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Articles tagged "Antibodies"

  • 2016 American Transplant Congress

    Antibody-Mediated Rejection in Pancreas Transplantation.

    O. Serrano,1 D. Vock,2 E. Finger,1 R. Kandaswamy,1 D. Sutherland,1 T. Dunn.1

    1Surgery, Univ. of Minnesota, Minneapolis, MN; 2Biostatistics, University of Minnesota, Minneapolis, MN.

    PURPOSE: The diagnostic criteria for antibody-mediated rejection (AMR) in pancreas transplantation (PTx) is evolving. The incidence and long-term effect of AMR have not been well-described.…
  • 2015 American Transplant Congress

    Variables Related to the Development of Donor Specific Antibodies (DSA) Post-Kidney Transplant (KTx): Implications for Late Graft Histology and Survival

    F. Cosio,1 C. Schinstock,1 M. Stegall.2

    1Medicine, Mayo Clinic, Rochester, MN; 2Surgery, Mayo Clinic, Rochester, MN.

    Introduction. The incidence of de novo DSA increases post-KTx. DSA is associated to reduced graft survival likely due to chronic antibody mediated rejection (cAMR). However,…
  • 2015 American Transplant Congress

    BAFF Binding to T Cell-Expressed BAFF-R Promotes Follicular Helper T Cell Proliferation and GC B Cell Responses

    M. Chen,1 Q. Li,1 W. Stohl,2 S. Zheng,2 X. He,1 Z. Guo.1

    1Organ Transplant Center, 1st affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; 2Division of Rheumatology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA.

    Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF) in promoting germinal center (GC) responses in mouse…
  • 2015 American Transplant Congress

    Serum Creatinine Is Most Predictive of Graft Loss in Late Antibody Mediated Rejection

    G. Agarwal, D. Diskin, R. Reed, J. Locke, V. Kumar.

    Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.

    Development of acute antibody mediated rejection (AMR) is associated with graft loss and can occur both early (< 3 months) and late (> 3 months)…
  • 2015 American Transplant Congress

    Interstitial Fibrosis Is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy

    D. Toki,1 H. Ishida,1 M. Okumi,1 T. Shimizu,1 H. Shirakawa,1 M. Inui,1 K. Omoto,1 K. Unagami,1 T. Kanzawa,1 K. Honda,2 J. Koike,3 K. Tanabe.1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Pathology, Tokyo Women's Medical University, Tokyo, Japan; 3Pathology, Tama Hospital, Kanagawa, Japan.

    PURPOSE: Transplant glomerulopathy (TGP) represents chronic antibody-mediated injury in the glomerular capillaries after renal transplantation, and is the main cause of graft failure. TGP is…
  • 2015 American Transplant Congress

    Impact of Serial Change of Donor Specific Antibodies On the Graft Outcomes After Liver Transplantation

    D. Joo,1,2 J. Lee,3 J. Lee,1,2 J. Lee,1,2 S. Kim,4 D. Han,1,2 M. Ju,1,2 J. Choi,1,2 S. Kim,1,2 M. Kim.1,2

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea; 4Department of Surgery, Wonju Yonsei University College of Medicine, Wonju, Korea.

    Introduction: This study aimed to investigate the acute rejection rate and graft function after liver transplantation according to pre-transplantation donor specific antibody (DSA) status and…
  • 2015 American Transplant Congress

    Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function

    A. Gilbert,1 E. Hall,1 O. Timofeeva,2 M. Awwad,2 M. Grafals,1 P. Weems,1 D. Li,2 S. Rosen-Bronson,2 J. Moore,1 B. Javaid,1 M. Cooper.1

    1Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; 2Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.

    Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
  • 2015 American Transplant Congress

    Outcomes of Kidney Transplantation of ABO- and Crossmatch-Incompatible Recipient-Donor Pairs Entered in Kidney Paired Donation Program

    D. Dadhania, M. Charlton, M. Aull, R. Friedlander, T. Muthukumar, J. Lee, M. Goris, D. Serur, S. Kapur, V. Sharma.

    Transplantation Medicine, Weill Cornell Medical Center, New York, NY.

    Kidney Paired Donation (KPD) enables ABO-incompatible (ABOI) and crossmatch-incompatible (XMI) patients to undergo transplantation using a 'more compatible' donor. Identification of factors that predict early…
  • 2015 American Transplant Congress

    Isotype Switching of Antibodies to Vimentin Following Transplantation Is Associated With Development of Transplant Glomerulopathy Following Renal Transplantation

    M. Gunasekaran,1 T. Maw,3 R. Santos,3 J. Wellen,1 S. Shenoy,1 T. Mohanakumar.1,2

    1Surgery, Washington Univ Sch of Med, St. Louis, MO; 2Pathology & Immunology, Washington Univ Sch of Med, St. Louis, MO; 3Medicine, Washington Univ Sch of Med, St. Louis, MO.

    Background: Immune responses to tissue restricted self antigens have been proposed to play a role in transplant glomerulopathy (TG). The goal of this study is…
  • 2015 American Transplant Congress

    ABO Incompatible Simultaneous Liver-Kidney Transplant With Positive Crossmatch. A Case Report

    T. Heffron,1 C. Kulig,2 P. Gauthier,2 B. Bista,2 S. Dionne,3 T. Pillen,1 M. Asolati.1

    1Surgery, Porter Adventist Hospital, Denver, CO; 2Medicine, Porter Adventist Hospital, Denver, CO; 3LABS, Inc., Centennial, CO.

    INTRODUCTION: Donor Specific (DS) antibodies and ABO incompatibility remain major immunological barriers in organ transplantation. Clinical evidence suggest the liver can protect a kidney from…
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