Articles tagged "Antibodies"

2016 American Transplant Congress
Dynamic Detection of Anti-HLA Antibodies Can Predict aGVHD and OS in HLA-12/12 Matched Unrelated-Donor Allo-HSCT for Hematological Malignancies.
J. He,¹ Z. Pan,¹ X. Yuan,¹ Y. Li,¹ X. Wu,² W. Zhu,² X. Bao,¹ Q. Zhao.²
¹Department of HLA Laboratory, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; ²Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
The NMDP and CIBMTR provided guidelines for the use of anti-HLA antibodies in unrelated-donors hematopoietic stem cell transplantation (HSCT). However, a deeper understanding of other…
2016 American Transplant Congress
Elevated De Novo Donor Specific Antibody After Alemtuzumab Induction in Renal Transplant Recipients.
K. Fabbri, J. Descourouez, M. Jorgenson, R. Redfield.
University of Wisconsin, Madison.
Background: The average annual incidence of de novo donor specific antibody (DSA) has been reported as 3-4% after the first year post-transplant. Recent data suggests…
2016 American Transplant Congress
Development and Validation of a Molecular Microscope Diagnostic System (MMDx) for Heart Transplant Biopsies.
P. Halloran,¹ D. Kim,¹ A. Loupy,² J.-P. Duong Van-Huyen,² P. Bruneval,³ L. Potena,⁴ O. Leone,⁴ J. Reeve.¹
¹University of Alberta, Edmonton, Canada; ²Necker Hospital, Paris, France; ³Hopitaux de Paris, Paris, France; ⁴Bologna University, Bologna, Italy.
The diagnosis of heart transplant rejection by histology in endomyocardial biopsies (EMB) is challenging. A molecular system (MMDx) has been developed to assess both T…
2016 American Transplant Congress
Angiotensin II Type-1 Receptor Antibodies in Renal Transplant Recipients Associated with Ventricular and Endothelial Dysfunction: Preliminary Results.
L. Figuerola-Chaparro,¹ F. Davila-Radilla,¹ E. Cuevas,² L. Castillo-Martínez,¹ A. Orea-Tejeda,¹ J. Arreola-Guerra,² J. Alberu.²
¹Cardiology, Inst Nal Ciencias Medicas y Nutricion SZ, Mexico City, Mexico; ²Transplantation, Inst Nal Ciencias Medicas y Nutricion SZ, Mexico City, Mexico.
Previous studies demonstrated the significance of angiotensin II type-1 receptor antibodies (AT1Rabs) in processes including hypertension, cardiac hypertrophy and renal fibrosis; information regarding ventricular and…
2016 American Transplant Congress
Long-Term Efficacy and Safety of Everolimus Based Immunosuppression on De Novo Kidney Transplantation with 7 Years Follow-Up.
Y. Watarai, M. Okada, K. Futamura, T. Nagai, T. Yamamoto, M. Tsujita, T. Hiramitsu, N. Goto, S. Narumi, T. Kobayashi.
Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan; Kidney Transplant Surgery, Aichi Medical University, Nagoya, Aichi, Japan.
Purpose: Long-term efficacy and safety of everolimus (EVR) based immunosuppression for de novo kidney transplant recipient who were involved in A1202 study from our institute…
2016 American Transplant Congress
Posttransplant AT1Rabs Precede De Novo HLA-DSA Development.
J. Arreola-Guerra,³ E. Cuevas,¹ E. Hernandez-Mendez,¹ M. Vilatoba,¹ A. Contreras,¹ J. Ramirez,¹ D. de Rongs,¹ J. Granados,¹ L. Morales-Buenrostro,² J. Alberu.¹
¹Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; ²Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; ³Tranplantation, Instituto de Servicios de Salud del Estado de Aguascalientes, Aguascalientes, Mexico.
Angiotensin II type 1 receptor antibodies (AT1Rabs) have been associated with acute allograft rejection and graft loss. The possible implication of the generation of de…
2016 American Transplant Congress
BK Nephropathy, but Not Isolated BK Viremia Associated with De Novo DSA Despite Similar Immunosuppression Reduction.
W. Cheungpasitporn,¹ D. Mitema,¹ H. Amer,¹ F. Cosio,¹ M. Stegall,² C. Schinstock.¹
¹Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Transplantation Surgery, Mayo Clinic, Rochester, MN.
Introduction: Reduced immunosuppression is associated with de novo DSA (dn DSA). Although immunosuppression is often reduced in patients with polyomavirus (BK), the incidence of dn…
2016 American Transplant Congress
Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Dept. of Medicine, University of Alberta, Edmonton, AB, Canada; ²Dept. of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: CD16α mediates NK cell responses to donor-specific IgG antibodies (DSA), and shares mechanisms with effector T cell receptor (TCR) stimulation. Whether CD16α-inducible transcripts are…
2016 American Transplant Congress
Everolimus and Low Dose Cyclosporine Immunosuppressive Regimen and Development of Anti HLA Donor Specific Antibodies.
E. Minetti,¹ L. Di Maria,¹ L. Caroti,¹ E. Buti,² P. Carta.¹
¹Nephrology unit, Careggi University Hospital, Florence, Italy; ²Nephrology Unit, Mayer Univerity Hospital, Florence, Italy.
Few data are available on the rate of de novo anti-HLA donor specific antibodies (DSA) with the use of everolimus in kidney transplant recipients.MaterialsWe selected…
2016 American Transplant Congress
Focal C4d Staining in Biopsies of Kidney Transplant Recipients Is Not Associated with Antibody Mediated Rejection and Does Not Correlate with Graft Survival.
R. Prashar, M. Goggins, L. Yessayan, A. Patel, M. Goggins.
Transplant Institute, Henry Ford Hospital, Detroit, MI.
Introduction: While diffuse C4d positivity in kidney transplant peritubular capillaries(PTC) strongly co-relates with the presence of antibody mediated rejection(AMR),data on the significance of focal C4d…