: We evaluated short-term clinical and immunological outcomes of kidney transplant recipients who received alemtuzumab induction and a steroid-avoidance protocol.Methods: This is a retrospective…
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